Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Young-Chan Park"'
Autor:
Arthur Gilly, Young-Chan Park, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101810- (2023)
Objectives: Global cardiometabolic disease prevalence has grown rapidly over the years, making it the leading cause of death worldwide. Proteins are crucial components in biological pathways dysregulated in disease states. Identifying genetic compone
Externí odkaz:
https://doaj.org/article/24680c66ee2d4a1aa5d33dc646d76cd6
Publikováno v:
HGG Advances, Vol 4, Iss 3, Pp 100214- (2023)
Summary: Genetic prediction of common complex disease risk is an essential component of precision medicine. Currently, genome-wide association studies (GWASs) are mostly composed of European-ancestry samples and resulting polygenic scores (PGSs) have
Externí odkaz:
https://doaj.org/article/de41a354cbaf40668413c451b013d366
Autor:
Arthur Gilly, Lucija Klaric, Young-Chan Park, Grace Png, Andrei Barysenka, Joseph A. Marsh, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, James F. Wilson, Eleftheria Zeggini
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101509- (2022)
Objective: Deep sequencing offers unparalleled access to rare variants in human populations. Understanding their role in disease is a priority, yet prohibitive sequencing costs mean that many cohorts lack the sample size to discover these effects on
Externí odkaz:
https://doaj.org/article/15f2ee78d2c847708e47b9c89c0c5823
Autor:
Arthur Gilly, Young-Chan Park, Grace Png, Andrei Barysenka, Iris Fischer, Thea Bjørnland, Lorraine Southam, Daniel Suveges, Sonja Neumeyer, N. William Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the
Externí odkaz:
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
Autor:
SeungHee Jung, Young Chan Park, DongHee Lee, SiYeon Kim, Sang-Mo Kim, YoungJin Kim, DongHyun Lee, JaeJoung Hyun, InSong Koh, Jong-Young Lee
Publikováno v:
Ophthalmic Genetics. 44:163-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e8a5b6dbd77a2e6867b594d1174c663
https://doi.org/10.1080/13816810.2022.2138456
https://doi.org/10.1080/13816810.2022.2138456
Publikováno v:
Clinical & Experimental Vaccine Research. Sep2021, Vol. 10 Issue 3, p252-258. 7p.
Autor:
Peter Kreitmaier, Young-Chan Park, Diane Swift, Arthur Gilly, J Mark Wilkinson, Eleftheria Zeggini
Osteoarthritis is a prevalent, complex disease of the joints, and affects multiple intra-articular tissues. Here, we have examined genome-wide DNA methylation profiles of primary infrapatellar fat pad and matched blood samples from 70 osteoarthritis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bafdce4a7093e4c77f7a76786c027a9
https://doi.org/10.1101/2023.05.22.23290348
https://doi.org/10.1101/2023.05.22.23290348
Publikováno v:
Journal of the Korea Academia-Industrial cooperation Society. 22:700-708
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::853e1dead504d6e3e53d1a55d6dccd07
https://doi.org/10.5762/kais.2021.22.9.700
https://doi.org/10.5762/kais.2021.22.9.700
Publikováno v:
Clinical & Experimental Vaccine Research. Jul2020, Vol. 9 Issue 2, p126-132. 7p.
Autor:
Grace Png, Emmanouil Tsafantakis, Iris Fischer, N. William Rayner, Daniel Suveges, George Dedoussis, Andrei Barysenka, Arthur Gilly, Sonja Neumeyer, Lorraine Southam, Thea Bjørnland, Maria Karaleftheri, Young-Chan Park, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
Nature Communications
Nat. Commun. 11:6336 (2020)
The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571b46eb8d5837c975f58d0af3d41717
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f
https://doaj.org/article/641fcf7725ae4b8ab2f58f76c9c92e4f