Výsledky vyhledávání - "Yousef Mzannar"

Supplementary Figures 1-4, Tables 1-2 from Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C–Mutant Cancers

Autor: Asfar S. Azmi, Anthony F. Shields, Ramzi M. Mohammad, Philip A. Philip, Dipesh Uprety, Hirva Mamdani, Yosef Landesman, Rafic Beydoun, Steve Kim, Mohammed Najeeb Al-Hallak, Yousef Mzannar, Sahar Bannoura, Rachel Sexton, Md. Hafiz Uddin, Amro Aboukameel, Yiwei Li, Misako Nagasaka, Husain Yar Khan

Supplementary Figure 1. XPO1-KRAS synthetic lethal interaction identified using the Slorth database. Supplementary Figure 2. KRAS WT, KRAS G12D and KRAS G12V MEF cell lines were refractory to growth inhibition by selinexor or MRTX1257 or their combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8baa9b3cbc288ae8a6d95ae6fcdd3d
https://doi.org/10.1158/2767-9764.22544132.v1

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Data from Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C–Mutant Cancers

The identification of molecules that can bind covalently to KRAS G12C and lock it in an inactive GDP-bound conformation has opened the door to targeting KRAS G12C selectively. These agents have shown promise in preclinical tumor models and clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718acd53ed3f4593886fb1335899dd3c
https://doi.org/10.1158/2767-9764.c.6550541

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Anticancer efficacy of KRASG12C inhibitors is potentiated by PAK4 inhibitor KPT9274 in preclinical models of KRASG12C mutant pancreatic and lung cancers

Publikováno v: bioRxiv

KRASG12C inhibitors have revolutionized the treatment landscape for cancer patients harboring the G12C mutant isoform of KRAS. With the recent FDA approval of sotorasib and adagrasib, patients now have access to more promising treatment options. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf004144758091e6e3046d4c1478a526
https://doi.org/10.1101/2023.03.27.534309

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Antineoplastic Properties of THCV, HHC and their anti-Proliferative effects on HPAF-II, MIA-paca2, Aspc-1, and PANC-1 PDAC Pancreatic Cell Lines

Autor: Tesfay Tesfatsion, Arianna Collins, Giovanni Ramirez, Yousef Mzannar, Husain Khan, Omar Aboukameel, Asfar Azmi, Prakash Jagtap, Kyle Ray, Westley Cruces

Publikováno v: ORCID

Cannabinoid receptors CB1 and CB2 are the primary endogenous receptors with which cannabinoids interact, inducing physiological and psychological effects. Although interactions with other receptors including TRPV1 and GPCR55, have been recognized in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370b42502666533525681241d2d2ec1b
https://doi.org/10.26434/chemrxiv-2022-v4zqc

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Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C-Mutant Cancers

Autor: Husain Yar Khan, Misako Nagasaka, Yiwei Li, Amro Aboukameel, Md. Hafiz Uddin, Rachel Sexton, Sahar Bannoura, Yousef Mzannar, Mohammed Najeeb Al-Hallak, Steve Kim, Rafic Beydoun, Yosef Landesman, Hirva Mamdani, Dipesh Uprety, Philip A. Philip, Ramzi M. Mohammad, Anthony F. Shields, Asfar S. Azmi

Publikováno v: Cancer Res Commun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9c14efed5348f093f2a93a3601a87b
https://pubmed.ncbi.nlm.nih.gov/35573474

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Connecting the Human Microbiome and Pancreatic Cancer

Autor: Rachel E. Sexton, Md Hafiz Uddin, Sahar Bannoura, Husain Yar Khan, Yousef Mzannar, Yiwei Li, Amro Aboukameel, Mohammad Najeeb Al-Hallak, Bayan Al-Share, Amr Mohamed, Misako Nagasaka, Bassel El-Rayes, Asfar S. Azmi

Publikováno v: Cancer metastasis reviewsReferences. 41(2)

Pancreatic cancer is a deadly disease that is increasing in incidence throughout the world. There are no clear causal factors associated with the incidence of pancreatic cancer; however, some correlation to smoking, diabetes and alcohol has been desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49861fa1b7643c7cd1606c9b76d8690
https://pubmed.ncbi.nlm.nih.gov/35536453

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Abstract 5315: Anti-tumor activity of KRASG12C inhibitors is enhanced when combined with Cdc42 effector p21-activated kinase 4 targeting agents

Autor: Husain Yar Khan, Sahar Bannoura, Hirva Mamdani, Amro Aboukameel, Yousef Mzannar, Yiwei Li, Mohammad Najeeb Al-Hallak, Ibrahim Azar, Steve Kim, Rafic Beydoun, Ramzi Mohammad, Yosef Landesman, Yue Zhang, Erkan Baloglu, William Senapedis, Ammar Sukari, Misako Nagasaka, Anthony Shields, Asfar S. Azmi

Publikováno v: Cancer Research. 82:5315-5315

Background: KRASG12C inhibitors sotorasib and adagrasib have shown impressive results in clinical studies. These inhibitors efficiently block KRAS downstream effectors such as RAF, MEK, and ERK/p-ERK. However, factors such as feedback reactivation or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfe3dbfb192688c2c5de34b29eb0f108
https://doi.org/10.1158/1538-7445.am2022-5315

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Correction to: Connecting the human microbiome and pancreatic cancer

Autor: Rachel E. Sexton, Md Hafz Uddin, Sahar Bannoura, Husain Yar Khan, Yousef Mzannar, Yiwei Li, Amro Aboukameel, Mohammad Najeeb Al-Hallak, Bayan Al-Share, Amr Mohamed, Misako Nagasaka, Bassel El-Rayes, Asfar S. Azmi

Publikováno v: Cancer and Metastasis Reviews. 41:333-333

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61ec851cc474ea07f249fdff06d28575
https://doi.org/10.1007/s10555-022-10037-3

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