Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Youssef A. Elhaji"'
Publikováno v:
Essays in Biochemistry. 40:121-136
The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e033aacf9dc506cd5ee444e593826291
https://doi.org/10.1042/bse0400121
https://doi.org/10.1042/bse0400121
Autor:
Jian Wu, Shereen A. Ghali, Youssef A. Elhaji, Rose Lumbroso, Leonard Pinsky, Bruce Gottlieb, Mark Trifiro, Lenore K. Beitel
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:2185-2193
Five mutations in the ligand-binding domain (LBD) of the human androgen receptor (hAR) found in patients with varying degrees of androgen insensitivity syndrome (AIS) were investigated for their effects on receptor dynamics. These were Arg(871)Gly (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007092a8f4aa9dd276e8345af373ba81
https://doi.org/10.1210/jc.2002-021324
https://doi.org/10.1210/jc.2002-021324
Autor:
Ileana Stoica, Youssef A. Elhaji, Rose Lumbroso, Mark Trifiro, Enrico O. Purisima, Sheldon Dennis, Lenore K. Beitel
Publikováno v:
Human molecular genetics. 15(6)
Structural studies of the ligand-binding domain (LBD) of several steroid receptors have revealed that thedynamic properties of the C-terminal helix 12 (H12) are the major determinant of the activation mode ofthese receptors. H12 exhibits high mobilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cf0c421ab491b7467b3f252c17f36a
https://pubmed.ncbi.nlm.nih.gov/16449235
https://pubmed.ncbi.nlm.nih.gov/16449235
Autor:
Rose Lumbroso, L Pinsky, Youssef A. Elhaji, SS Wing, Mark Trifiro, Bruce Gottlieb, Lenore K. Beitel, Valerie Panet-Raymond
Publikováno v:
Journal of molecular endocrinology. 29(1)
The androgen receptor (AR) N-terminal domain plays a critical role in androgen-responsive gene regulation. A novel AR N-terminal-interacting protein (ARNIP) was isolated using the yeast two-hybrid system and its interaction with amino acids 11-172 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9143ae906ed9f491a2569dd2546324cf
https://pubmed.ncbi.nlm.nih.gov/12200228
https://pubmed.ncbi.nlm.nih.gov/12200228
Autor:
Rose Lumbroso, Lenore K. Beitel, Mark Trifiro, Bruce Gottlieb, Leonard Pinsky, William D. Foulkes, Youssef A. Elhaji
Publikováno v:
Breast cancer research and treatment. 70(2)
Previous investigations into the relationship of CAG-repeat lengths in the androgen receptor (AR) gene to female breast cancer (BC) have yielded somewhat confusing results. Decreased AR transactivational activity lowers androgen:estrogen balance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9303d2f06686f517195d86a02ac9a6b
https://pubmed.ncbi.nlm.nih.gov/11768600
https://pubmed.ncbi.nlm.nih.gov/11768600
Autor:
Mark Trifiro, Leonard Pinsky, Bruce Gottlieb, Youssef A. Elhaji, Lenore K. Beitel, Annie M.J. Beauchemin
Publikováno v:
Brain research bulletin. 56(3-4)
Spinobulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by the expansion of the polyglutamine (polyGln) tract in the human androgen receptor (hAR). One mechanism by which polyGln-expanded proteins are believed to cause neuronotoxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710b6a574d4dfd9e67ae4a0b706490a9
https://pubmed.ncbi.nlm.nih.gov/11719263
https://pubmed.ncbi.nlm.nih.gov/11719263