The molecular and cellular mechanisms of 1,2-dichlorobenzene induced liver injury in Fischer-344 and Sprague-Dawley rats

Autor: Younis, Husam S.

1,2-Dichlorobenzene (1,2-DCB), an industrial solvent, is a potent hepatotoxicant in Fischer-344 (F-344) rats. Bioactivation of 1,2-DCB by cytochrome P450 enzymes in the liver and subsequent activation of Kupffer cells (KC), the resident liver macroph

Externí odkaz: http://hdl.handle.net/10150/290190

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Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment

Autor: Zou, Wei, Roth, Robert A., Younis, Husam S., Burgoon, Lyle D., Ganey, Patricia E.

Publikováno v: In Toxicology 2010 272(1):32-38

Contributors

Autor: Ajithdoss, D.K., Al-Humadi, Nabil, Amuzie, C.J., Attar, Mayssa, Aulbach, Adam D., Boersen, Nathan, Bolger, Gordon, Brown, Jennifer G., Chang, T.T.A., Chanut, Franck Jacques-Antoine, Cheng, Z., Colagiovanni, Dorothy B., Colerangle, John B., Collins, Roger, Cristofori, Patrizia, Denny, Kevin H., Dill-Okubo, J., Ennulat, Daniela, Faqi, Ali S., Farmer, John T., Frantz, Stephen, Freshwater, Les, Gauvin, David V., Goud, N.S., Green, M.D., Henry, Scott P., Hoberman, Alan, Hui, Ho-Wah, Hui, Julia Y., Ji, A.Y., Johnson, Colleen, Kile, J.W., Kim, Tae-Won, Koch, Elisabeth, Kornbrust, Douglas, Kulshreshtha, V., Learn, D.B., LeBaron, Mathew J., Levin, Arthur A., Lewis, Elise, Licollari, Albert, Li, X.P., Loo, Deryk, Luhrs, Keith A., Martini, Austin, McCormick, D.L., Meyer-Tamaki, K.B., Nicolette, John, O'Carroll, Andrew, Oh, Hyesun Helena, Oyejide, L., Peraza, Marjorie A., Plassmann, Stephanie, Qiao, H.W., Ramos, Meg Ferrell, Rehagen, D., Resendez, J.C., Schultze, A. Eric, Seals, Jennifer R., Settivari, Raja S., Slauter, Ric, Stahl, Kurt, Stewart, C.W., Stump, Donald, Surapaneni, Sekhar, Templin, Michael, Toltin, Abigail, Vidmar, Tom, Vrbanac, Jim, Wang, Z.J., Whiteley, Laurence O., Wijeyesakere, Sanjeeva, Wrzesinski, Claudia, Xu, Jie, Yang, Ping, Yoder, Lisa, Younis, Husam S., Zhang, Y.M., Zimmermann, Zachary J.

Publikováno v: In A Comprehensive Guide to Toxicology in Nonclinical Drug Development Edition: Third Edition. 2024:xv-xvi