Výsledky vyhledávání - "Youngran Park"

A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening

Autor: Zheng Cheng Yu, Jin Gyoung Jung, Ie Ming Shih, Geoff Shimberg, Yeh Wang, Vamsi Parimi, Ryoichi Asaka, Yun Chen, Wei-Hung Jung, Stephanie Gaillard, Wenjing Shen, Alicja Tomaszewski, Tian Li Wang, Youngran Park

Publikováno v: Lab Invest

Endometrium-related malignancies including uterine endometrioid carcinoma, ovarian clear cell carcinoma and ovarian endometrioid carcinoma are major types of gynecologic cancer, claiming more than 13,000 women’s lives annually in the United States.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3c87a34a9feee2ce42950b893f2787
https://doi.org/10.1038/s41374-021-00624-3

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TORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma

Autor: Barbara S. Slusher, Jill P. Mesirov, Scott L. Pomeroy, Charles G. Eberhart, Brad Poore, Khoa Pham, Tenley C. Archer, Madison James, Rachael E. Maynard, Jesse Alt, Eric H. Raabe, Youngran Park, Allison Hanaford, Pablo Tamayo

Publikováno v: Cancer Lett

Medulloblastoma is the most common malignant pediatric brain tumor. Tumors having high levels of c-MYC have the worst clinical prognosis, with only a minority of patients surviving. To address this unmet clinical need, we generated a human neural ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27115eb2321a983b201ed1a184ddd66e
https://doi.org/10.1016/j.canlet.2021.02.001

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Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy

Autor: Youngran Park, Zheng Cheng Yu, Ayse Ayhan, Tian Li Wang, Raghavendra A. Shamanna, Ie Ming Shih, Sonia Franco, Akila N. Viswanathan, Michael M. Seidman, Vilhelm A. Bohr, M. Herman Chui, Marina A. Bellani, Stephanie Gaillard, Yohan Suryo Rahmanto, Anthony K.L. Leung

Publikováno v: Clin Cancer Res

Purpose: Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin remodeling complex, are detected in various types of human malignancies. Loss of ARID1A compromises DNA damage repair. The induced DNA damage burden may increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db531e63d7ab7e0e4ee7641129963dee
https://doi.org/10.1158/1078-0432.ccr-18-4222

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The SARS-CoV-2 RNA interactome

Autor: Jeesoo Kim, Jong-Seo Kim, Youngran Park, Yeon Choi, V. Narry Kim, Sungyul Lee, Ahyeon Son, Kyung-Min Lee, Young-suk Lee

Publikováno v: Molecular Cell

SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the SARS-CoV-2 RNA interactome, we here develop a robust ribonucleoprotein (RNP) capt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee76e94c27fbd3b797bc1a239009715
https://pubmed.ncbi.nlm.nih.gov/33989516

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Abstract 3904: The novel combination of PAC-1 and ONC201 circumvent H3K27M-driven pro-survival gene expression to induce DIPG cell death

Autor: Michael A. Koldobskiy, Jeffery Rubens, Antje Arnold, Ashlyn Parkhurst, Youngran Park, Eric H. Raabe, Charles G. Eberhart

Publikováno v: Cancer Research. 80:3904-3904

Diffuse Intrinsic Pontine Gliomas (DIPGs) are universally fatal tumors, resistant to the cytotoxic effects of all known therapies. We aim to better understand the mechanisms contributing to this resistance to design new combination therapies that wil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a80e48c1b93ea4d5e2d54aa99050eeb0
https://doi.org/10.1158/1538-7445.am2020-3904

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Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue

Autor: Seung-Young, Roh, Ji Yeon, Kim, Hyo Kyeong, Cha, Hye Young, Lim, Youngran, Park, Kwang-No, Lee, Jaemin, Shim, Jong-Il, Choi, Young-Hoon, Kim, Gi Hoon, Son

Publikováno v: Molecules and Cells

The sinus node (SN) is located at the apex of the cardiac conduction system, and SN dysfunction (SND)—characterized by electrical remodeling—is generally attributed to idiopathic fibrosis or ischemic injuries in the SN. SND is associated with inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::287847de9631c52da42b78b0fa68eb6c
https://pubmed.ncbi.nlm.nih.gov/32235021

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Abstract 3182: A human neural stem cell glial brain tumor model identifies the relative contribution of different oncogenic elements to malignant transformation

Autor: Ping An, Charles G. Eberhart, Youngran Park, Eric H. Raabe, Dacheng Ding

Publikováno v: Cancer Research. 78:3182-3182

Diffuse intrinsic pontine glioma (DIPG) is an invasive malignancy of the brainstem that accounts for greater than 80% of pediatric brainstem gliomas. In the past 40 years, there have been no significant advances in DIPG treatments and survival, so it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c4efd871442d64221c6ed5b3fbb7ad7
https://doi.org/10.1158/1538-7445.am2018-3182

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