Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Younhee Cho"'
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e54617 (2024)
BackgroundDepressive disorders have substantial global implications, leading to various social consequences, including decreased occupational productivity and a high disability burden. Early detection and intervention for clinically significant depre
Externí odkaz:
https://doaj.org/article/d37ee7138f374524b7ada727ed20ce9c
Autor:
Christopher B. Lietz, Ekaterina Deyanova, Younhee Cho, Jon Cordia, Sarah Franc, Sally Kabro, Steven Wang, David Mikolon, Douglas D. Banks
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTDespite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclo
Externí odkaz:
https://doaj.org/article/4708d09120bb4b4ebcea29f7c90344fa
Publikováno v:
Frontiers in Psychology, Vol 14 (2023)
IntroductionFor decades, a substantial body of research has confirmed the subjective nature of pain. Subjectivity seems to be integrated into the concept of pain but is often confined to self-reported pain. Although it seems likely that past and curr
Externí odkaz:
https://doaj.org/article/71b9fa6a4d774afe864bb2b7e11a3d4b
Autor:
Younhee Cho, Xin Zhang, Kristine Faye R. Pobre, Yu Liu, David L. Powers, Jeffery W. Kelly, Lila M. Gierasch, Evan T. Powers
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 321-333 (2015)
The folding fate of a protein in vivo is determined by the interplay between a protein’s folding energy landscape and the actions of the proteostasis network, including molecular chaperones and degradation enzymes. The mechanisms of individual comp
Externí odkaz:
https://doaj.org/article/91b493a5c85e427482a2079d643a323c
Publikováno v:
Intelligent Human Computer Interaction ISBN: 9783031271984
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed38bc379c5aba0585f0f4272a895d2b
https://doi.org/10.1007/978-3-031-27199-1_17
https://doi.org/10.1007/978-3-031-27199-1_17
Publikováno v:
SAGE Open, Vol 14 (2024)
Energy poverty, defined as the inability of households to afford adequate heating or cooling, is worsened by anthropogenic climate change, leading to increased energy demand and indoor comfort challenges. This study addresses a gap in summer fuel pov
Externí odkaz:
https://doaj.org/article/0fa2886cc9114c9ca298b4ce58dd9259
Autor:
Stephen Helmke, Mathew S. Maurer, Aleksandra Baranczak, Evelyn M. Horn, Jeffery W. Kelly, Sergio Teruya, Younhee Cho
Placebo-controlled clinical trials are useful for identifying the dose of a drug candidate that produces a meaningful clinical response in a patient population. Currently, Pfizer, Inc. is enrolling a 400-person clinical trial to test the efficacy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8649a83f01221152571121b4db6642c
Autor:
Younhee Cho, Vladimir Spasojevic, Jon F. Cordia, Douglas D. Banks, Sarah Franc, Sun Jeonghoon
Publikováno v:
Protein Science. 27:2073-2083
Inert co-solutes, or excipients, are often included in protein biologic formulations to adjust the tonicity of liquid dosage forms intended for subcutaneous delivery. Despite the low concentration of their use, many of these excipients alter protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc7970de6947ddceb8f3575789daa301
https://doi.org/10.1002/pro.3518
https://doi.org/10.1002/pro.3518
Autor:
Jerry C. Chang, Anjana Sinha, Yue Ming Li, Xianzhong Wu, Paul Greengard, Weilin Sun, Subhash C. Sinha, Katherina Gindinova, Peng Xu, Younhee Cho, Jeffery W. Kelly
Publikováno v:
ACS Med Chem Lett
[Image: see text] Tafamidis, 1, a potent transthyretin kinetic stabilizer, weakly inhibits the γ-secretase enzyme in vitro. We have synthesized four amide derivatives of 1. These compounds reduce production of the Aβ peptide in N2a695 cells but do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af916c03ac50a52a3c659ad609ba223
https://pubmed.ncbi.nlm.nih.gov/33062181
https://pubmed.ncbi.nlm.nih.gov/33062181
Autor:
Jana Hladílková, Pavel Jungwirth, Joachim Dzubiella, Jan Heyda, Kelvin B. Rembert, Halil I. Okur, Paul S. Cremer, Younhee Cho
Publikováno v:
The Journal of Physical Chemistry B. 121:1997-2014
Ions differ in their ability to salt out proteins from solution as expressed in the lyotropic or Hofmeister series of cations and anions. Since its first formulation in 1888, this series has been invoked in a plethora of effects, going beyond the ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cd2a3ce4fdc0666072416208338a2a
https://doi.org/10.1021/acs.jpcb.6b10797
https://doi.org/10.1021/acs.jpcb.6b10797