Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Youssef Dgachi"'
Autor:
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs
Externí odkaz:
https://doaj.org/article/e3c0e08c463645d08a8cc7dd58a4bda9
Autor:
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Molecules, Vol 21, Iss 5, p 634 (2016)
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe
Externí odkaz:
https://doaj.org/article/275dbed00fe84937878fb5586f6d45ed
Autor:
Jana Janockova, Ondrej Soukup, Daniel Jun, Mourad Chioua, José Marco-Contelles, Ignacio Moraleda, Lhassane Ismaili, Vendula Sepsova, Fakher Chabchoub, Isabel Iriepa, Hélène Martin, Youssef Dgachi, Estefanía Serrano
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In this report we describe the synthesis, biological evaluation and molecular modeling of new tacrine analogues such as QuinoPyranTacrines (QPTs), designed by juxtaposition of 1,4- naphthoquinone and tacrine. From these results we have identified QPT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d7bc42aa7134969baa652e03c10428
https://doi.org/10.1002/slct.201702781
https://doi.org/10.1002/slct.201702781
Autor:
Fatma Aloui, Fakher Chabchoub, Mohamed Bouaziz, Imen Aissa, Youssef Dgachi, Youssef Gargouri, Nadia Kharrat
Publikováno v:
Bioorganic chemistry. 75
In this study, the enzymatic synthesis of phenylacetoyl glycerol ester was carried out as a response to the increasing consumer demand for natural compounds. 1,3-dihydroxyphenylacetoyl -sn- Glycerol (1,3-di-HPA-Gly), labeled as “natural” compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfc3b778319729ad37bea534f1c1842
https://pubmed.ncbi.nlm.nih.gov/29096095
https://pubmed.ncbi.nlm.nih.gov/29096095
Autor:
Isabel Iriepa, Youssef Dgachi, Fakher Chabchoub, Lhassane Ismaili, José Marco-Contelles, Mourad Chioua, Alexandre Bonet, Hélène Martin, Ignacio Moraleda
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Aim: Due to the complex nature of Alzheimer's disease, there is a renewed search for multitarget directed drugs. Results: This paper describes the synthesis and in vitro biological evaluation of six racemic 13-aryl-2,3,4,13-tetrahydro-1H,12H-benzo[6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdad678fa89f0e96cb9508bbfd94901
http://hdl.handle.net/10261/153671
http://hdl.handle.net/10261/153671
Autor:
Lhassane Ismaili, Ondrej Soukup, Fakher Chabchoub, Jana Janockova, Ignacio Moraleda, Hélène Martin, Cristina García-Iriepa, José Marco-Contelles, Isabel Iriepa, Barbara Malawska, Alexandre Bonet, Youssef Dgachi, Lysiane Richert, Dawid Panek, Olga Sokolov, Justyna Godyń, Vincent Luzet
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f074fac087af99ac630e3b71eb837d
https://ruj.uj.edu.pl/xmlui/handle/item/118897
https://ruj.uj.edu.pl/xmlui/handle/item/118897
Autor:
Alexandre Bonet, Damijan Knez, Oscar M. Bautista-Aguilera, Fakher Chabchoub, Barbara Malawska, Jana Janockova, Hélène Martin, Stanislav Gobec, Ondrej Soukup, Mohamed Benchekroun, Mourad Chioua, Youssef Dgachi, Justyna Godyń, Lhassane Ismaili, José Marco-Contelles
Publikováno v:
Molecules; Volume 21; Issue 5; Pages: 634
Molecules, vol. 21, no. 5, 634, 2016.
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules, Vol 21, Iss 5, p 634 (2016)
Molecules
Molecules, vol. 21, no. 5, 634, 2016.
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules, Vol 21, Iss 5, p 634 (2016)
Molecules
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb8ba2adcd2291909f2de44af8d158c
Autor:
Fakher Chabchoub, Oscar M. Bautista-Aguilera, Sarah Wehle, Damijan Knez, José Marco-Contelles, Michael Decker, Natalia Szałaj, Mohamed Benchekroun, Alexandre Bonnet, Mourad Chioua, Hélène Martin, Vincent Luzet, Youssef Dgachi, Stanislav Gobec, Barbara Malawska, Lhassane Ismaili
Given the complex nature of Alzheimer's disease (AD), compounds that are able to simultaneously address two or more AD-associated targets show greater promise for development into drugs for AD therapy. Herein we report an efficient two-step synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb535b9d098c9a08ae1d321ada7d0e0
https://ruj.uj.edu.pl/xmlui/handle/item/108382
https://ruj.uj.edu.pl/xmlui/handle/item/108382