Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Younghee Ju"'
Autor:
Geurim Son, Yongwoo Na, Yongsung Kim, Ji-Hoon Son, Gregory D. Clemenson, Simon T. Schafer, Jong-Yeon Yoo, Sarah L. Parylak, Apua Paquola, Hyunsu Do, Dayeon Kim, Insook Ahn, Mingyu Ju, Chanhee S. Kang, Younghee Ju, Eunji Jung, Aidan H. McDonald, Youngjin Park, Gilhyun Kim, Se-Bum Paik, Junho Hur, Joon Kim, Yong-Mahn Han, Seung-Hee Lee, Fred H. Gage, Jong-Seo Kim, Jinju Han
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Metabolic dysregulation of neurons is associated with diverse human brain disorders. Metabolic reprogramming occurs during neuronal differentiation, but it is not fully understood which molecules regulate metabolic changes at the early stage
Externí odkaz:
https://doaj.org/article/117d78122c2b4844ba1c7183de9b7ddf
Autor:
Younghee Ju, Jun Sung Park, Daejeong Kim, Bumsoo Kim, Jeong Ho Lee, Yoonkey Nam, Han-Wook Yoo, Beom Hee Lee, Yong-Mahn Han
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-19 (2020)
Abstract Background Noonan syndrome (NS) is a developmental disorder caused by mutations of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2). Although NS patients have diverse neurological manifestations, the mechanisms underlyi
Externí odkaz:
https://doaj.org/article/3187e35196aa43978ab712b6110b7d33
Autor:
Younghee Ju, Jun Sung Park, Daejeong Kim, Bumsoo Kim, Jeong Ho Lee, Yoonkey Nam, Han-Wook Yoo, Beom Hee Lee, Yong-Mahn Han
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/e521a4cc38c54a57966878d5dd5b73fe
Autor:
Bumsoo Kim, Yongjun Koh, Hyunsu Do, Younghee Ju, Jong Bin Choi, Gahyang Cho, Han-Wook Yoo, Beom Hee Lee, Jinju Han, Jong-Eun Park, Yong-Mahn Han
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13861
Noonan syndrome (NS) is a genetic disorder mainly caused by gain-of-function mutations in Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2). Although diverse neurological manifestations are commonly diagnosed in NS patients, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ad440fd3baae53a1440cb9c431d4d2
https://doi.org/10.3390/ijms232213861
https://doi.org/10.3390/ijms232213861
Autor:
Eungu Kang, In Hee Choi, Yong Seok Lee, Han Wook Yoo, Beom Hee Lee, Young Hoon Sung, In Jeoung Baek, Minji Kang, Woo-Chan Son, Eul Ju Seo, Dong Cheol Woo, Woo Hyun Shim, Younghee Ju, Yong-Mahn Han, Sang Joon Lee
Publikováno v:
Journal of medical genetics. 58(11)
BackgroundARID2 belongs to the Switch/sucrose non-fermenting complex, in which the genetic defects have been found in patients with dysmorphism, short stature and intellectual disability (ID). As the phenotypes of patients with ARID2 mutations partia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cf5e9c90ce8553b252c88316750040
https://pubmed.ncbi.nlm.nih.gov/33051312
https://pubmed.ncbi.nlm.nih.gov/33051312
Autor:
Younghee Ju, Park, Jun Sung, Daejeong Kim, Bumsoo Kim, Lee, Jeong Ho, Yoonkey Nam, Han-Wook Yoo, Lee, Beom Hee, Han, Yong-Mahn
Additional file 2: Figure S1. Characterization of NS-iPSCs. (A) Expression of pluripotency markers in the NS-iPSCs. Similar to the WT-iPSCs, the NS iPSCs expressed various pluripotency markers, such as OCT4, SOX2, NANOG, TRA-1-60, and TRA-1-81. Scale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea263b42d3329688c3abae5245dce32
Autor:
Younghee Ju, Park, Jun Sung, Daejeong Kim, Bumsoo Kim, Lee, Jeong Ho, Yoonkey Nam, Han-Wook Yoo, Lee, Beom Hee, Han, Yong-Mahn
Additional file 1: Table S1. Primersa used in this study Table S2. Primary antibodies used for the immunofluorescence and western blotting assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884eb1d5d531eb016079a6428b5ed38e
Autor:
Younghee Ju, Park, Jun Sung, Daejeong Kim, Bumsoo Kim, Lee, Jeong Ho, Yoonkey Nam, Han-Wook Yoo, Lee, Beom Hee, Han, Yong-Mahn
Additional file 5: Figure S4. Treatments of NS-iPSCs with diverse chemicals during EB formation. (A) Effects of BMP inhibitor and TGF-β inhibitor on EB formation in NS-iPSCs. Treatment of either BMP inhibitor or TGF-β inhibitor alone was not effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a47c4a9b98c2df57cc67a56a11e339
Autor:
Younghee Ju, Park, Jun Sung, Daejeong Kim, Bumsoo Kim, Lee, Jeong Ho, Yoonkey Nam, Han-Wook Yoo, Lee, Beom Hee, Han, Yong-Mahn
Additional file 9: Figure S8. Spontaneous neural activities of cerebral organoids at 55 day of culture (A) Raster plots for extracellular spikes measured in cerebral organoids at 55 day of culture. (B-C) Number of spikes and spike frequency in cerebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c20c91cd3c0cf8d8c244f4719969efa
Autor:
Younghee Ju, Park, Jun Sung, Daejeong Kim, Bumsoo Kim, Lee, Jeong Ho, Yoonkey Nam, Han-Wook Yoo, Lee, Beom Hee, Han, Yong-Mahn
Additional file 8: Figure S7. Time-course extracellular neural activities of NS-neural cells. (A) Monitoring of number of spontaneous extracellular spikes during neural differentiation. In WT- and NS-neural cells, recording of extracellular neural ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1827776daac53156b42f50f63bda825d