Bacteroides fragilisEnterotoxin Induces Human β-Defensin-2 Expression in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase/IκB Kinase/NF-κB-Dependent Pathway

Autor: Jin-Young Lee, Ju Seop Kang, Doyoung Yoo, Sunil Kim, Yu-Kyoung Oh, Jung Mogg Kim, Joo Sung Kim, Young-Mee Yoon, Young Suk Sim, Young Jeon Kim

Publikováno v: Infection and Immunity. 78:2024-2033

EnterotoxigenicBacteroides fragilis(ETBF) produces an approximately 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although spontaneous disappearance of ETBF infection is common, little information is avail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d139444848dac730d260ab530845c2c8
https://doi.org/10.1128/iai.00118-10

A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

Autor: Clive Wasserfall, Young-Mee Yoon, Benjamin G. Keselowsky, Mark A. Atkinson, Matthew R. Carstens, Jamal S. Lewis, Martha Campbell-Thompson

Publikováno v: Scientific Reports
Scientific reports, vol 5, iss 1
Yoon, YM; Lewis, JS; Carstens, MR; Campbell-Thompson, M; Wasserfall, CH; Atkinson, MA; et al.(2015). A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice. Scientific Reports, 5. doi: 10.1038/srep13155. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7t41x49b

Targeted delivery of self-antigens to the immune system in a mode that stimulates a tolerance-inducing pathway has proven difficult. To address this hurdle, we developed a vaccine based-approach comprised of two synthetic controlled-release biomateri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0dc182c22cdfa3daa05e11034ddbc8
http://europepmc.org/articles/PMC4538389

NF-kappaB Activation Pathway is Essential for the Chemokine Expression in Intestinal Epithelial Cells Stimulated with Clostridium difficile Toxin A

Autor: Y.-K. Oh, Young-Mee Yoon, Y.-J. Kim, Jeehee Youn, Jung Mogg Kim, J. Y. Lee

Publikováno v: Scandinavian Journal of Immunology. 63:453-460

Intestinal epithelial cells are known to upregulate the expression of several chemokines in response to stimulation with bacterial toxin. However, the cellular mechanisms of Clostridium difficile toxin A-induced mucosal inflammation have not yet been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9142aa5d5d8747de42ec13bec7c1cc
https://doi.org/10.1111/j.1365-3083.2006.001756.x

Opposing Role of Mitogen-activated Protein Kinase Subtypes, Erk-1/2 and p38, in the Regulation of Chondrogenesis of Mesenchymes

Autor: Yun Sil Lee, Jang-Soo Chun, Chun-Do Oh, Sung Hee Chang, Shin Sung Kang, Young-Mee Yoon, Su Jae Lee

Publikováno v: Journal of Biological Chemistry. 275:5613-5619

The present studies were performed to determine subtype-specific roles of mitogen-activated protein kinase in chondrogenesis. Erk-1/2 activities, downstream of protein kinase C, decreased as chondrogenesis proceeded, whereas p38 activities, independe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399be8a3892f27712a83887c7aa0b745
https://doi.org/10.1074/jbc.275.8.5613

WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase

Autor: Young-Mee Yoon, Sook-Jung Jeong, Kwan-Hyuck Baek, Geun-Hyoung Ha, Jang-Soo Chun, Ae-Hwa Jeon, Chang-Woo Lee, Hyun-Jin Shin, Sang-Gu Hwang

Publikováno v: FEBS letters. 575(1-3)

WD repeats are implicated in protein–protein interactions and regulate a wide variety of cellular functions, including chromatin remodeling and transcription. The WD repeats of the Bub3 and Cdc20 kinetochore proteins are important for the physical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be6a330ce8d1b383c3703445e41c408
https://pubmed.ncbi.nlm.nih.gov/15388328