Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase.

Autor: Young-Sik Sohn, Seong-Gyu Lee, Kwang-Hoon Lee, Bonsu Ku, Ho-Chul Shin, Sun-Shin Cha, Yeon-Gil Kim, Hyun Sook Lee, Sung-Gyun Kang, Byung-Ha Oh

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167549 (2016)

A hypothetical protein TON_0340 of a Thermococcus species is a protein conserved in a variety of organisms including human. Herein, we present four different crystal structures of TON_0340, leading to the identification of an active-site cavity harbo

Externí odkaz: https://doaj.org/article/ddf57cd3c1714384a0f75a7e82164efe

Selective probes and antagonists for G protein-coupled receptor LPAR1

Autor: Young-sik Sohn, Sangbae Lee, Eun Sung A. Cho

Publikováno v: Biophysical Journal. 122:134a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7aa42819cdadd0bc3a518bbf55da476
https://doi.org/10.1016/j.bpj.2022.11.889

Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory

Autor: Young-sik Sohn, Keun Woo Lee, C. Meganathan, Sundaraganesan Namadevan, Sugunadevi Sakkiah

Publikováno v: International Journal of Molecular Sciences, Vol 13, Iss 4, Pp 5138-5162 (2012)
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(13): 4
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 13; Issue 4; Pages: 5138-5162

11 beta-Hydroxysteroid dehydrogenase type1 (11 beta HSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11 beta HSD1 has been thought of as an effective app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d3c1dff7e837c8ab0b1f93847581b0
http://www.mdpi.com/1422-0067/13/4/5138

Multi-conformation dynamic pharmacophore modeling of the peroxisome proliferator-activated receptor γ for the discovery of novel agonists

Autor: Songmi Kim, Young-sik Sohn, Yuno Lee, Keun Woo Lee, Yongseong Kim, Sundarapandian Thangapandian, Jung-Keun Suh, Chanin Park, Hyong-Ha Kim

Publikováno v: Journal of molecular graphicsmodelling. 46

Activation of the peroxisome proliferator-activated receptor γ (PPARγ) is important for the treatment of type 2 diabetes and obesity through the regulation of glucose metabolism and fatty acid accumulation. Hence, the discovery of novel PPARγ agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a86dbcfffdcb251f4859aa0772e7daa
https://pubmed.ncbi.nlm.nih.gov/24104184

Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22

Autor: Jianning Ge, Byung-Ha Oh, Young-sik Sohn, Jae U. Jung, Bok Luel Lee, Wei Sun Park, Won Do Heo, Daniel J. Rigden, Ho-Chul Shin, Chan-Hee Kim

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0118683 (2015)

Legionella pneumophila, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery. Some of these proteins have been shown to manipulate or subvert cellular processes during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b936b9feb9b2ef3c63eb0b729335917
https://doi.org/10.1371/journal.pone.0118683