Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response

Autor: Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I. Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M. Domingos, Rémy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walter, Alvaro Glavic, Guido Kroemer, Claudio Hetz

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively cont

Externí odkaz: https://doaj.org/article/41bd77e35d0d4d3fba7541fc5ffc6412

A chosen STING with a PERKy trail

Autor: Younis Hazari, Claudio Hetz

Publikováno v: Nature cell biology. 24(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2659d806e798c52132adb218e726ac
https://pubmed.ncbi.nlm.nih.gov/35501369

Autophagy in hepatic adaptation to stress

Autor: Guido Kroemer, José Manuel Bravo-San Pedro, Lorenzo Galluzzi, Claudio Hetz, Younis Hazari

Publikováno v: Journal of Hepatology. 72:183-196

Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence indicates that autophagy operate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cb46cad0c5fbd3f36dbe990207e2c5
https://doi.org/10.1016/j.jhep.2019.08.026

Author Correction: IRE1α governs cytoskeleton remodeling and cell migration through a direct interaction with filamin A

Autor: Rene L. Vidal, Hery Urra, Felipe A. Court, Celia M Limia, Daniel R. Henríquez, Eric Chevet, Eduardo Pulgar, Ling Qi, Sebastián Alvarez-Rojas, Ryoko Akai, Alvaro Glavic, Andrés Couve, Amado Carreras-Sureda, Claudia A Rivera, Ricardo Figueroa, Takao Iwawaki, Christian Gonzalez-Billault, Emiliano Molina, David Villarroel-Campos, Younis Hazari, José Cánovas, Miguel L. Concha, Claudio Hetz, Diego A. Rodriguez

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2021, 23 (5), pp.577. ⟨10.1038/s41556-021-00673-2⟩
Nature Cell Biology, 2021, 23 (5), pp.577. ⟨10.1038/s41556-021-00673-2⟩

In the version of this Article originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions of the Article.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85eb3afbd9512ec0112a89bcb9ba2c77
https://hal.archives-ouvertes.fr/hal-03248167

Expression and purification of p70ΔCT 104 S6 K, a 72 kDa c-terminal truncated p70S6 kinase-GST fusion protein in bacterial expression system

Autor: Irfana Reshi, Younis Hazari, Khalid Majid Fazili, Mudasir Habib

Publikováno v: International Journal of Biological Macromolecules. 102:625-629

The p70ΔCT104 S6K is a 421 amino acid residue long truncated form of p70S6 kinase, with 104 amino acids residues cleaved from the carboxyl terminal end of the original protein. The p70ΔCT104 S6K was cloned in E. coli DH5α and successfully expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fd24691c8619ff2787b4167befa4218
https://doi.org/10.1016/j.ijbiomac.2017.04.066