Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Younglang Lee"'
Autor:
Younglang Lee, Alex W. Wessel, Jiazhi Xu, Julia G. Reinke, Eries Lee, Somin M. Kim, Amy P. Hsu, Jevgenia Zilberman-Rudenko, Sha Cao, Clinton Enos, Stephen R. Brooks, Zuoming Deng, Bin Lin, Adriana A. de Jesus, Daniel N. Hupalo, Daniela G.P. Piotto, Maria T. Terreri, Victoria R. Dimitriades, Clifton L. Dalgard, Steven M. Holland, Raphaela Goldbach-Mansky, Richard M. Siegel, Eric P. Hanson
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Host defense and inflammation are regulated by the NF-κB essential modulator (NEMO), a scaffolding protein with a broad immune cell and tissue expression profile. Hypomorphic mutations in inhibitor of NF-κB kinase regulatory subunit gamma (IKBKG) e
Externí odkaz:
https://doaj.org/article/d9641e906dc34284b7685c0423b10cf5
Autor:
Seung-Min Lee, Seol Hee Lee, Youngae Jung, Younglang Lee, Jong Hyun Yoon, Jeong Yi Choi, Chae Young Hwang, Young Hoon Son, Sung Sup Park, Geum-Sook Hwang, Kwang-Pyo Lee, Ki-Sun Kwon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Ageing leads to a loss of muscle mass and strength, called sarcopenia. Here, the authors show that fatty acid binding protein 3 (FABP3), a lipid chaperone, drives age-dependent lipidome remodeling in skeletal muscle and deteriorates muscle mass and c
Externí odkaz:
https://doaj.org/article/fd99792e3593409b8c42a763dceb5467
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63255 (2013)
The innate immune response is a host defense mechanism against infection by viruses and bacteria. Type I interferons (IFNα/β) play a crucial role in innate immunity. If not tightly regulated under normal conditions and during immune responses, IFN
Externí odkaz:
https://doaj.org/article/087da246995e4e95a0d861b73f8e0754
Autor:
Jeong Yi Choi, Ju Yeon Kwak, Yong Ryoul Yang, Ki-Sun Kwon, Jae Won Yang, Seung Min Lee, Younglang Lee, Kwang-Pyo Lee, Jong Hyeon Yoon, Min Ju Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 586:157-162
Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We established an atrogin-1/MAFbx promoter assay to find drug candidates that inhibit myotube atrophy. Alverine citr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fab17d910b8072ae3840c2800b5de6b
https://doi.org/10.1016/j.bbrc.2021.11.076
https://doi.org/10.1016/j.bbrc.2021.11.076
Autor:
Younglang Lee, Jeong Yi Choi, Sung Sup Park, Seol Hee Lee, Youngae Jung, Jong Hyun Yoon, Ki-Sun Kwon, Chae Young Hwang, Seung Min Lee, Young Hoon Son, Kwang-Pyo Lee, Geum-Sook Hwang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Sarcopenia is characterized by decreased skeletal muscle mass and function with age. Aged muscles have altered lipid compositions; however, the role and regulation of lipids are unknown. Here we report that FABP3 is upregulated in aged skeletal muscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f583bcdff99a3b54f6943b0931b29e
https://doaj.org/article/fd99792e3593409b8c42a763dceb5467
https://doaj.org/article/fd99792e3593409b8c42a763dceb5467
Autor:
Jevgenia Zilberman-Rudenko, Martin Pelletier, Yongquan Luo, Wanxia Li Tsai, Linda Monaco Shawver, Jordan S. Orange, Younglang Lee, Eric P. Hanson, Laurence E. Cheng, Alex W. Wessel, Spiridon Vonortas, Jonathan D. Ashwell, Richard M. Siegel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(6)
Receptor-induced NF-κB activation is controlled by NEMO, the NF-κB essential modulator. Hypomorphic NEMO mutations result in X-linked ectodermal dysplasia with anhidrosis and immunodeficiency, also referred to as NEMO syndrome. Here we describe a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb74681400126bedb7e7fe2ae5397dc
https://pubmed.ncbi.nlm.nih.gov/26865109
https://pubmed.ncbi.nlm.nih.gov/26865109
Autor:
Younglang Lee, Eries Lee, Jevgenia Zilberman-Rudenko, Yong Chen, Marjan Gucek, Richard M. Siegel, Eric Paul Hanson
Publikováno v:
The Journal of Immunology. 198:67.23-67.23
Activation of the NF-κB family of transcription factors is related to diverse biological processes, such as development, immune responses, and inflammation. As a result, mutations affecting the NF-κB signaling pathway cause syndromes characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1edbe53ac28e8e1fbc9e525d605d6425
https://doi.org/10.4049/jimmunol.198.supp.67.23
https://doi.org/10.4049/jimmunol.198.supp.67.23
Autor:
Chae Young Hwang, Kwan-Hee You, Byeongwoon Song, Jin-Soo Maeng, Keun Woo Lee, Yeung Sook Ryu, Ki-Sun Kwon, Jeong Hoon Kim, Younglang Lee, Yeon-Soo Seo
Publikováno v:
The Journal of biological chemistry. 286(29)
TRIM32, which belongs to the tripartite motif (TRIM) protein family, has the RING finger, B-box, and coiled-coil domain structures common to this protein family, along with an additional NHL domain at the C terminus. TRIM32 reportedly functions as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beec41a18ef35a29913645005fb77093
https://pubmed.ncbi.nlm.nih.gov/21628460
https://pubmed.ncbi.nlm.nih.gov/21628460
Autor:
Moonkyoung Um, Devi Rajan, Byeongwoon Song, Chae Young Hwang, Ki-Sun Kwon, Susan Kim, Younglang Lee, Jens M. Holl
Tripartite motif (TRIM) protein TRIM5alpha has been shown to restrict human immunodeficiency virus, type 1 infection in Old World monkey cells at the early post-entry step by poorly understood mechanisms. Currently, the physiological function of TRIM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfa3c65d64bda4a155da4b74652df4f
https://europepmc.org/articles/PMC2844226/
https://europepmc.org/articles/PMC2844226/
Autor:
Zilberman-Rudenko, Jevgenia, Shawver, Linda Monaco, Wessel, Alex W., Yongquan Luo, Pelletier, Martin, Wanxia Li Tsai, Younglang Lee, Vonortas, Spiridon, Cheng, Laurence, Ashwell, Jonathan D., Orange, Jordan S., Siegel, Richard M., Hanson, Eric P.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/9/2016, Vol. 113 Issue 6, p1612-1617, 6p