Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Young-Jun Shim"'
Publikováno v:
Cells, Vol 13, Iss 11, p 891 (2024)
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of
Externí odkaz:
https://doaj.org/article/6d88eb26bd4948ef971f8340fd052cc0
Autor:
Steven Philip Grover, Tomohiro Kawano, Jun Wan, Pansakorn Tanratana, Zsofia Polai, Young Jun Shim, Omri Snir, Sigrid K. Brækkan, Sophia Dhrolia, Rohan Raj Kasthuri, Tem Bendapudi, Keith R McCrae, Alisa S. Wolberg, John-Bjarne Hansen, Henriette Farkas, Nigel Mackman
Publikováno v:
Blood.
C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a major negative regulator of several biological pathways, including the contact pathway of blood coagulation. In humans, congenital C1INH deficiency results in a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a1ba73738a91df34779771f6ff9d56
https://doi.org/10.1182/blood.2022018849
https://doi.org/10.1182/blood.2022018849
Autor:
Alvin H. Schmaier, Dana E. Angelini, Ravi Kumar Alluri, John Barnard, Suman Kundu, Keith R. McCrae, Edward P. Feener, Samantha A. Whitney, Victor Chatterjee, Alok A. Khorana, Young Jun Shim, Dewen You, Shadi Swaidani, Alona Merkulova
Publikováno v:
Blood Advances
Key Points Cleaved HK is observed in many patients with cancer, suggesting activation of the contact system.EVs from cancer cell lines or patients with cancer express polyphosphate, bind and activate FXII, and are prothrombotic.
Visual Abstract<
Visual Abstract<
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20370bd70436fc1df9423e0e59c0c7fe
http://europepmc.org/articles/PMC8759128
http://europepmc.org/articles/PMC8759128
Autor:
Young Jun Shim, Pat Rayman, Paul Pavicic, Shadi Swaidani, Alok A Khorana, Marcela Diaz-Montero, Keith R. McCrae
Publikováno v:
Blood. 140:8365-8366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d2776d349dfc5aaa795d2ce0c38d3c
https://doi.org/10.1182/blood-2022-170687
https://doi.org/10.1182/blood-2022-170687
Autor:
Young Jun Shim, Yohei Hisada, Shadi Swaidani, Paul Pavicic, Alok A Khorana, Marcela Diaz-Montero, Nigel Mackman, Keith R. McCrae
Publikováno v:
Blood. 140:8393-8394
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf13698a6e25df410d73d153e606f92a
https://doi.org/10.1182/blood-2022-171043
https://doi.org/10.1182/blood-2022-171043
Publikováno v:
Blood. 140:11208-11209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f92bedbfb541a686b4661b3cf3265b
https://doi.org/10.1182/blood-2022-170261
https://doi.org/10.1182/blood-2022-170261
Autor:
Young Jun Shim, Nina Dvorina, Raneem Khedraki, Jayeeta Dhar, William M. Baldwin, Anna Valujskikh, Robert L. Fairchild, Ran Fan
Publikováno v:
Kidney Int
Allogeneic transplants elicit dynamic T cell responses that are modulated by positive and negative co-stimulatory receptors. Understanding mechanisms that intrinsically modulate the immune responses to transplants is vital to develop rational treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3816e4bdcfcfabac74fdfa6137f7acde
https://doi.org/10.1016/j.kint.2020.03.037
https://doi.org/10.1016/j.kint.2020.03.037
Autor:
Keith R. McCrae, Aatira Vijay, Adam Mauskapf, Mohamad B Kassab, Young Jun Shim, Shadi Swaidani, Farouc A. Jaffer
Publikováno v:
Blood. 138:289-289
Background- High molecular weight Kininogen (HK) is a nonenzymatic co-factor of the contact activation system. HK binds prekallikrein (PK) and FXI to surfaces in proximity to FXII, amplifying PK activation by FXIIa and the reciprocal activation of FX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aacafedf6a5bed6755a3762a13745b91
https://doi.org/10.1182/blood-2021-153316
https://doi.org/10.1182/blood-2021-153316
Autor:
C. Marcela Diaz-Montero, Keith R. McCrae, Shadi Swaidani, Paul G. Pavicic, Patricia Rayman, Alok A. Khorana, Young Jun Shim
Publikováno v:
Blood. 138:779-779
Abstract Background: Venous thromboembolism (VTE) is an important immune-related adverse event (irAE) associated with immune checkpoint inhibitors (ICI) cancer therapy. To better understand the pathogenesis of ICI-induced VTE during ICI treatment, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d04a2866e471c61739696d7c4ec9ae
https://doi.org/10.1182/blood-2021-154228
https://doi.org/10.1182/blood-2021-154228
Publikováno v:
Biochemical and Biophysical Research Communications. 482:1407-1412
Clusterin is a secretory glycoprotein that is up-regulated in areas of inflammation and under increased levels of oxidative stress. Previously, we demonstrated that clusterin activates NF-κB, and up-regulates the expression of MMP-9 and TNF-α. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44194b0e2d5d2fe92c74d566277880b7
https://doi.org/10.1016/j.bbrc.2016.12.049
https://doi.org/10.1016/j.bbrc.2016.12.049