Výsledky vyhledávání - "Yousra Hamdane"

N-Amino-imidazol-2-one (Nai) Residues as Tools for Peptide Mimicry: Synthesis, Conformational Analysis and Biomedical Applications

Autor: William D. Lubell, Yousra Hamdane, Julien Poupart

Publikováno v: Synthesis. 54:1518-1526

N-Amino-imidazol-2-one (Nai) residues are tools for studying peptide-backbone and side-chain conformation and function. Recent methods for substituted Nai residue synthesis, conformational analysis by X-ray crystallography and computation, and biomed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbd807653d52c2b8aac25fc968232ecb
https://doi.org/10.1055/s-0040-1719862

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5-Substituted N-Aminoimidazolone Peptide Mimic Synthesis by Organocatalyzed Reactions of Azopeptides and Use in the Analysis of Biologically Active Backbone and Side-Chain Topology

Autor: Yousra Hamdane, Suresh Vutla, Pradeep S. Chauhan, Mukandila Mulumba, William D. Lubell, Huy Ong

Publikováno v: Organic Letters. 23:3491-3495

Fifteen N-aminoimidazolone (Nai) dipeptides having a variety of 5-position side-chain groups were synthesized by regioselective proline-catalyzed reactions of azopeptide and aldehyde components followed by acid-mediated dehydration of an aza-aspartat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1a0752cee062ae1cd7413599b810dd7
https://doi.org/10.1021/acs.orglett.1c00936

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Hydrazine derivative synthesis by trifluoroacetyl hydrazide alkylation

Autor: Charity Deborah Yongo-Luwawa, Yousra Hamdane, Sitan Diarra, Mulamreddy Ramakotaiah, Pradeep S. Chauhan, Anh Minh Thao Nguyen, William D. Lubell, Xiaozheng Wei, Skye Brettell

Publikováno v: Canadian Journal of Chemistry. 98:485-494

N′-Alkyl hydrazides were effectively synthesized by routes featuring installation, alkylation, and removal of a trifluoroacetyl group. A set of amino acid derived hydrazides were acylated using trifluoroacetic anhydride, and the resulting trifluoro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38eb3aebec7fc431ac516514d86ef426
https://doi.org/10.1139/cjc-2020-0052

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Synthesis of enantiomerically enriched 4,5-disubstituted N-aminoimidazol-2-one (Nai) peptide turn mimics

Autor: Julien Poupart, Yousra Hamdane, William D. Lubell

Publikováno v: Canadian Journal of Chemistry. 98:278-284

N-Aminoimidazolone (Nai) peptide mimics were synthesized with minimal epimerization by base-promoted 5-endo-dig cyclization of aza-propargylglycine dipeptide acids and hydrazides followed by olefin migration. 5-Position functionalization using Mannic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cc54ba541e07b3f13d8e35d4940d53d
https://doi.org/10.1139/cjc-2019-0479

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5-Substituted

Autor: Yousra, Hamdane, Pradeep S, Chauhan, Suresh, Vutla, Mukandila, Mulumba, Huy, Ong, William D, Lubell

Publikováno v: Organic letters. 23(9)

Fifteen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c680208169fb275809bf450b318d5247
https://pubmed.ncbi.nlm.nih.gov/33886343

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