Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Younghwa Shin"'
Autor:
Elizabeth A. Pearsall, Rui Cheng, Kelu Zhou, Yusuke Takahashi, H. Greg Matlock, Shraddha S. Vadvalkar, Younghwa Shin, Thomas W. Fredrick, Marin L. Gantner, Steven Meng, Zhongjie Fu, Yan Gong, Michael Kinter, Kenneth M. Humphries, Luke I. Szweda, Lois E. H. Smith, Jian-xing Ma
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-14 (2017)
Abstract Background Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal homeostasis is unknown. Retinal photoreceptors are the highest energy-consum
Externí odkaz:
https://doaj.org/article/737e5444751644bb9043deb84110c20b
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(11)
Significance In humans, genetic mutations in the retinal pigment epithelium (RPE) 65 are associated with blinding diseases, for which there is no effective therapy alleviating progressive retinal degeneration in affected patients. Our findings uncove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650c1ece873353c3be731440932af314
https://pubmed.ncbi.nlm.nih.gov/35271391
https://pubmed.ncbi.nlm.nih.gov/35271391
Autor:
Yalin Wu, Fangfang Qiu, Xiang Ma, Kelu Zhou, Qing Song, Jianglei Chen, Jian Xing Ma, Younghwa Shin, Wentao Liang, Wenjing Wu, Qian Chen
Publikováno v:
Clinical Science. 134:1613-1629
Purpose: Elevated blood levels of C-reactive protein (CRP) are associated with both type 1 and type 2 diabetes and diabetic complications, such as diabetic retinopathy (DR). However, its pathogenic role in DR remains unknown. The present study aims t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d31f7154c1d15e6bfaf4d2f191d6bd
https://doi.org/10.1042/cs20200085
https://doi.org/10.1042/cs20200085
Autor:
Siribhinya Benyajati, Marcus Dehdarani, Wenjing Wu, Younghwa Shin, Yusuke Takahashi, Wentao Liang, Xiang Ma, Jianglei Chen, Jian Xing Ma
Publikováno v:
The FASEB Journal. 35
Subretinal fibrosis is a key pathological feature in neovascular age-related macular degeneration (nAMD). Previously, we identified soluble very low-density lipoprotein receptor (sVLDLR) as an endogenous Wnt signaling inhibitor. This study investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b67599ce3278da0bfa3b5fca846070d
https://doi.org/10.1096/fj.202101334r
https://doi.org/10.1096/fj.202101334r
Autor:
Qian Chen, Younghwa Shin, Fangfang Qiu, Rui Cheng, Kelu Zhou, Andrew R. Mendelson, Jian Xing Ma, Danyang Chen, James W. Larrick
Publikováno v:
Microvascular Research. 119:29-37
Purpose Our previous study demonstrated that Mab2F1, a murine monoclonal antibody blocking the Wnt/β-catenin signaling pathway, has beneficial effects on experimental diabetic retinopathy and choroidal neovascularization (NV). The aforementioned ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4e24cd02f26aa6d2e5e04864120ce1
https://doi.org/10.1016/j.mvr.2018.03.011
https://doi.org/10.1016/j.mvr.2018.03.011
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2717-2722
Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. Herein we report initial structure–activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5daa17f55943f23014653ef5b450141
https://doi.org/10.1016/j.bmcl.2018.03.010
https://doi.org/10.1016/j.bmcl.2018.03.010
Publikováno v:
The American Journal of Pathology. 187(3):517-527
RPE65 is an indispensable component of the retinoid visual cycle in vertebrates, through which the visual chromophore 11-cis-retinal (11-cis-RAL) is generated to maintain normal vision. Various blinding conditions in humans, such as Leber congenital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15235ce660b5b44fa8b8aec48ee68fa1
Publikováno v:
Korean Journal of Family Social Work. :265-297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::198c00748af29632b8fa482d3671e24d
https://doi.org/10.16975/kjfsw.2017..55.009
https://doi.org/10.16975/kjfsw.2017..55.009
Autor:
Rafal Farjo, Laura Otalora, Aaron J Dockins, Krysten M. Farjo, Eric D. Phelps, Jian Xing Ma, Younghwa Shin, Gennadiy Moiseyev, Michael J. Balangue, Shelley Kane, Mei Du
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Transgenic mice overexpressing serum retinol-binding protein (RBP4-Tg) develop progressive retinal degeneration, characterized by microglia activation, yet the precise mechanisms underlying retinal degeneration are unclear. Previous studies s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45da8a1fa31fb18e53d4db55df5f7ea1
http://europepmc.org/articles/PMC5560100
http://europepmc.org/articles/PMC5560100
Publikováno v:
The American Journal of Pathology
Diabetic retinopathy is a common complication of diabetes mellitus. Diabetic patients experience functional deficits in dark adaptation, contrast sensitivity, and color perception before microvascular pathologies become apparent. Herein, we evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40c85c9920fd933bc9b8071e9cd3ad8
http://europepmc.org/articles/PMC5809515
http://europepmc.org/articles/PMC5809515