Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Younong Yu"'
Autor:
James I. Fells, Wensheng Yu, Younong Yu, Richard J. O. Barnard, Christine C. Chung, Bonnie J. Howell, Shouning Xu, Daniel J. Klein, Joseph A. Kozlowski, Joseph L. Duffy, Dane Clausen, Jian Liu, M. Katharine Holloway, Robert W. Myers, Guoxin Wu, Takao Suzuki, Lin Deng, Jin Wu, Ming Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:4709-4729
We describe the discovery of histone deacetylase (HDACs) 1, 2, and 3 inhibitors with ethyl ketone as the zinc-binding group. These HDACs 1, 2, and 3 inhibitors have good enzymatic and cellular activity. Their serum shift in cellular potency has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c8b7b2d8a7b239d36c3d11df82ab88
https://doi.org/10.1021/acs.jmedchem.0c02150
https://doi.org/10.1021/acs.jmedchem.0c02150
Autor:
Alexei V. Buevich, Ming Wang, Shane W. Krska, Milana Maletic, Min Liu, Eric Streckfuss, Younong Yu, Robert W. Myers, Jian Liu, Petr Vachal, Kevin D. Dykstra, Joseph A. Kozlowski
Publikováno v:
ACS Med Chem Lett
[Image: see text] An integrated workflow has been established that enables the synthesis, purification, and subsequent biological testing of compound libraries on a microgram scale. This approach utilizes mass directed preparative HPLC in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e258e2554547baddad36c5f86e745eda
https://doi.org/10.1021/acsmedchemlett.0c00596
https://doi.org/10.1021/acsmedchemlett.0c00596
Autor:
Wensheng Yu, Deyou Sha, Abdul-Basit Alhassan, Joseph Kelly, Joseph L. Duffy, M. Katharine Holloway, Bonnie J. Howell, Joseph A. Kozlowski, Jian Liu, Richard J. O. Barnard, Milana Maletic, Daniel J. Klein, Scott E. Wolkenberg, Steve S. Carroll, Younong Yu
Publikováno v:
ACS Med Chem Lett
[Image: see text] The selectivity of histone deacetylase inhibitors (HDACis) is greatly impacted by the zinc binding groups. In an effort to search for novel zinc binding groups, we applied a parallel medicinal chemistry (PMC) strategy to quickly syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cfd7d537a63ac4577faba274ff15e5
https://doi.org/10.1021/acsmedchemlett.0c00462
https://doi.org/10.1021/acsmedchemlett.0c00462
Autor:
Joseph L. Duffy, James I. Fells, Younong Yu, Bonnie J. Howell, Hyunjin M. Kim, Wensheng Yu, Dane Clausen, M. Katharine Holloway, Christine C. Chung, Robert W. Myers, Jin Wu, Richard J. O. Barnard, Daniel J. Klein, Joseph A. Kozlowski, Steve S. Carroll, Guoxin Wu, Jian Liu, Joseph Kelly
Publikováno v:
ACS Med Chem Lett
[Image: see text] HIV persistence in latently infected, resting CD4(+) T cells is broadly considered a barrier to eradicate HIV. Activation of the provirus using latency-reversing agents (LRAs) followed by immune-mediated clearance to purge reservoir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525b4192080895b98514a52d14d59d11
https://europepmc.org/articles/PMC7357218/
https://europepmc.org/articles/PMC7357218/
Autor:
Jiaqiang Cai, Jiayi Xu, Ying-Duo Gao, Wang James J-S, Deodial Guiadeen, Wensheng Yu, Arto D. Krikorian, Joseph A. Kozlowski, Jie Zhang-Hoover, Hao Wu, Sobhana Babu Boga, Jeremy Presland, Chad Bennett, Xiaolei Gao, Charles G. Garlisi, Kevin M. Maloney, Shilan Liu, My Sam Mansueto, Joseph Kelly, Abdul-Basit Alhassan, Alexandra Hicks, Rajan Anand, Jian Liu, Erica Leccese, Philip E. Brandish, Ronald M. Kim, Peter Stivers, Joseph L. Duffy, Sriram Tyagarajan, Thierry O. Fischmann, Oleg Selyutin, Younong Yu, Ian Knemeyer, Zangwei Xu, Chundao Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition, and for the treatment of B cell related diseases. Many BTK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da5ce66383962022d93e832cf2c0143
https://pubmed.ncbi.nlm.nih.gov/32738973
https://pubmed.ncbi.nlm.nih.gov/32738973
Autor:
Li-Kang Zhang, Younong Yu, Steven L. Colletti, Alexei V. Buevich, Haiqun Tang, Guoqing Li, Zhi-Cai Shi, Petr Vachal
Publikováno v:
Journal of the American Chemical Society. 140:6797-6800
Targeting tryptophan is a promising strategy to achieve high levels of selectivity for peptide or protein modification. A chemoselective peptide modification method via photocatalytic tryptophan β-position conjugation has been discovered. This trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d3349ea2021360c4907ac2ceef7a75
https://doi.org/10.1021/jacs.8b03973
https://doi.org/10.1021/jacs.8b03973
Autor:
Deodial Guiadeen, Shilan Liu, Jian Liu, Charles G. Garlisi, Arto D. Krikorian, Ronald M. Kim, Ying-Duo Gao, Peter Stivers, Hugh Y. Zhu, Alan B. Cooper, Rajan Anand, Philip E. Brandish, Younong Yu, Nathan Bays, Jiaqiang Cai, Ian Knemeyer, Erica Leccese, Zangwei Xu, Kevin M. Maloney, Alexandra Hicks, Sobhana Babu Boga, Chundao Yang, Joseph A. Kozlowski, My Sam Mansueto, Hao Wu, Thierry O. Fischmann, Desai Jagdish A, Jeremy Presland, Abdul-Basit Alhassan, Xiaolei Gao, Wang James J-S
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3939-3943
8-Amino-imidazo[1,5- a ]pyrazine-based Bruton’s tyrosine kinase (BTK) inhibitors, such as 6 , exhibited potent inhibition of BTK but required improvements in both kinase and hERG selectivity (Liu et al., 2016; Gao et al., 2017). In an effort to mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374dfa7e3c822671c1df7ad53a01c129
https://doi.org/10.1016/j.bmcl.2017.03.040
https://doi.org/10.1016/j.bmcl.2017.03.040
Autor:
Jian Liu, Kelly, Joseph, Wensheng Yu, Clausen, Dane, Younong Yu, Hyunjin Kim, Duffy, Joseph L., Chung, Christine C., Myers, Robert W., Carroll, Steve, Klein, Daniel J., Fells, James, Holloway, M. Katharine, Wu, Jin, Wu, Guoxin, Howell, Bonnie J., Barnard, Richard J. O., Kozlowski, Joseph A.
Publikováno v:
ACS Medicinal Chemistry Letters; 7/9/2020, Vol. 11 Issue 7, p1476-1483, 8p
Autor:
Sobhana Babu Boga, Ying-Duo Gao, Jiaqiang Cai, Thierry O. Fischmann, Wensheng Yu, Chundao Yang, Oleg Selyutin, Shilan Liu, Nathan Bays, Peter Stivers, Hugh Y. Zhu, Joeseph A. Kozlowski, Philip E. Brandish, Rajan Anand, Hao Wu, Ronald M. Kim, James Wang, Alan B. Cooper, Younong Yu, Erica Leccese, Ian Knemeyer, Zangwei Xu, Deodial Guiadeen, Kevin M. Maloney, Jie Zhang-Hoover, Alexandra Hicks, Charles G. Garlisi, Jeremy Presland, My Sam Mansueto, Abdul-Basit Alhassan, Xiaolei Gao, Arto D. Krikorian, Jian Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(6)
We report the design and synthesis of a series of novel Bruton's Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket. This series of compounds has demonstrated much improved off-target selectivities including adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85aa9014e3762fe9f863175d58d9b47e
https://pubmed.ncbi.nlm.nih.gov/28254166
https://pubmed.ncbi.nlm.nih.gov/28254166
Autor:
Joseph A. Kozlowski, Hao Wu, Chundao Yang, Jie Zhang-Hoover, Thierry O. Fischmann, Jeremy Presland, Sobhana Babu Boga, Allard Kaptein, Philip E. Brandish, Ying-Duo Gao, Kevin M. Maloney, Arto D. Krikorian, Shilan Liu, My Sam Mansueto, Abdul-Basit Alhassan, Henry M. Vaccaro, Diep Vu-Pham, Erica Leccese, Ronald M. Kim, Alexandra Hicks, Alan B. Cooper, Charles G. Garlisi, Jian Liu, Nathan Bays, Hans C.A. Raaijmakers, Jos de Man, Peter Stivers, Wang James J-S, Deodial Guiadeen, Xiaolei Gao, Viktor Hornak, Younong Yu, Ian Knemeyer, Zangwei Xu
Publikováno v:
ACS medicinal chemistry letters. 7(2)
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition and for the treatment of B cell related diseases. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef21521484b31fc31f3730ab2c22387
https://pubmed.ncbi.nlm.nih.gov/26985298
https://pubmed.ncbi.nlm.nih.gov/26985298