Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Youssef, Sidhom"'
Autor:
Sifat Sharmin, Francesca Bovis, Charles Malpas, Dana Horakova, Eva Kubala Havrdova, Guillermo Izquierdo, Sara Eichau, Maria Trojano, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Francois Grand'Maison, Pierre Grammond, Patrizia Sola, Diana Ferraro, Murat Terzi, Oliver Gerlach, Raed Alroughani, Cavit Boz, Vahid Shaygannejad, Vincent van Pesch, Elisabetta Cartechini, Ludwig Kappos, Jeannette Lechner‐Scott, Roberto Bergamaschi, Recai Turkoglu, Claudio Solaro, Gerardo Iuliano, Franco Granella, Bart Van Wijmeersch, Daniele Spitaleri, Mark Slee, Pamela McCombe, Julie Prevost, Radek Ampapa, Serkan Ozakbas, Jose Luis Sanchez‐Menoyo, Aysun Soysal, Steve Vucic, Thor Petersen, Koen de Gans, Ernest Butler, Suzanne Hodgkinson, Youssef Sidhom, Riadh Gouider, Edgardo Cristiano, Tamara Castillo‐Triviño, Maria Laura Saladino, Michael Barnett, Fraser Moore, Csilla Rozsa, Bassem Yamout, Olga Skibina, Anneke van der Walt, Katherine Buzzard, Orla Gray, Stella Hughes, Angel Perez Sempere, Bhim Singhal, Yara Fragoso, Cameron Shaw, Allan Kermode, Bruce Taylor, Magdolna Simo, Neil Shuey, Talal Al‐Harbi, Richard Macdonell, Jose Andres Dominguez, Tunde Csepany, Carmen Adella Sirbu, Maria Pia Sormani, Helmut Butzkueven, Tomas Kalincik
Publikováno v:
Sharmin, S, Bovis, F, Malpas, C, Horakova, D, Havrdova, EK, Izquierdo, G, Eichau, S, Trojano, M, Prat, A, Girard, M, Duquette, P, Onofrj, M, Lugaresi, A, Grand'Maison, F, Grammond, P, Sola, P, Ferraro, D, Terzi, M, Gerlach, O, Alroughani, R, Boz, C, Shaygannejad, V, van Pesch, V, Cartechini, E, Kappos, L, Lechner-Scott, J, Bergamaschi, R, Turkoglu, R, Solaro, C, Iuliano, G, Granella, F, Van Wijmeersch, B, Spitaleri, D, Slee, M, McCombe, P, Prevost, J, Ampapa, R, Ozakbas, S, Sanchez-Menoyo, JL, Soysal, A, Vucic, S, Petersen, T, de Gans, K, Butler, E, Hodgkinson, S, Sidhom, Y, Gouider, R, Cristiano, E, Castillo-Triviño, T, Saladino, ML, Barnett, M, Moore, F, Rozsa, C, Yamout, B, Skibina, O, van der Walt, A, Buzzard, K, Gray, O, Hughes, S, Sempere, A P, Singhal, B, Fragoso, Y, Shaw, C, Kermode, A, Taylor, B, Simo, M, Shuey, N, Al-Harbi, T, Macdonell, R, Dominguez, J A, Csepany, T, Sirbu, CA, Sormani, M P, Butzkueven, H & Kalincik, T 2022, ' Confirmed disability progression as a marker of permanent disability in multiple sclerosis ', European Journal of Neurology, vol. 29, no. 8, pp. 2321-2334 . https://doi.org/10.1111/ene.15406
European journal of neurology, Vol. 154, no.06, p. 1-14 (2022)
EUROPEAN JOURNAL OF NEUROLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
European journal of neurology, Vol. 154, no.06, p. 1-14 (2022)
EUROPEAN JOURNAL OF NEUROLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
Background and purpose The prevention of disability over the long term is the main treatment goal in multiple sclerosis (MS); however, randomized clinical trials evaluate only short-term treatment effects on disability. This study aimed to define cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be5fc1b9a1be3af0614b0839ee2213c
https://pure.au.dk/portal/da/publications/confirmed-disability-progression-as-a-marker-of-permanent-disability-in-multiple-sclerosis(109a4ca9-a31c-44b7-8b0d-3013013e0013).html
https://pure.au.dk/portal/da/publications/confirmed-disability-progression-as-a-marker-of-permanent-disability-in-multiple-sclerosis(109a4ca9-a31c-44b7-8b0d-3013013e0013).html
Publikováno v:
Bulletin de l'Académie Nationale de Médecine. 204:421-427
Resume La sclerose en plaques est une maladie inflammatoire chronique du systeme nerveux central d’etiologie auto-immune. Son phenotype et son evolution peuvent differer d’un patient a l’autre. L’epidemiologie et la presentation de la scleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8489149a048c9868a60750b5cf5222a7
https://doi.org/10.1016/j.banm.2019.09.003
https://doi.org/10.1016/j.banm.2019.09.003
Autor:
Youssef Sidhom, Mouna Ben Djebara, Yosr Hizem, Istabrak Abdelkefi, Imen Kacem, Amina Gargouri, Riadh Gouider
Publikováno v:
Behavioural Neurology, Vol 2014 (2014)
Background. The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological
Externí odkaz:
https://doaj.org/article/189c66cd99714f97bf3c709fcf16319b
Autor:
Tomas Kalincik, Marc Girard, Corinne Pottier, Murat Terzi, Jean Pelletier, Oliver Gerlach, Julie Prevost, Dana Horakova, Francois Grand'Maison, Raed Alroughani, Guillermo Izquierdo, Francesco Patti, Federico Frascoli, Maria Trojano, Franco Granella, Pamela A. McCombe, Charles B Malpas, Recai Turkoglu, Aurélie Ruet, Jonathan Ciron, Tünde Csépány, Nicolas Maubeuge, Helmut Butzkueven, Pierre Clavelou, Tamara Castillo Trivino, Marco Onofrj, Jean Philippe Camdessanche, Pierre Labauge, Vincent Van Pesch, Pierre Grammond, Abir Wahab, Roberto Bergamaschi, Aysun Soysal, Diana Ferraro, Bertrand Bourre, Olivier Gout, Jeannette Lechner-Scott, Sara Eichau, Emmanuelle Leray, Alexis Montcuquet, Pierre Duquette, Olivier Casez, Youssef Sidhom, Patrizia Sola, Bart Van Wijmeersch, Izanne Roos, Gilles Edan, Serkan Ozakbas, David Laplaud, Sandra Vukusic, Abdullatif Al Khedr, Céline Labeyrie, Philippe Cabre, Eric Thouvenot, Céline Louapre, Romain Casey, Alessandra Lugaresi, Riadh Gouider, Alasdair Coles, Eric Berger, Ivania Patry, Gerardo Iuliano, Elisabetta Cartechini, Cavit Boz, Karolina Hankiewicz, Eva Havrdova, Eduardo Aguera-Morales, J William L Brown, Jérôme De Seze, Bruno Stankoff, Olivier Heinzlef, Gilles Defer, Alexandre Prat, Chantal Nifle, Maria José Sá, Marc Debouverie, Daniele Spitaleri, Aude Maurousset, Thibault Moreau, Christine Lebrun-Frenay, Hélène Zéphir
Publikováno v:
Multiple Sclerosis Journal
Multiple Sclerosis Journal, SAGE Publications, 2021, ⟨10.1177/1352458520981300⟩
Multiple sclerosis journal, Vol. 27, no. 12, p. 1838-1851 (2021)
Multiple Sclerosis Journal, SAGE Publications, 2021, 27 (12), pp.1838-1851. ⟨10.1177/1352458520981300⟩
Neurology
Neurology, American Academy of Neurology, 2020, 94 (15)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Publons
Web of Science
HAL
Multiple Sclerosis Journal, 2021, 27 (12), pp.1838-1851. ⟨10.1177/1352458520981300⟩
Neurology, 2020, 94 (15)
Multiple Sclerosis Journal, SAGE Publications, 2021, ⟨10.1177/1352458520981300⟩
Multiple sclerosis journal, Vol. 27, no. 12, p. 1838-1851 (2021)
Multiple Sclerosis Journal, SAGE Publications, 2021, 27 (12), pp.1838-1851. ⟨10.1177/1352458520981300⟩
Neurology
Neurology, American Academy of Neurology, 2020, 94 (15)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Publons
Web of Science
HAL
Multiple Sclerosis Journal, 2021, 27 (12), pp.1838-1851. ⟨10.1177/1352458520981300⟩
Neurology, 2020, 94 (15)
International audience; Objective: To explore the associations of patient and disease characteristics with the duration of therapeutic lag for relapses and disability progression.Background: Therapeutic lag represents the delay from initiation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd275779a0a2c8bfba24596975ed900
https://hdl.handle.net/11380/1251074
https://hdl.handle.net/11380/1251074
Autor:
Bassem Yamout, Alessandra Lugaresi, Pierre Duquette, Anneke van der Walt, Eva Havrdova, Jose Luis Sanchez-Menoyo, Alexandre Prat, Raymond Hupperts, Vincent Van Pesch, Cristina Ramo-Tello, Jeannette Lechner-Scott, Francois Grand’ Maison, Guillermo Izquierdo, Steve Vucic, Roberto Bergamaschi, Cavit Boz, Ayse Altintas, Vahid Shaygannejad, Aysun Soysal, Youssef Sidhom, Tomas Kalincik, Charles B Malpas, Marc Girard, Serkan Ozakbas, Julie Prevost, Raed Alroughani, Catherine Larochelle, Michael Barnett, Daniele Spitaleri, Pamela A. McCombe, Thor Petersen, Mark Slee, Helmut Butzkueven, Maria Trojano, Franco Granella, Minh Le, Yara Dadalti Fragoso, Pierre Grammond, Radek Ampapa, Riadh Gouider, Gerardo Iuliano, Recai Turkoglu, Murat Terzi, Eugenio Pucci, Sifat Sharmin, Diana Ferraro, Sara Eichau, Patrizia Sola, Dana Horakova
Publikováno v:
Multiple Sclerosis Journal, Vol. 27, no.5, p. 755-766 (2021)
MULTIPLE SCLEROSIS JOURNAL
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Le, M, Malpas, C, Sharmin, S, Horáková, D, Havrdova, E, Trojano, M, Izquierdo, G, Eichau, S, Ozakbas, S, Lugaresi, A, Prat, A, Girard, M, Duquette, P, Larochelle, C, Alroughani, R, Bergamaschi, R, Sola, P, Ferraro, D, Grammond, P, Grand’ Maison, F, Terzi, M, Boz, C, Hupperts, R, Butzkueven, H, Pucci, E, Granella, F, Van Pesch, V, Soysal, A, Yamout, B I, Lechner-Scott, J, Spitaleri, D L A, Ampapa, R, Turkoglu, R, Iuliano, G, Ramo-Tello, C, Sanchez-Menoyo, J L, Sidhom, Y, Gouider, R, Shaygannejad, V, Prevost, J, Altintas, A, Fragoso, Y D, McCombe, P A, Petersen, T, Slee, M, Barnett, M H, Vucic, S, Van Der Walt, A & Kalincik, T 2021, ' Disability outcomes of early cerebellar and brainstem symptoms in multiple sclerosis ', Multiple Sclerosis Journal, vol. 27, no. 5, pp. 755-766 . https://doi.org/10.1177/1352458520926955
MULTIPLE SCLEROSIS JOURNAL
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Le, M, Malpas, C, Sharmin, S, Horáková, D, Havrdova, E, Trojano, M, Izquierdo, G, Eichau, S, Ozakbas, S, Lugaresi, A, Prat, A, Girard, M, Duquette, P, Larochelle, C, Alroughani, R, Bergamaschi, R, Sola, P, Ferraro, D, Grammond, P, Grand’ Maison, F, Terzi, M, Boz, C, Hupperts, R, Butzkueven, H, Pucci, E, Granella, F, Van Pesch, V, Soysal, A, Yamout, B I, Lechner-Scott, J, Spitaleri, D L A, Ampapa, R, Turkoglu, R, Iuliano, G, Ramo-Tello, C, Sanchez-Menoyo, J L, Sidhom, Y, Gouider, R, Shaygannejad, V, Prevost, J, Altintas, A, Fragoso, Y D, McCombe, P A, Petersen, T, Slee, M, Barnett, M H, Vucic, S, Van Der Walt, A & Kalincik, T 2021, ' Disability outcomes of early cerebellar and brainstem symptoms in multiple sclerosis ', Multiple Sclerosis Journal, vol. 27, no. 5, pp. 755-766 . https://doi.org/10.1177/1352458520926955
Background:Cerebellar and brainstem symptoms are common in early stages of multiple sclerosis (MS) yet their prognostic values remain unclear.Objective:The aim of this study was to investigate long-term disability outcomes in patients with early cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174c4b7aceaebfb58e65ab0b9ffd8cdf
https://pubmed.ncbi.nlm.nih.gov/32538713
https://pubmed.ncbi.nlm.nih.gov/32538713
Autor:
Tomas Kalincik, Marc Girard, Guillermo Izquierdo, Cristina Ramo-Tello, Francois Grand'Maison, Ali Manouchehrinia, Youssef Sidhom, Charles B Malpas, Alexandre Prat, Maria Trojano, Franco Granella, Pamela A. McCombe, Rana Karabudak, Murat Terzi, Eugenio Pucci, Raymond Hupperts, Vincent Van Pesch, Pierre Grammond, Sifat Sharmin, Richard A L Macdonell, Ayse Altintas, Riadh Gouider, Recai Turkoglu, Diana Ferraro, Alessandra Lugaresi, Pierre Duquette, Helmut Butzkueven, Serkan Ozakbas, Sara Eichau, Izanne Roos, Daniele Spitaleri, Yara Dadalti Fragoso, Mark Slee, Roberto Bergamaschi, Jan Hillert, Edgardo Cristiano, Thor Petersen, Eva Havrdova, Javier Olascoaga, Cavit Boz, Patrizia Sola, Freek Verheul, Aysun Soysal, Tomas Olsson, Dana Horakova
Publikováno v:
Brain
Malpas, C B, Manouchehrinia, A, Sharmin, S, Roos, I, Horakova, D, Havrdova, E K, Trojano, M, Izquierdo, G, Eichau, S, Bergamaschi, R, Sola, P, Ferraro, D, Lugaresi, A, Prat, A, Girard, M, Duquette, P, Grammond, P, Grand'Maison, F, Ozakbas, S, Van Pesch, V, Granella, F, Hupperts, R, Pucci, E, Boz, C, Sidhom, Y, Gouider, R, Spitaleri, D, Soysal, A, Petersen, T, Verheul, F, Karabudak, R, Turkoglu, R, Ramo-Tello, C, Terzi, M, Cristiano, E, Slee, M, McCombe, P, Macdonell, R, Fragoso, Y, Olascoaga, J, Altintas, A, Olsson, T, Butzkueven, H, Hillert, J & Kalincik, T 2020, ' Early clinical markers of aggressive multiple sclerosis ', Brain : a journal of neurology, vol. 143, no. 5, pp. 1400-1413 . https://doi.org/10.1093/brain/awaa081
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Brain, Vol. 143, no. 5, p. 1400-1413 (2020)
Malpas, C B, Manouchehrinia, A, Sharmin, S, Roos, I, Horakova, D, Havrdova, E K, Trojano, M, Izquierdo, G, Eichau, S, Bergamaschi, R, Sola, P, Ferraro, D, Lugaresi, A, Prat, A, Girard, M, Duquette, P, Grammond, P, Grand'Maison, F, Ozakbas, S, Van Pesch, V, Granella, F, Hupperts, R, Pucci, E, Boz, C, Sidhom, Y, Gouider, R, Spitaleri, D, Soysal, A, Petersen, T, Verheul, F, Karabudak, R, Turkoglu, R, Ramo-Tello, C, Terzi, M, Cristiano, E, Slee, M, McCombe, P, Macdonell, R, Fragoso, Y, Olascoaga, J, Altintas, A, Olsson, T, Butzkueven, H, Hillert, J & Kalincik, T 2020, ' Early clinical markers of aggressive multiple sclerosis ', Brain : a journal of neurology, vol. 143, no. 5, pp. 1400-1413 . https://doi.org/10.1093/brain/awaa081
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Brain, Vol. 143, no. 5, p. 1400-1413 (2020)
Patients with the 'aggressive' form of multiple sclerosis accrue disability at an accelerated rate, typically reaching Expanded Disability Status Score (EDSS) ≥ 6 within 10 years of symptom onset. Several clinicodemographic factors have been associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b803c68f504d99dc80bdbe0d0af6fa
https://hdl.handle.net/20.500.12712/2209
https://hdl.handle.net/20.500.12712/2209
Autor:
Michael Barnett, Bhim Singhal, Maria Trojano, Franco Granella, Neil Shuey, Guillermo Izquierdo, Dana Horakova, Helmut Butzkueven, Talal Al-Harbi, Maria Laura Saladino, Cameron Shaw, Adam Fambiatos, Bart Van Wijmeersch, Serkan Ozakbas, Tünde Csépány, Freek Verheul, Cavit Boz, Tim Spelman, Pierre Duquette, Jeannette Lechner-Scott, Bassem Yamout, Roberto Bergamaschi, Vincent Van Pesch, Claudio Solaro, Edgardo Cristiano, Patrizia Sola, Vilija Jokubaitis, Jae Kwan Jun, Alessandra Lugaresi, Javier Olascoaga, Aysun Soysal, Thor Petersen, Mark Slee, Raed Alroughani, Francois Grand'Maison, Orla Gray, Tomas Kalincik, Marc Girard, Gerardo Iuliano, Anneke van der Walt, Eva Havrdova, Jose Luis Sanchez-Menoyo, Radek Ampapa, Julie Prevost, Steve Vucic, Pamela A. McCombe, Recai Turkoglu, Yara Dadalti Fragoso, Jordana Hughes, Olga Skibina, Murat Terzi, Eugenio Pucci, Diana Ferraro, Pierre Grammond, Fraser Moore, Ayse Altintas, Suzanne Hodgkinson, Youssef Sidhom, Norma Deri, Alexandre Prat, Raymond Hupperts, Daniele Spitaleri, Bruce V. Taylor
Publikováno v:
Fambiatos, A, Jokubaitis, V, Horakova, D, Kubala Havrdova, E, Trojano, M, Prat, A, Girard, M, Duquette, P, Lugaresi, A, Izquierdo, G, Grand’Maison, F, Grammond, P, Sola, P, Ferraro, D, Alroughani, R, Terzi, M, Hupperts, R, Boz, C, Lechner-Scott, J, Pucci, E, Bergamaschi, R, Van Pesch, V, Ozakbas, S, Granella, F, Turkoglu, R, Iuliano, G, Spitaleri, D, McCombe, P, Solaro, C, Slee, M, Ampapa, R, Soysal, A, Petersen, T, Sanchez-Menoyo, J L, Verheul, F, Prevost, J, Sidhom, Y, Van Wijmeersch, B, Vucic, S, Cristiano, E, Saladino, M L, Deri, N, Barnett, M, Olascoaga, J, Moore, F, Skibina, O, Gray, O, Fragoso, Y, Yamout, B, Shaw, C, Singhal, B, Shuey, N, Hodgkinson, S, Altintas, A, Al-Harbi, T, Csepany, T, Taylor, B, Hughes, J, Jun, J K, van der Walt, A, Spelman, T, Butzkueven, H & Kalincik, T 2020, ' Risk of secondary progressive multiple sclerosis : A longitudinal study ', Multiple Sclerosis Journal, vol. 26, no. 1, pp. 79-90 . https://doi.org/10.1177/1352458519868990
Multiple sclerosis, Vol. 26, no. 1, p. 79-90 (2020)
Multiple sclerosis, Vol. 26, no. 1, p. 79-90 (2020)
Turkoglu, Recai/0000-0001-9724-851X; Ferraro, Diana/0000-0003-4818-3806; McCombe, Pamela/0000-0003-2704-8517; Altintas, Ayse/0000-0002-8524-5087; Jokubaitis, Vilija G./0000-0002-3942-4340; Slee, Mark/0000-0003-4323-2453; Lugaresi, Alessandra/0000-000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cd799ef882d65d54c9d7ef34b33e78
https://avesis.deu.edu.tr/publication/details/fb9b47c1-d816-40b5-86de-96e112b6f8f9/oai
https://avesis.deu.edu.tr/publication/details/fb9b47c1-d816-40b5-86de-96e112b6f8f9/oai
Autor:
Sonia Abdelhak, Mouna Ben Djebara, Rym Kefi, Riadh Gouider, A. Gargouri-Berrechid, Zied Landoulsi, Youssef Sidhom, Imen Kacem
Publikováno v:
Medical Principles and Practice. 27:317-322
Objective: Rare variants in the TREM2 gene have been reported to significantly increase the risk of Alzheimer’s disease in Caucasian populations. Hitherto, this association was not studied in North African populations. In this work, we aimed to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89c92ae49a4d8f49a18089aa79ac23d9
https://doi.org/10.1159/000489779
https://doi.org/10.1159/000489779
Publikováno v:
The Journal of Spinal Cord Medicine. 41:490-495
CONTEXT: Cervical root avulsion secondary to traumatic plexus injury is a rare etiology of superficial siderosis (SS) of the central nervous system (CNS). We describe the case of an isolated progressive compressive myelopathy revealing this complicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163101b4eeb9150adf641b3f3e364082
https://doi.org/10.1080/10790268.2017.1329053
https://doi.org/10.1080/10790268.2017.1329053
Autor:
Ayse Altintas, Freek Verheul, Maria Trojano, Franco Granella, Richard A L Macdonell, Aysun Soysal, Gerardo Iuliano, Roberto Bergamaschi, Pierre Grammond, Daniele Spitaleri, Francois Grand'Maison, Rana Karabudak, Murat Terzi, Ali Manouchehrinia, Eugenio Pucci, Mark Slee, Alessandra Lugaresi, Yara Dadalti Fragoso, Sifat Sharmin, Jan Hillert, Riadh Gouider, Thor Petersen, Vincent Van Pesch, Recai Turkoglu, Diana Ferraro, Cristina Ramo-Tello, Helmut Butzkueven, Alexandre Prat, Sara Eichau, Izanne Roos, Serkan Ozakbas, Raymond Hupperts, Edgardo Cristiano, Tomas Olsson, Guillermo Izquierdo, Youssef Sidhom, Charles B Malpas, Dana Horakova, Eva Havrdova, Pierre Duquette, Cavit Boz, Javier Olascoaga, Pamela A. McCombe, Patrizia Sola, Tomas Kalincik, Marc Girard
Patients with the ‘aggressive’ form of MS accrue disability at an accelerated rate, typically reaching EDSS >= 6 within 10 years of symptom onset. Several clinicodemographic factors have been associated with aggressive MS, but less research has f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df1a8241049d23819887782fd26fbcc
https://doi.org/10.1101/19002063
https://doi.org/10.1101/19002063