UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

Autor: Jiandong Sun, Yan Liu, Yousheng Jia, Xiaoning Hao, Wei ju Lin, Jennifer Tran, Gary Lynch, Michel Baudry, Xiaoning Bi

Publikováno v: eLife, Vol 7 (2018)

Accumulating evidence indicates that the lysosomal Ragulator complex is essential for full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in several developmental neurological diso

Externí odkaz: https://doaj.org/article/51a27ca63edd4cbf80708ca39e3cc1e0

Novel types of frequency filtering in the lateral perforant path projections to dentate gyrus

Autor: Julian Quintanilla, Yousheng Jia, Julie C. Lauterborn, Benedict S. Pruess, Aliza A. Le, Conor D. Cox, Christine M. Gall, Gary Lynch, Benjamin G. Gunn

Publikováno v: The Journal of Physiology. 600:3865-3896

Despite its evident importance to learning theory and models, the manner in which the lateral perforant path (LPP) transforms signals from entorhinal cortex to hippocampus is not well understood. The present studies measured synaptic responses in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585c750820fb40cdcc13fc870cd12c7a
https://doi.org/10.1113/jp283012

Identification of serum immunoglobulin M (IgM) of crucian carp (Carassius auratus gibelio) and immune response to cyprinid herpesvirus 2 infection

Autor: Shuran Wang, Haotian Wu, Longlong Wang, Pinhua Wang, Liqun Lu, Yousheng Jiang, Ye Zhang, Dan Xu

Publikováno v: Aquaculture and Fisheries, Vol 9, Iss 2, Pp 172-180 (2024)

Crucian carp (Carassius auratus gibelio), an extensively cultivated freshwater fish, was one of the model species for the study of fish immunology. Polyclonal antibodies were advantageous molecular tools for studying teleost immune system. Specifical

Externí odkaz: https://doaj.org/article/e2d44916632a497d899f56c09fed68dc

Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior

Autor: Rianne R. Campbell, Om Chitnis, Marcelo A. Wood, Dina P. Matheos, Gary Lynch, Philip H. Hwang, André O. White, Yasaman Alaghband, Monica Espinoza, Janine L. Kwapis, Yousheng Jia, Alberto J. López

Publikováno v: Addiction Biology. 24:403-413

Propensity to relapse, even following long periods of abstinence, is a key feature in substance use disorders. Relapse and relapse-like behaviors are known to be induced, in part, by re-exposure to drug-associated cues. Yet, while many critical nodes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72d53abde7e1c76e49d1ef87fde2d0ac
https://doi.org/10.1111/adb.12605

Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus

Autor: Christine M. Gall, Gary Lynch, Kwang-Mook Jung, Linda C. Palmer, Gavin Rumbaugh, Yousheng Jia, Daniele Piomelli, Weisheng Wang, Danielle T. Pham, Conor D. Cox

Publikováno v: Cerebral cortex (New York, N.Y. : 1991), vol 28, iss 7
Wang, W; Jia, Y; Pham, DT; Palmer, LC; Jung, K-M; Cox, CD; et al.(2018). Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. CEREBRAL CORTEX, 28(7), 2253-2266. doi: 10.1093/cercor/bhx126. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0bq5q49x

Endocannabinoids (ECBs) depress transmitter release at sites throughout the brain. Here, we describe another form of ECB signaling that triggers a novel form of long-term potentiation (LTP) localized to the lateral perforant path (LPP) which conveys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436fd6dfadba7bbf52b1c62c9e9324a8
https://doi.org/10.1093/cercor/bhx126