Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.

Autor: Shvartsbart A; Prelude Therapeutics, Wilmington, Delaware 19803, United States., Roach JJ; Proteovant Therapeutics, King of Prussia, Pennsylvania 19406, United States., Witten MR; Incyte Corporation, Wilmington, Delaware 19803, United States., Koblish H; Ikena Oncology, Boston, Massachusetts 02210, United States., Harris JJ; Incyte Corporation, Wilmington, Delaware 19803, United States., Covington M; Incyte Corporation, Wilmington, Delaware 19803, United States., Hess R; Incyte Corporation, Wilmington, Delaware 19803, United States., Lin L; WuXi AppTec, Philadelphia, Pennsylvania 19112, United States., Frascella M; Incyte Corporation, Wilmington, Delaware 19803, United States., Truong L; Incyte Corporation, Wilmington, Delaware 19803, United States., Leffet L; Incyte Corporation, Wilmington, Delaware 19803, United States., Conlen P; Incyte Corporation, Wilmington, Delaware 19803, United States., Beshad E; Proteovant Therapeutics, King of Prussia, Pennsylvania 19406, United States., Klabe R; Incyte Corporation, Wilmington, Delaware 19803, United States., Katiyar K; Incyte Corporation, Wilmington, Delaware 19803, United States., Kaldon L; Incyte Corporation, Wilmington, Delaware 19803, United States., Young-Sciame R; Incyte Corporation, Wilmington, Delaware 19803, United States., He X; Incyte Corporation, Wilmington, Delaware 19803, United States., Petusky S; Incyte Corporation, Wilmington, Delaware 19803, United States., Chen KJ; Incyte Corporation, Wilmington, Delaware 19803, United States., Horsey A; Incyte Corporation, Wilmington, Delaware 19803, United States., Lei HT; Incyte Corporation, Wilmington, Delaware 19803, United States., Epling LB; Incyte Corporation, Wilmington, Delaware 19803, United States., Deller MC; Incyte Corporation, Wilmington, Delaware 19803, United States., Vechorkin O; Incyte Corporation, Wilmington, Delaware 19803, United States., Yao W; Synnovation Therapeutics, Wilmington, Delaware 19803, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Nov 24; Vol. 65 (22), pp. 15433-15442. Date of Electronic Publication: 2022 Nov 10.

Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.

Autor: Boer J; Incyte Corporation, Wilmington, Delaware jboer@incyte.com., Young-Sciame R; Incyte Corporation, Wilmington, Delaware., Lee F; Incyte Corporation, Wilmington, Delaware., Bowman KJ; Incyte Corporation, Wilmington, Delaware., Yang X; Incyte Corporation, Wilmington, Delaware., Shi JG; Incyte Corporation, Wilmington, Delaware., Nedza FM; Incyte Corporation, Wilmington, Delaware., Frietze W; Incyte Corporation, Wilmington, Delaware., Galya L; Incyte Corporation, Wilmington, Delaware., Combs AP; Incyte Corporation, Wilmington, Delaware., Yeleswaram S; Incyte Corporation, Wilmington, Delaware., Diamond S; Incyte Corporation, Wilmington, Delaware.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Oct; Vol. 44 (10), pp. 1668-74. Date of Electronic Publication: 2016 Jul 25.

Liquid Chromatography−Electrospray Ionization Mass Spectrometric Detection of an Ethenodeoxyguanosine Adduct and Its Hemiaminal Precursors in DNA Reacted with α-Acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal

Autor: Liu, Z., Young-Sciame, R., Hecht, S. S.

Publikováno v: Chemical Research in Toxicology; June 3, 1996, Vol. 9 Issue: 4 p774-780, 7p

Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.

Autor: Kaila N; Chemical and Screening Sciences, Cardiovascular and Metabolic Disease, Drug Safety and Metabolism, Inflammation, Wyeth Research, Cambridge, Massachusetts 02140, USA. nkaila@wyeth.com, Janz K, DeBernardo S, Bedard PW, Camphausen RT, Tam S, Tsao DH, Keith JC Jr, Nickerson-Nutter C, Shilling A, Young-Sciame R, Wang Q

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Jan 11; Vol. 50 (1), pp. 21-39.

Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.

Autor: Liu Z; American Health Foundation, Valhalla, New York 10595, USA., Young-Sciame R, Hecht SS

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 1996 Jun; Vol. 9 (4), pp. 774-80.