Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Youngmin A. Lee"'
Autor:
Youngmin A. Lee, Luke A. Noon, Kemal M. Akat, Maria D. Ybanez, Ting-Fang Lee, Marie-Luise Berres, Naoto Fujiwara, Nicolas Goossens, Hsin-I Chou, Fatemeh P. Parvin-Nejad, Bilon Khambu, Elisabeth G. M. Kramer, Ronald Gordon, Cathie Pfleger, Doris Germain, Gareth R. John, Kirk N. Campbell, Zhenyu Yue, Xiao-Ming Yin, Ana Maria Cuervo, Mark J. Czaja, M. Isabel Fiel, Yujin Hoshida, Scott L. Friedman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further es
Externí odkaz:
https://doaj.org/article/8a7df5ad28dd4b319f2772959888bbcb
Autor:
Wei Kelly Wu, Rei Ukita, Yatrik J. Patel, Michael Cortelli, Vincent Q. Trinh, Ioannis A. Ziogas, Sean A. Francois, Meredith Mentz, Nancy L. Cardwell, Jennifer R. Talackine, William M. Grogan, John W. Stokes, Youngmin A. Lee, Jinho Kim, Sophoclis P. Alexopoulos, Matthew Bacchetta
Publikováno v:
Hepatology.
Autor:
Vincent Quoc-Huy Trinh, Ting-Fang Lee, Sara Lemoinne, Kevin C. Ray, Maria D. Ybanez, Takuma Tsuchida, James K. Carter, Judith Agudo, Brian D. Brown, Kemal M. Akat, Scott L. Friedman, Youngmin A. Lee
Organ homeostasis is maintained by regulated proliferation of distinct cell populations. In mouse liver, cyclin D1-positive hepatocytes in the midlobular zone repopulate the parenchyma at a constant rate to preserve liver homeostasis. The mitogenic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8637eeac0ec1514a20feba18a720fe50
https://doi.org/10.1101/2023.03.03.531042
https://doi.org/10.1101/2023.03.03.531042
Autor:
Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Ramona Graves-Deal, Vincent Q. Trinh, Marisol A. Ramirez, Yoojin Sohn, Abigail C. Neininger, Nilay Taneja, Eliot T. McKinley, Hiroaki Niitsu, Zheng Cao, Rachel Evans, Sarah E. Glass, Kevin C. Ray, William H. Fissell, Salisha Hill, Kristie Lindsey Rose, Won Jae Huh, Mary Kay Washington, Gregory Daniel Ayers, Dylan T. Burnette, Shivani Sharma, Leonard H. Rome, Jeffrey L. Franklin, Youngmin A. Lee, Qi Liu, Robert J. Coffey
Publikováno v:
Nature Cell Biology
Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct
Autor:
Scott L. Friedman, Youngmin A. Lee
Publikováno v:
J Intern Med
Non-alcoholic fatty liver disease is comprised of either simple steatosis (non-alcoholic fatty liver, (NAFL)) or a more advanced inflammatory and fibrogenic stage (non-alcoholic steatohepatitis (NASH). NASH affects a growing proportion of the global
Publikováno v:
Am J Pathol
A unique and complex microstructure underlies the diverse functions of the liver. Breakdown of this organization, as occurs in fibrosis and cirrhosis, impairs liver function and leads to disease. The role of integrin β1 was examined both in establis
Autor:
Arun J. Sanyal, Claudia P. Oliveira, Andrew V. Uzilov, Beatriz Minguez, Huan Wang, Suzanne Faure-Dupuy, Sara Torrecilla, Helen L. Reeves, Jean-François Dufour, Mathias Heikenwalder, Carmen Andreu-Oller, Flair José Carrilho, Charissa Chang, Catherine E. Willoughby, Marta Piqué-Gili, Scott L. Friedman, Leow Wei-Qiang, Svenja Schuehle, Judit Peix, Carla Montironi, Paolo Boffetta, Josep M. Llovet, Stephanie Roessler, Roser Pinyol, Peter Schirmacher, Miguel Torres-Martin, Patricia Taik, Venancio Avancini Ferreira Alves, Youngmin A. Lee, Tobias Riedl, Pierluigi Ramadori, Daniela Sia, Agrin Moeini, Anja Lachenmayer, Swan N. Thung
Publikováno v:
Journal of hepatology. 75(4)
BACKGROUND AND AIMS Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We aimed to identify unique molecular traits characterising NASH-HCC compared to
Autor:
Arlene Hurley, Miguel Brown, Kimberly Bogardus, Klaas E.A. Max, Kemal M. Akat, Anuoluwapo Sopeyin, Pavel Morozov, Markus F. Neurath, Thomas Tuschl, Youngmin A. Lee, Thomas G. Diacovo, Martin Borggrefe, Kai Hildner
Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. We performed conventional small-RNA-sequencing (sRNA-seq) and sRNA-seq with T4 polynucleotide kinase (PNK) end treatment of tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599ca9fcfb8bfe0a9f379d49dbbb70b3
https://europepmc.org/articles/PMC6538341/
https://europepmc.org/articles/PMC6538341/
Autor:
Diana Vetter, Adeeb H. Rahmman, Xintong Chen, Ka Hin Lee, Scott L. Friedman, Costica Aloman, Jingjing Jiao, Maria Isabel Fiel, Miriam Merad, Tatiana de Paula, David Sastre, Youngmin A. Lee, Yujin Hoshida, Meena B. Bansal, Kensuke Kojima, Kohtaro Ooka, Holger Fey
Publikováno v:
Journal of Hepatology. 65:344-353
Background & Aims Interleukin-15 (IL-15) and its high affinity receptor interleukin-15 receptor alpha (IL-15Rα) are widely expressed in immune cells and hepatic resident cells. IL-15 signaling has important functions in homeostasis of natural killer