Zobrazeno 1 - 10 of 67 pro vyhledávání: '"Young-Choon Moon"'
1
Akademický článek
Small molecule splicing modifiers with systemic HTT-lowering activity
Autor: Anuradha Bhattacharyya, Christopher R. Trotta, Jana Narasimhan, Kari J. Wiedinger, Wencheng Li, Kerstin A. Effenberger, Matthew G. Woll, Minakshi B. Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M. Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A. Naryshkin, Jason D. Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M. Colacino, Stuart W. Peltz
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here the authors describe the discovery of a class of small molecule splicing modifiers which are orally bioavailable, cross the blood-brain barrier, and lower levels of huntingtin in a mouse model of Huntington’s disease (HD).
Externí odkaz: https://doaj.org/article/7d4bfc4e0c074bdc9d52a1e84c8c63c4
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2
Akademický článek
In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren
Autor: Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Young‐Choon Moon, Ellen M. Welch, Marla Weetall, Joseph M. Colacino, Neil Almstead, John Babiak, Elizabeth Goodwin
Publikováno v: Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potentia
Externí odkaz: https://doaj.org/article/eec39a36fe20492083ddc177954b3161
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3
Akademický článek
The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.
Autor: Westley J Friesen, Briana Johnson, Jairo Sierra, Jin Zhuo, Priya Vazirani, Xiaojiao Xue, Yuki Tomizawa, Ramil Baiazitov, Christie Morrill, Hongyu Ren, Suresh Babu, Young-Choon Moon, Art Branstrom, Anna Mollin, Jean Hedrick, Josephine Sheedy, Gary Elfring, Marla Weetall, Joseph M Colacino, Ellen M Welch, Stuart W Peltz
Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0206158 (2018)
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are responsible for thousands of inherited diseases. Readthrough of premature stop codons by small molecule drugs has emerged as a promising therapeutic approa
Externí odkaz: https://doaj.org/article/dce988ac8f214e27afc02d4bfe8cf531
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4
Akademický článek
Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.
Autor: Liangxian Cao, Marla Weetall, Jenelle Bombard, Hongyan Qi, Tamil Arasu, William Lennox, Jean Hedrick, Josephine Sheedy, Nicole Risher, Peter C Brooks, Panayiota Trifillis, Christopher Trotta, Young-Choon Moon, John Babiak, Neil G Almstead, Joseph M Colacino, Thomas W Davis, Stuart W Peltz
Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168366 (2016)
Current anti-VEGF (Vascular Endothelial Growth Factor A) therapies to treat various cancers indiscriminately block VEGF function in the patient resulting in the global loss of VEGF signaling which has been linked to dose-limiting toxicities as well a
Externí odkaz: https://doaj.org/article/429e9fa300c64e3997b2fda5fbe6a256
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