Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Younger W-Y Yu"'
Autor:
Ying-Jay Liou, Chien-Hsiun Chen, Chih-Ya Cheng, Shiow-Yi Chen, Tai-Jui Chen, Younger W-Y Yu, Fang-Shin Nian, Shih-Jen Tsai, Chen-Jee Hong
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e32984 (2012)
OBJECTIVES: The forced swim test (FST) is a commonly used model to predict antidepressant efficacy. Uncovering the genetic basis of the model may unravel the mechanism of antidepressant treatment. METHODS: FVB/NJ (FVB) and C57BL/6J (B6) were first id
Externí odkaz:
https://doaj.org/article/7a48a5fcc4064ba9875b8dee4e19ffc9
Autor:
Chung-Feng Kao, Po-Hsiu Kuo, Younger W.-Y. Yu, Albert C. Yang, Eugene Lin, Yu-Li Liu, Shih-Jen Tsai
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The serotonin [5-hydroxytryptamine (5-HT)] system has been implicated in the pathogenesis of major depressive disorder (MDD). Among the 5-HT receptor subtypes, 5-HT2 is one of the major pharmacological therapeutic targets for MDD. There have been inc
Externí odkaz:
https://doaj.org/article/5189aa30120543c6802f25bb5da36a4b
Autor:
Chung-Feng Kao, Yu-Li Liu, Younger W.-Y. Yu, Albert C. Yang, Eugene Lin, Po-Hsiu Kuo, Shih-Jen Tsai
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract It is well established that brain-derived neurotrophic factor (BDNF) signaling pathway plays a key role in the pathophysiology of major depressive disorder (MDD) and in therapeutic mechanisms of antidepressants. We aim to identify genetic va
Externí odkaz:
https://doaj.org/article/99bed60d7b9f4c5dbed09c6b9762adde
Publikováno v:
Pharmaceuticals, Vol 13, Iss 305, p 305 (2020)
Pharmaceuticals
Volume 13
Issue 10
Pharmaceuticals
Volume 13
Issue 10
In the wake of recent advances in machine learning research, the study of pharmacogenomics using predictive algorithms serves as a new paradigmatic application. In this work, our goal was to explore an ensemble machine learning approach which aims to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ae192bab240db9cfe231939df472e
https://www.mdpi.com/1424-8247/13/10/305
https://www.mdpi.com/1424-8247/13/10/305
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 9 (2018)
Frontiers in Psychiatry, Vol 9 (2018)
In the wake of recent advances in scientific research, personalized medicine using deep learning techniques represents a new paradigm. In this work, our goal was to establish deep learning models which distinguish responders from non-responders, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab44835e1a305a51ced27c4e42ffbb8
https://doi.org/10.3389/fpsyt.2018.00290
https://doi.org/10.3389/fpsyt.2018.00290
Autor:
Po-Hsiu Kuo, Yu-Li Liu, Albert C. Yang, Younger W.-Y. Yu, Chung Feng Kao, Shih-Jen Tsai, Eugene Lin
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
It is well established that brain-derived neurotrophic factor (BDNF) signaling pathway plays a key role in the pathophysiology of major depressive disorder (MDD) and in therapeutic mechanisms of antidepressants. We aim to identify genetic vairiants r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9ba14726d878209d737e842b51f195
https://doi.org/10.1038/s41598-018-25529-y
https://doi.org/10.1038/s41598-018-25529-y
Publikováno v:
Current Pharmacogenomics and Personalized Medicine. 11:316-323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced6caa008d54e3666b3eddaa7831c09
https://doi.org/10.2174/1875692111666131211235804
https://doi.org/10.2174/1875692111666131211235804
Publikováno v:
Brain Topography. 25:431-442
The epsilon4 allele of the Apolipoprotein E (ApoE) gene has been linked to various neurological conditions and the aging process in the elderly. However, evidence has suggested that the influence of ApoE epsilon4 may commence in early life. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf00eaf2c7d12e35240f6c7c6fbb8dc
https://doi.org/10.1007/s10548-012-0229-y
https://doi.org/10.1007/s10548-012-0229-y
Publikováno v:
The Open Neuroimaging Journal
The polymorphism of variable number of tandem repeat (VNTR) in dopamine receptor D4 (DRD4) gene exon III has been linked to various neuro-psychiatric conditions with disinhibition/impulsivity as one of the core features. This study examined the modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631eec5435708aa4fcf996cf6aaec5bb
http://europepmc.org/articles/PMC3308261
http://europepmc.org/articles/PMC3308261
Publikováno v:
Intelligence. 40:38-48
General intelligence, the g factor, is a major issue in psychology and neuroscience. However, the neural mechanism of the g factor is still not clear. It is suggested that the g factor should be non-modular (a property across the brain) and show good
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::111364708f8d23e7d4b0b008a6b3558d
https://doi.org/10.1016/j.intell.2011.11.001
https://doi.org/10.1016/j.intell.2011.11.001