Výsledky vyhledávání - "Younghwa, Na"

Akademický článek

Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction

Autor: Soo-Yeon Hwang, Kyung-Hwa Jeon, Hwa-Jong Lee, Inhye Moon, Sehyun Jung, Seul-Ah Kim, Hyunji Jo, Seojeong Park, Misun Ahn, Soo-Yeon Kwak, Younghwa Na, Youngjoo Kwon

Publikováno v: eLife, Vol 13 (2024)

HER2 overexpression significantly contributes to the aggressive nature and recurrent patterns observed in various solid tumors, notably gastric cancers. Trastuzumab, HER2-targeting monoclonal antibody drug, has shown considerable clinical success; ho

Externí odkaz: https://doaj.org/article/299cfce3e3f844a5afe06b7ebbe171b3

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Akademický článek

Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers

Autor: Soo-Yeon Hwang, Seojeong Park, Hyunji Jo, Seung Hee Seo, Kyung-Hwa Jeon, Seojeong Kim, Ah-Reum Jung, Chanju Song, Misun Ahn, Soo Yeon Kwak, Hwa-Jong Lee, Motonari Uesugi, Younghwa Na, Youngjoo Kwon

Publikováno v: Journal of Advanced Research, Vol 47, Iss , Pp 173-187 (2023)

Introduction: HER2 overexpression induces cancer aggression and frequent recurrences in many solid tumors. Because HER2 overproduction is generally followed by gene amplification, inhibition of protein–protein interaction (PPI) between transcriptio

Externí odkaz: https://doaj.org/article/c514c7b5d10c489d80d09349a306cdd7

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Akademický článek

The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis

Autor: Seulgi Jeon, Hee Jin, Jin-Mo Kim, Youmin Hur, Eun Joo Song, Yoon-Jin Lee, Younghwa Na, Jaeho Cho, Yun-Sil Lee

Publikováno v: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-15 (2023)

Abstract Background Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well elucidated. Methods We hav

Externí odkaz: https://doaj.org/article/d0a375e845924f3cbfe10b963f6260a5

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Akademický článek

Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis

Autor: Young Jo Yoo, Seulgi Jeon, Hee Jin, Hee Yeon Won, Mi Gyeong Jeong, Yeseul Cho, Eun Sook Hwang, Younghwa Na, Jaeho Cho, Yun-Sil Lee

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Background: Pulmonary fibrosis (PF) is a progressive lung disease characterized by fibroblast accumulation and collagen deposition, resulting in lung scarring and impaired gas exchange. Current treatments for idiopathic pulmonary fibrosis (IPF) have

Externí odkaz: https://doaj.org/article/d204f7a99021418ca804732268592569

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Akademický článek

Synthetic TGF-β Signaling Agonist-Treated Dendritic Cells Induce Tolerogenicity and Antirheumatic Effects

Autor: Ji-Soo Oh, Sung-Uk Hwang, Kyung-Eun Noh, Jun-Ho Lee, So-Yeon Choi, Ji-Hee Nam, Min-Seon Song, Nam-Chul Jung, Jie-Young Song, Han Geuk Seo, Younghwa Na, Dae-Seog Lim

Publikováno v: Current Issues in Molecular Biology, Vol 44, Iss 9, Pp 3809-3821 (2022)

The newly synthesized compound TGF-β signaling agonist (T74) is a small molecule associated with the TGF-β receptor signaling pathway. Tolerogenic dendritic cells (tDCs) have been used to examine immunosuppressive and anti-inflammatory effects in m

Externí odkaz: https://doaj.org/article/4bcc0dc6c6a946c0995802e69def93d3

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Akademický článek

Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers

Autor: Hawon Yoo, Seul-Ki Choi, Jaeok Lee, So Hyeon Park, You Na Park, Soo-Yeon Hwang, Jae-Ho Shin, Younghwa Na, Youngjoo Kwon, Hwa Jeong Lee, Yun-Sil Lee

Publikováno v: Pharmaceutics, Vol 13, Iss 5, p 630 (2021)

Relationships between heat shock protein 27 (HSP27) and cancer aggressiveness, metastasis, drug resistance, and poor patient outcomes in various cancer types including non-small cell lung cancer (NSCLC) were reported, and inhibition of HSP27 expressi

Externí odkaz: https://doaj.org/article/3b6e8d0030624230831eee3ffb92d114

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Akademický článek

Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents

Autor: Jaeok Lee, Jiyeon Kang, Na-Yun Kwon, Aneesh Sivaraman, Ravi Naik, So-Young Jin, A. Reum Oh, Jae-Ho Shin, Younghwa Na, Kyeong Lee, Hwa-Jeong Lee

Publikováno v: Pharmaceutics, Vol 13, Iss 4, p 559 (2021)

P-glycoprotein (P-gp) inhibition has been studied to overcome multidrug resistance in cancer chemotherapy but failed in clinical trials due to low/toxic effects. Recently, a dual modulation of transporters and natural derivatives have been examined t

Externí odkaz: https://doaj.org/article/3038fe5315bd40aab778612323b0af6b

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