Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Young-Goo Han"'
Autor:
Beth Mann, Jeremy Chase Crawford, Kavya Reddy, Josi Lott, Yong Ha Youn, Geli Gao, Cliff Guy, Ching-Heng Chou, Daniel Darnell, Sanchit Trivedi, Perrine Bomme, Allister J. Loughran, Paul G. Thomas, Young-Goo Han, Elaine I. Tuomanen
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Microbial components have a range of direct effects on the fetal brain. However, little is known about the cellular targets and molecular mechanisms that mediate these effects. Neural progenitor cells (NPCs) control the size and architecture
Externí odkaz:
https://doaj.org/article/edfca55a494f487c9d53c10181500628
Autor:
Yvan Campos, Xiaohui Qiu, Elida Gomero, Randall Wakefield, Linda Horner, Wojciech Brutkowski, Young-Goo Han, David Solecki, Sharon Frase, Antonella Bongiovanni, Alessandra d’Azzo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Correct assembly of intercellular junctions is required to maintain epithelial polarity and barrier function. Here Campos et al. show that the scaffold protein Alix interacts with F-actin, the Par complex and ZO-1 to ensure the formation and maintena
Externí odkaz:
https://doaj.org/article/c1feeee6b4234f208945cf8f377982ec
Autor:
Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong-Dong Wang, Hongjian Jin, Yiping Fan, Patrick J. Connelly, Shondra M. Pruett-Miller, Miaofen G. Hu, Philip W. Hinds, Young-Goo Han
The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b387c5f2eae15f27762454b0e12ca9b0
https://doi.org/10.1101/2022.05.24.493266
https://doi.org/10.1101/2022.05.24.493266
Autor:
Ching-Heng Chou, Elaine Tuomanen, Allister J. Loughran, Cliff Guy, Beth Mann, Young-Goo Han, Paul G. Thomas, Perrine Bomme, Josi Lott, Kavya Reddy, Daniel Darnell, Geli Gao, Yong Ha Youn, Sanchit Trivedi, Jeremy Chase Crawford
SummaryBacterial cell wall, a universal pathogen-associated molecular pattern (PAMP), crosses the placenta into the fetal brain. We determined that PAMPs interact with TLR2/6 on murine fetal neural progenitor cells (NPCs) to induce overexpansion of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f13217ef3b2ede634d35fcedbca16d49
https://doi.org/10.1101/2021.10.19.464985
https://doi.org/10.1101/2021.10.19.464985
Publikováno v:
Cereb Cortex
The neocortex, the center for higher brain function, emerged in mammals and expanded in the course of evolution. The expansion of outer radial glia (oRGs) and intermediate progenitor cells (IPCs) plays key roles in the expansion and consequential fol
The neocortex, the center for higher brain function, emerged in mammals and expanded in the course of evolution. The expansion of outer radial glia (oRGs) and intermediate progenitor cells (IPCs) plays key roles in the expansion and consequential fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c2ebeab889853d790c66a39a78ff209
https://doi.org/10.1101/2021.04.12.439562
https://doi.org/10.1101/2021.04.12.439562
Autor:
A. Denise R. Garcia, Rebecca A. Ihrie, W. Todd Farmer, Corey C. Harwell, Young-Goo Han, Jason W. Triplett
Publikováno v:
The Journal of Neuroscience. 38:9338-9345
Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region and cell-type identity during embryonic morphogenesis. This mini-review accompanies a 2018 SFN mini-symposium that addresses an emerging body of research focu
Publikováno v:
Cerebral Cortex.
The neocortex, the center for higher brain function, emerged in mammals and expanded in the course of evolution. The expansion of outer radial glia (oRGs) and intermediate progenitor cells (IPCs) plays key roles in the expansion and consequential fol
Publikováno v:
Nature neuroscience
The unique mental abilities of humans are rooted in the immensely expanded and folded neocortex, which reflects the expansion of neural progenitors, especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IP
Autor:
David Finkelstein, Elmar Wolf, Yong Ha Youn, BaoHan T. Vo, Martin Eilers, Jerold E. Rehg, Susanne Walz, Martine F. Roussel, Brian L. Murphy, Anneli Gebhardt, Daisuke Kawauchi, Young-Goo Han
Publikováno v:
Cancer Cell. 29:5-16
Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs,