Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Youngnim Shin"'
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α. This study aims to elucidate the
Externí odkaz:
https://doaj.org/article/53288813e39e423c92d6ad8903c7accb
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain. Methods The candidate molecule
Externí odkaz:
https://doaj.org/article/83aad81059cc4e3cb05022f60fa59583
Autor:
Je-Hwang Ryu, Chang-Suk Chae, Ji-Sun Kwak, Hwanhee Oh, Youngnim Shin, Yun Hyun Huh, Choong-Gu Lee, Yong-Wook Park, Churl-Hong Chun, Young-Myeong Kim, Sin-Hyeog Im, Jang-Soo Chun
Publikováno v:
PLoS Biology, Vol 12, Iss 6, p e1001881 (2014)
Rheumatoid arthritis (RA) is a systemic autoimmune disorder that manifests as chronic inflammation and joint tissue destruction. However, the etiology and pathogenesis of RA have not been fully elucidated. Here, we explored the role of the hypoxia-in
Externí odkaz:
https://doaj.org/article/4e730e1e91e340d18d4720b3e8a542be
Background. This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain. Methods: The candidate molecule, STING
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4330a207db88c9e9af496197455fc71
https://doi.org/10.21203/rs.3.rs-2303685/v1
https://doi.org/10.21203/rs.3.rs-2303685/v1
Autor:
Jeong-In Yang, Jung-Ah Kang, Youngnim Shin, Kyu-Young Sim, Ji-Sun Kwak, In Jung Jung, Sung-Gyoo Park, Jang-Soo Chun, Sang-Heon Park, Seul Ki Kim
Publikováno v:
Experimental & Molecular Medicine
Zinc is a trace element that is essential for immune responses. Therefore, changes in cellular zinc levels in specific immune cells may influence inflammatory autoimmune diseases, such as rheumatoid arthritis (RA). However, the regulation of zinc mob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce7a7d9902be0122fa5892bd92c383e
http://europepmc.org/articles/PMC8102558
http://europepmc.org/articles/PMC8102558
Publikováno v:
Osteoarthritis and cartilage. 29(4)
Summary Objective Osteoarthritic cartilage destruction can be regulated by the balance between proteases and anti-proteases. Here, we sought to identify novel cellular protease inhibitors associated with osteoarthritis (OA) pathogenesis. Methods Cand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61576633a9c114f5b25b75d5d4e5769e
https://pubmed.ncbi.nlm.nih.gov/33485930
https://pubmed.ncbi.nlm.nih.gov/33485930
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-13 (2019)
Cell Death and Disease, Vol 10, Iss 2, Pp 1-13 (2019)
We previously showed that mice with knockout of Cytl1, a functionally uncharacterized cytokine candidate, exhibit normal endochondral ossification and long-bone development. Here, we investigated the potential functions of CYTL1 in bone homeostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62530584359aa2616de3356663e6aae
https://doi.org/10.1038/s41419-018-1284-4
https://doi.org/10.1038/s41419-018-1284-4
Autor:
Youngnim Shin, Jin-Hong Kim, Churl-Hong Chun, Jang-Soo Chun, Chul-Won Ha, Yongsik Cho, Yoonkyung Won
Publikováno v:
Annals of the Rheumatic Diseases
ObjectiveThe zinc-ZIP8-MTF1 axis induces metallothionein (MT) expression and is a catabolic regulator of experimental osteoarthritis (OA) in mice. The main aim of the current study was to explore the roles and underlying molecular mechanisms of MTs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33ac38ff43ed5112a96f3dfb3471178
https://doi.org/10.1136/annrheumdis-2015-208406
https://doi.org/10.1136/annrheumdis-2015-208406
Publikováno v:
Osteoarthritis and Cartilage. 24:134-145
Summary Objective Hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis in chondrocytes serve as catabolic regulators of osteoarthritic cartilage destruction by regulating the expression of catabolic factor genes. We explored possible crosst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82577b7446dcd6c0df14c648c8836775
https://doi.org/10.1016/j.joca.2015.07.016
https://doi.org/10.1016/j.joca.2015.07.016
Publikováno v:
Osteoarthritis and Cartilage. 28:S100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac58212e72ad7e07fea7dffdf050aac6
https://doi.org/10.1016/j.joca.2020.02.155
https://doi.org/10.1016/j.joca.2020.02.155