Zobrazeno 1 - 10
of 48
pro vyhledávání: '"YoungJun Ju"'
Autor:
Zhe Jiang, YoungJun Ju, Amjad Ali, Philip E. D. Chung, Patryk Skowron, Dong-Yu Wang, Mariusz Shrestha, Huiqin Li, Jeff C. Liu, Ioulia Vorobieva, Ronak Ghanbari-Azarnier, Ethel Mwewa, Marianne Koritzinsky, Yaacov Ben-David, James R. Woodgett, Charles M. Perou, Adam Dupuy, Gary D. Bader, Sean E. Egan, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive anima
Externí odkaz:
https://doaj.org/article/141fc3ada18346a59e6af3fd9ea5bbbb
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-27 (2021)
Abstract Mild traumatic brain injury (mTBI) results in broad neurological symptoms and an increased risk of being diagnosed with a neurodegenerative disease later in life. While the immediate oxidative stress response and post-mortem pathology of the
Externí odkaz:
https://doaj.org/article/d51674bb3f7b4b69bb65ff46e0d41cc2
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The eukaryotic elongation factor-2 kinase, eEF2K, which restricts protein translation elongation, has been identified as a potential therapeutic target for diverse types of malignancies including triple negative breast cancer (TNBC). However
Externí odkaz:
https://doaj.org/article/28af1161c814459a8eb7f79bbbb8d004
Autor:
Jeff C. Liu, Letizia Granieri, Mariusz Shrestha, Dong-Yu Wang, Ioulia Vorobieva, Elizabeth A. Rubie, Rob Jones, YoungJun Ju, Giovanna Pellecchia, Zhe Jiang, Carlo A. Palmerini, Yaacov Ben-David, Sean E. Egan, James R. Woodgett, Gary D. Bader, Alessandro Datti, Eldad Zacksenhaus
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 112-126 (2018)
Summary: CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative breast cancer (TNBC), RB1 and PTEN are frequently inact
Externí odkaz:
https://doaj.org/article/2f8dda134cd247b39c4432a3f20e70bd
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 27-34 (2016)
The importance of H2S in biology and medicine has been widely recognized in recent years, and protein S-sulfhydration is proposed to mediate the direct actions of H2S bioactivity in the body. Thioredoxin 1 (Trx1) is an important reducing enzyme that
Externí odkaz:
https://doaj.org/article/fb458ec69a054f30b9b7f0a4d4eb02e5
Autor:
Eldad Zacksenhaus, Jeff C. Liu, Letizia Granieri, Ioulia Vorobieva, Dong-Yu Wang, Ronak Ghanbari-Azarnier, Huiqin Li, Amjad Ali, Philip E.D. Chung, YoungJun Ju, Zhe Jiang, Mariusz Shrestha
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppress tumor growth. We
Externí odkaz:
https://doaj.org/article/b800192a59594419840d71c3a1e6fd55
Publikováno v:
Molecules, Vol 22, Iss 8, p 1334 (2017)
Protein S-sulfhydration is a newly discovered post-translational modification of specific cysteine residue(s) in target proteins, which is involved in a broad range of cellular functions and metabolic pathways. By changing local conformation and the
Externí odkaz:
https://doaj.org/article/596046e20897498ba4c8dd63514352d0
Autor:
Joongbok Ok, Jusang Yang, Hansol Kim, Seok Joon Kwon, Sung Gil Hong, Youngjun Ju, Jonathan S. Dordick, Kyung Min Yeon, Jungbae Kim
Publikováno v:
Journal of CO2 Utilization. 38:291-298
Carbonic anhydrases (CAs) are enzymes that can function at physiologic interfaces and catalyze the interfacial conversion of carbon dioxide (CO2) into bicarbonate (HCO3−) with an extraordinarily high catalytic efficiency. Even though CAs have poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70dff1f4fc9666e296e67e5e2c7309fd
https://doi.org/10.1016/j.jcou.2020.02.005
https://doi.org/10.1016/j.jcou.2020.02.005
Autor:
Zhe Jiang, Huiqin Li, Stephanie A Schroer, Veronique Voisin, YoungJun Ju, Marek Pacal, Natalie Erdmann, Wei Shi, Philip E D Chung, Tao Deng, Nien‐Jung Chen, Giovanni Ciavarra, Alessandro Datti, Tak W Mak, Lea Harrington, Frederick A Dick, Gary D Bader, Rod Bremner, Minna Woo, Eldad Zacksenhaus
Publikováno v:
Paediatrics Publications
Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb∆K4 and Rb∆K7 knock-in mice, in which either four or all seven phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae2e6214979e7db704b97c706134c0c
https://ir.lib.uwo.ca/paedpub/1150
https://ir.lib.uwo.ca/paedpub/1150
Publikováno v:
Biosensors and Bioelectronics. 132:279-285
Highly sensitive phenol biosensor was developed by using well-dispersed carbon nanotubes (CNTs) in enzyme solution and adding CNTs in enzyme electrodes. First, the intact CNTs were dispersed in aqueous tyrosinase (TYR) solution, and TYR molecules wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d6d29f9b0436f04c784e16c77a319d
https://doi.org/10.1016/j.bios.2019.03.008
https://doi.org/10.1016/j.bios.2019.03.008