Výsledky vyhledávání - "Yousif A. Kariri"

Akademický článek

The role of the ALKBH5 RNA demethylase in invasive breast cancer

Autor: Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan

Publikováno v: Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m

Externí odkaz: https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135

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The prognostic significance of interferon-stimulated gene 15 (ISG15) in invasive breast cancer

Autor: Omar J. Mohammed, Michael S. Toss, Emad A. Rakha, Chitra Joseph, Mansour Alsaleem, Sami Alsaeed, Yousif A Kariri, Andrew R. Green, Abrar I. Aljohani, Sho Shiino

Publikováno v: Breast Cancer Research and Treatment

Background Lymphovascular invasion (LVI) is a prognostic factor in early-stage invasive breast cancer (BC). Through bioinformatics, data analyses of multiple BC cohorts revealed the positive association between interferon-stimulated gene 15 (ISG15) L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec41c2ed0d2a0d30ebffe1ebd4733129
http://europepmc.org/articles/PMC7867506

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Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer

Autor: Yousif A. Kariri, Chitra Joseph, Mansour A. Alsaleem, Khloud A. Elsharawy, Sami Alsaeed, Michael S. Toss, Nigel P. Mongan, Andrew R. Green, Emad A. Rakha

Publikováno v: Cancers; Volume 14; Issue 22; Pages: 5643

Background: Cell Division Cycle Associated 5 (CDCA5) plays a role in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signalling pathway involving cell division, cancer cell migration and apoptosis. This study aims to assess the prognostic and biologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1121bf03e18c2d8577d69b794c789637
https://doi.org/10.3390/cancers14225643

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The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma

Autor: Michael S. Toss, Emad A. Rakha, Andrew R. Green, Yousif A Kariri, Pavan L. Narasimha, Chitra Joseph, Nigel P. Mongan, Mansour Alsaleem, Maryam Althobiti, Abrar I. Aljohani, Sami Alsaeed

Publikováno v: Cancers
Volume 13
Issue 1
Cancers, Vol 13, Iss 80, p 80 (2021)

Simple Summary Breast cancer exhibits significant genetic and clinical heterogeneity. Given the importance of understanding tumour-immune interactions to enable the development of novel immunotherapies, identification of novel prognostic biomarkers i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ee8ec3942d74d81bb9ad7cf6b9674d

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Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype

Autor: Omar J. Mohammed, Michael S. Toss, Emad A. Rakha, Yousif A Kariri, Mohammed A. Aleskandarany, Andrew R. Green, Sasagu Kurozumi, Chitra Joseph

Publikováno v: Pathobiology : journal of immunopathology, molecular and cellular biology. 87(4)

Lymphovascular invasion (LVI) is associated with poor outcome in breast cancer (BC); however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex molecular pathways involving not only the interplay with the surrounding mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a0dc79df0fe5e29a538200616fdb5d
https://pubmed.ncbi.nlm.nih.gov/32645698

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Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer

Autor: Chitra Joseph, Andrew R. Green, Sultan N Sonbul, Sami Alsaeed, Mansour Alsaleem, Nigel P. Mongan, Stewart G. Martin, Ian O. Ellis, Takaaki Fujii, Christopher C. Nolan, Sasagu Kurozumi, Yousif A Kariri, Maria Diez-Rodriguez, Mohammed A. Aleskandarany, Simon J Johnston, Emad A. Rakha, Marian Pigera, Ken Shirabe

Publikováno v: Breast Cancer Research and Treatment. 172:61-68

BACKGROUND: Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re-epithelialisation in invasive carcinoma and therefore may play a key role in carcinogenesis and metastasis. We herein investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f387af3d0de86cfc8ad6c2fdec7d5d5
https://doi.org/10.1007/s10549-018-4891-y

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A key genomic subtype associated with lymphovascular invasion in invasive breast cancer

Publikováno v: British Journal of Cancer

BACKGROUND: Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b919514006551e3a3f45dcfdca8d0061
https://pubmed.ncbi.nlm.nih.gov/31114020

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