Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Young T. Hong"'
Autor:
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translatio
Externí odkaz:
https://doaj.org/article/ab6733cf5df64638bd28121108e81c94
Autor:
Maura Malpetti, Negin Holland, P. Simon Jones, Rong Ye, Thomas E. Cope, Tim D. Fryer, Young T. Hong, George Savulich, Timothy Rittman, Luca Passamonti, Elijah Mak, Franklin I. Aigbirhio, John T. O’Brien, James B. Rowe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 7, Pp 1515-1523 (2021)
Abstract Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [11C]UCB‐J PET to quantify synaptic density in compar
Externí odkaz:
https://doaj.org/article/28737b54cd6649fbb8471e172f44ff20
Autor:
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F. Carter, Elijah Mak, Young T. Hong, Selena Milicevic Sephton, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O’Brien
Publikováno v:
European Journal of Hybrid Imaging, Vol 4, Iss 1, Pp 1-7 (2020)
Abstract Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using po
Externí odkaz:
https://doaj.org/article/635372aa80de47148e5ac5852312c09b
Autor:
Laith Alexander, Christian M. Wood, Philip L. R. Gaskin, Stephen J. Sawiak, Tim D. Fryer, Young T. Hong, Lauren McIver, Hannah F. Clarke, Angela C. Roberts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Alexander et al. causally implicate over-activity in primate subgenual cingulate in affective and cardiovascular dysfunction relevant to anxiety and depression. Over-activation led to elevated activity in a stress-related network whilst decreasing ac
Externí odkaz:
https://doaj.org/article/c4882c5246f44a9f9ba8c63aa0cd943b
Autor:
Elijah Mak, Anastasia Bickerton, Concepcion Padilla, Madeleine J. Walpert, Tiina Annus, Liam R. Wilson, Young T. Hong, Tim D. Fryer, Jonathan P. Coles, Franklin I. Aigbirhio, Bradley T. Christian, Benjamin L. Handen, William E. Klunk, David K. Menon, Peter J. Nestor, Shahid H. Zaman, Anthony J. Holland
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 654-658 (2019)
Abstract Introduction Comorbid Alzheimer disease pathologies are frequently found in people with Down syndrome (DS). We report a deep phenotyping study undertaken over 7 years in a participant with DS who was nondemented at baseline but developed dem
Externí odkaz:
https://doaj.org/article/cf9f58123da64fa0b0dfa7a35446bd59
Autor:
Marian Galovic, Kjell Erlandsson, Tim D. Fryer, Young T. Hong, Roido Manavaki, Hasan Sari, Sarah Chetcuti, Benjamin A. Thomas, Martin Fisher, Selena Sephton, Roberto Canales, Joseph J Russell, Kerstin Sander, Erik Årstad, Franklin I. Aigbirhio, Ashley M. Groves, John S. Duncan, Kris Thielemans, Brian F. Hutton, Jonathan P. Coles, Matthias J. Koepp
Publikováno v:
NeuroImage, Vol 237, Iss , Pp 118194- (2021)
Blood-based kinetic analysis of PET data relies on an accurate estimate of the arterial plasma input function (PIF). An alternative to invasive measurements from arterial sampling is an image-derived input function (IDIF). However, an IDIF provides t
Externí odkaz:
https://doaj.org/article/57d2611920154aa588abda4ba324fa91
Autor:
Kathy Y. Liu, Julio Acosta-Cabronero, Young T. Hong, Yeo-Jin Yi, Dorothea Hämmerer, Robert Howard
Publikováno v:
Neuroimage: Reports, Vol 1, Iss 1, Pp 100002- (2021)
Sensitive and reliable in vivo imaging of the locus coeruleus (LC) is important to develop and evaluate its potential as a biomarker in neurodegenerative diseases such as Alzheimer’s disease (AD). It is not known whether AD-related alterations in L
Externí odkaz:
https://doaj.org/article/ca6480957eea44ebb4b67b726411c52a
Autor:
Nicolas Nicastro, Elijah Mak, Guy B. Williams, Ajenthan Surendranathan, W Richard Bevan-Jones, Luca Passamonti, Patricia Vàzquez Rodrìguez, Li Su, Robert Arnold, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, James B. Rowe, John T. O'Brien
Publikováno v:
NeuroImage: Clinical, Vol 25, Iss , Pp - (2020)
Dementia with Lewy bodies (DLB) is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer's pathology. Neuroinflammation is also increasingly recognized as a significant contributor to degeneration. We aimed
Externí odkaz:
https://doaj.org/article/849c0de96fee4c9bb848a84cdc801a14
Autor:
Elijah Mak, Richard A.I. Bethlehem, Rafael Romero‐Garcia, Simon Cervenka, Timothy Rittman, Silvy Gabel, Ajenthan Surendranathan, Richard W. Bevan‐Jones, Luca Passamonti, Patricia Vázquez Rodríguez, Li Su, Robert Arnold, Guy B. Williams, Young T. Hong, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O'Brien
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 678-687 (2018)
Abstract Introduction The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain uncle
Externí odkaz:
https://doaj.org/article/d3adbe28210e455d801b9f9de18e1e10
Autor:
Julius V. Emmrich, Sohail Ejaz, David J. Williamson, Young T. Hong, Sergey Sitnikov, Tim D. Fryer, Franklin I. Aigbirhio, Heike Wulff, Jean-Claude Baron
Publikováno v:
Brain Sciences, Vol 9, Iss 10, p 287 (2019)
Although early reperfusion after stroke salvages the still-viable ischemic tissue, peri-infarct selective neuronal loss (SNL) can cause sensorimotor deficits (SMD). We designed a longitudinal protocol to assess the effects of cytoprotectants on SMD,
Externí odkaz:
https://doaj.org/article/2dbfc82586494e6698c01476b5754307