Data from SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Autor: Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali

Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b86af78b2f4b0ea0bc017ba86b84056
https://doi.org/10.1158/1535-7163.c.6542763

Supplementary Data from SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Autor: Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali

supplemental methods, data and figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3813137435b6e50ede54df16b76c6dfc
https://doi.org/10.1158/1535-7163.22520769.v1

Discovery and Chemical Development of Amcenestrant: An Oral Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer

Autor: Youssef El-Ahmad, Veronique Croq, Christian Wehrey, Maysoun Shomali, Laurent Schio

Publikováno v: ACS Symposium Series ISBN: 9780841297333

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d926dc0916fc9b48c711bcdc18b28b0
https://doi.org/10.1021/bk-2022-1423.ch007

Optimization and Gram-Scale Preparation of S -Trifluoromethyl Sulfoximines and Sulfilimino Iminiums, Powerful Reagents for the Late Stage Introduction of the CF 3 Group

Autor: Youssef El-Ahmad, Laurence Fabien, Luc Bertin, Guillaume Dagousset, Christian Poma, Elsa Anselmi, Bruno Salgues, Victor Certal, Philippe Courtes, Anne-Laure Barthelemy, Emmanuel Magnier

Publikováno v: Organic Process Research and Development
Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.704-712. ⟨10.1021/acs.oprd.9b00403⟩

S-Trifluoromethyl sulfoximines and S-trifluoromethyl sulfilimino iminiums are important reagents for the electrophilic or radical late-stage introduction of the CF3 group. We disclose in this artic...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0b114c3d1037db332e87d0c0a92fed
https://hal.archives-ouvertes.fr/hal-02992781

Abstract P4-02-08: Amcenestrant in combination with CDK4/6 inhibitor palbociclib demonstrates synergistic anti-tumor activity in ER+ endocrine-resistant breast cancer xenograft models

Autor: Maysoun Shomali, Zhuyan Guo, Jane Cheng, Amy Sullivan, Youssef El-Ahmad, Fangxian Sun, Sukhvinder Sidhu, Joon Sang Lee, Hui Cai, Jack Pollard, Laurent Debussche, Chris Soria, Monsif Bouaboula

Publikováno v: Cancer Research. 82:P4-02

Nearly 70% of newly diagnosed cases of breast cancer (BC) are estrogen receptor positive (ER+) where endocrine therapy is a primary treatment. Despite initial efficacy seen with endocrine therapies, approximately 40% of patients develop acquired resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2505d83d780d649e8ce322533ce5307
https://doi.org/10.1158/1538-7445.sabcs21-p4-02-08