Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Yousang, Gwack"'
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114951- (2024)
Summary: T helper (Th)17 cells mediate both protective anti-bacterial immune responses and autoimmune pathogenesis, but the distinct pathways regulating these Th17 responses remain unclear. Retinoid-related orphan receptor γ t (RORγt) is a master t
Externí odkaz:
https://doaj.org/article/5e984273321244f2a55ede05606508a8
Autor:
Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou, Pedram Shafiei-Jahani, Spyridon Hasiakos, Jacob Painter, Sonal Srikanth, Yousang Gwack, Omid Akbari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Ca2+ entry via Ca2+ release-activated Ca2+ (CRAC) channels is a predominant mechanism of intracellular Ca2+ elevation in immune cells. Here we show the immunoregulatory role of CRAC channel components Orai1 and Orai2 in Group 2 innate lympho
Externí odkaz:
https://doaj.org/article/6ea722380e2340a785089d7d327b7642
Autor:
Anthony Nguyen, Youngjae Sung, Sung Hee Lee, Charlotte Ellen Martin, Sonal Srikanth, Wei Chen, Mo K. Kang, Reuben H. Kim, No-Hee Park, Yousang Gwack, Yong Kim, Ki-Hyuk Shin
Publikováno v:
Cells, Vol 12, Iss 18, p 2225 (2023)
Emerging evidence indicates that intracellular calcium (Ca2+) levels and their regulatory proteins play essential roles in normal stem cell proliferation and differentiation. Cancer stem-like cells (CSCs) are subpopulations of cancer cells that retai
Externí odkaz:
https://doaj.org/article/b14d999550cc4a078bcec75e8a8e8934
Autor:
Ji-Hee Kim, Kyu-Hee Hwang, Bao T. N. Dang, Minseob Eom, In Deok Kong, Yousang Gwack, Seyoung Yu, Heon Yung Gee, Lutz Birnbaumer, Kyu-Sang Park, Seung-Kuy Cha
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Perturbations of Ca2+ signaling in podocytes may deteriorate kidney function and eventually lead to proteinuria. Here the authors show that insulin can affect the function of the calcium regulator Ora1 in podocytes, which is critical for maintaining
Externí odkaz:
https://doaj.org/article/bc2e1cc7ee1947fb859dbac6a5b38a43
Autor:
Beibei Wu, Laura Rice, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth, Yousang Gwack, Sinisa Savic
Publikováno v:
eLife, Vol 10 (2021)
CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to h
Externí odkaz:
https://doaj.org/article/3bc52deffd5148cea866655819e240e0
Autor:
Beibei Wu, Jin Seok Woo, Pamela Vila, Marcus Jew, Jennifer Leung, Zuoming Sun, Sonal Srikanth, Yousang Gwack
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109603- (2021)
Summary: Sustained activation of the Ca2+-release-activated Ca2+ (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of ORAI1, the
Externí odkaz:
https://doaj.org/article/40b835d00ea54b0783f02482bcf0b183
Autor:
Hyewon Choi, Sonal Srikanth, Elisa Atti, Flavia Q. Pirih, Jeanne M. Nervina, Yousang Gwack, Sotirios Tetradis
Publikováno v:
Bone Reports, Vol 8, Iss , Pp 147-155 (2018)
Osteoblast lineage cells, a group of cells including mesenchymal progenitors, osteoblasts, and osteocytes, are tightly controlled for differentiation, proliferation and stage-specific functions in processes of skeletal development, growth and mainten
Externí odkaz:
https://doaj.org/article/3e5b9b5788c048aea47dd4be27a7f263
Autor:
Drake Winslow Williams, Katie Ho, Allison Lenon, Sol Kim, Terresa Kim, Yousang Gwack, Reuben H. Kim
Publikováno v:
J Bone Miner Res
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a detrimental intraoral lesion that occurs in patients with long-term or high-dose use of anti-resorptive agents such as bisphosphonates. Tooth extraction is a known risk factor for BRONJ, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5744c12403e48eb2dc48b6bfd5322150
https://doi.org/10.1002/jbmr.4614
https://doi.org/10.1002/jbmr.4614
Autor:
Wencan Zhang, Xu Cao, Xiancai Zhong, Hongmin Wu, Yun Shi, Mingye Feng, Yi-Chang Wang, David Ann, Yousang Gwack, Yate-Ching Yuan, Weirong Shang, Zuoming Sun
Publikováno v:
Proceedings of the National Academy of Sciences. 120
T cell activation stimulates substantially increased protein synthesis activity to accumulate sufficient biomass for cell proliferation. The protein synthesis is fueled by the amino acids transported from the environment. Steroid nuclear receptor coa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::617b5770acf5e0c70c6b5831dfbcebe6
https://doi.org/10.1073/pnas.2221352120
https://doi.org/10.1073/pnas.2221352120
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 208, iss 6
Activation of the Ca2+ release–activated Ca2+ (CRAC) channel is crucial for T cell functions. It was recently shown that naked cuticle homolog 2 (NKD2), a signaling adaptor molecule, orchestrates trafficking of ORAI1, a pore subunit of the CRAC cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef59679600221f0e18ca0b428112215c
https://doi.org/10.4049/jimmunol.2100871
https://doi.org/10.4049/jimmunol.2100871