Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Young-Jin Im"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 4, Pp 289-296 (2006)
Abstract.: Dimethylsphingosine (DMS) was first reported as an inhibitor of protein kinase C and later has been used as a specific inhibitor of sphingosine kinase. Furthermore, its anti-cancer effect has become a basis for development of chemotherapy.
Externí odkaz:
https://doaj.org/article/392cb3bc2b6b44a28293fc1e1eb6ac7e
Autor:
Young-Jin Im, Dong-Soon Im, Yun-Kyung Lee, Eun-Hee Lee, Koichi Sato, Hideaki Tomura, Toshiaki Katada, Michio Ui, Fumikazu Okajima
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 443-446 (2005)
Sphingosine-1-phosphate (S1P) acts on a set of G protein-coupled receptors in the plasma membrane and also as a second messenger in certain cell types. There are two possible pathways to mobilize intracellular Ca2+ concentration by S1P. One is throug
Externí odkaz:
https://doaj.org/article/3329e06e16ac46939b3cabb1f09fc791
Autor:
Young-Jin Im, Myeong-Hun Lee
Publikováno v:
The Journal of the Korea Contents Association. 16:348-358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d83ce9003aa9d9a0900ed88d179da2cd
https://doi.org/10.5392/jkca.2016.16.07.348
https://doi.org/10.5392/jkca.2016.16.07.348
Publikováno v:
Prostaglandins & Other Lipid Mediators. 83:130-138
Fetal bovine serum (FBS) was found to protect Jurkat T cells from LPC-induced cytotoxicity. Twenty micromolar LPC-induced cytotoxicity of 80–90% of the cells in media without FBS for 3 h, whereas 50–70% in media with 0.5% FBS. However, LPC-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a952be1550e812c8eb726d8a03b1a51
https://doi.org/10.1016/j.prostaglandins.2006.10.006
https://doi.org/10.1016/j.prostaglandins.2006.10.006
Autor:
Yoe Sik Bae, Nam-Chul Ha, Yun Kyung Lee, Yu-Lee Kim, Young Jin Im, Fumikazu Okajima, Sung Mee Lim, Dong Soon Im
Publikováno v:
Biochemical and Biophysical Research Communications. 351:953-957
Jurkat T cells were found to adhere to a tissue culture flask or cover glass when 10% fetal bovine serum (FBS) was withdrawn. However, the cells adhered to extracellular matrix, especially fibronectin, regardless of the presence of FBS. We hypothesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8447446b669b591348de4ef4b14f6c
https://doi.org/10.1016/j.bbrc.2006.10.143
https://doi.org/10.1016/j.bbrc.2006.10.143
Publikováno v:
Acta Pharmacologica Sinica. 27:700-707
Aim: To obtain pathophysiological meanings of lysophosphatidylcholine (LPC) through the investigation of the effects of LPC in Jurkat T cells. Methods: We measured ROS generation, [Ca 2+ ]i, and mitochondrial membrane potential (MMP) by fluorescent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90621ec8dfedb1fd5821d1c472e52823
https://doi.org/10.1111/j.1745-7254.2006.00339.x
https://doi.org/10.1111/j.1745-7254.2006.00339.x
Autor:
Young-Jin Im, Yu-Lee Kim, Sung-Mee Lim, Dong-Soon Im, Sung-Ryong Ko, Yun-Kyung Lee, Hyo-Lim Kim, Kyeok Kim, Santosh J. Sacket
Publikováno v:
Journal of Ginseng Research. 30:70-77
Ginseng has an anti-cancer effect in several cancer models. As a mechanism study of ginsenoside-induced growth inhibition in cancer cells, we measured change of membrane potential in prostate cancer and glioma cells by ginsenosides, active constituen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f3c8a78f84fde35193a7925ea88aa8e
https://doi.org/10.5142/jgr.2006.30.2.070
https://doi.org/10.5142/jgr.2006.30.2.070
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 4, Pp 289-296 (2006)
Dimethylsphingosine (DMS) was first reported as an inhibitor of protein kinase C and later has been used as a specific inhibitor of sphingosine kinase. Furthermore, its anti-cancer effect has become a basis for development of chemotherapy. Neverthele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceaf2c2ca098f6e98293d64de8183867
http://www.sciencedirect.com/science/article/pii/S1347861319345062
http://www.sciencedirect.com/science/article/pii/S1347861319345062
Publikováno v:
Biochemical and biophysical research communications. 348(3)
Calcium is a ubiquitous second messenger controlling a broad range of cellular functions. We previously observed that N,N-dimethyl-D-ribo-phytosphingosine (DMPH) and lysophosphatidylcholine (LPC) induced Ca2+ influx across the plasma membrane in U937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae41428dcaa599c8c5042b84a11797d8
https://pubmed.ncbi.nlm.nih.gov/16904073
https://pubmed.ncbi.nlm.nih.gov/16904073
Publikováno v:
Acta pharmacologica Sinica. 27(6)
To obtain pathophysiological meanings of lysophosphatidylcholine (LPC)through the investigation of the effects of LPC in Jurkat T cells .We measured ROS generation, [Ca(2+)](i), and mitochondrial membrane potential (MMP)by fluorescent spectrometry in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2498233db32de0e1f1d10039aaafbaac
https://pubmed.ncbi.nlm.nih.gov/16723088
https://pubmed.ncbi.nlm.nih.gov/16723088