Zobrazeno 1 - 10 of 138 pro vyhledávání: '"Young Sook Kang"'
1
Akademický článek
Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis
Autor: Asmita Gyawali, Sana Latif, Seung-Hye Choi, Seung Jae Hyeon, Hoon Ryu, Young-Sook Kang
Publikováno v: Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-13 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic drug and a histone deace
Externí odkaz: https://doaj.org/article/eb30216ec30847e198fed6c72e2c474e
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2
Akademický článek
Protective Effects of Choline against Inflammatory Cytokines and Characterization of Transport in Motor Neuron-like Cell Lines (NSC-34)
Autor: Sana Latif, Young-Sook Kang
Publikováno v: Pharmaceutics, Vol 14, Iss 11, p 2374 (2022)
Choline, a component of the neurotransmitter acetylcholine, is essential for nervous system functions, brain development, and gene expression. In our study, we investigated the protective effect and transport characteristics of choline in amyotrophic
Externí odkaz: https://doaj.org/article/f10b462652244284b183979816fa081d
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3
Akademický článek
Blood–Brain Barrier Solute Carrier Transporters and Motor Neuron Disease
Autor: Sana Latif, Young-Sook Kang
Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2167 (2022)
Defective solute carrier (SLC) transporters are responsible for neurotransmitter dysregulation, resulting in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We provided the role and kinetic parameters of transporters such as A
Externí odkaz: https://doaj.org/article/a1dd51673f0e401492cbe778c12e2e1b
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4
Akademický článek
Antioxidant and Neuroprotective Effects of Paeonol against Oxidative Stress and Altered Carrier-Mediated Transport System on NSC-34 Cell Lines
Autor: Sana Latif, Seung-Hye Choi, Asmita Gyawali, Seung Jae Hyeon, Young-Sook Kang, Hoon Ryu
Publikováno v: Antioxidants, Vol 11, Iss 7, p 1392 (2022)
Paeonol is a naturally occurring phenolic agent that attenuates neurotoxicity in neurodegenerative diseases. We aimed to investigate the antioxidant and protective effects of paeonol and determine its transport mechanism in wild-type (WT; NSC-34/hSOD
Externí odkaz: https://doaj.org/article/f79c1d4aa421454aa60ab939a4b4ae2f
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6
Akademický článek
Differences of Transport Activity of Arginine and Regulation on Neuronal Nitric Oxide Synthase and Oxidative Stress in Amyotrophic Lateral Sclerosis Model Cell Lines
Autor: Sana Latif, Young-Sook Kang
Publikováno v: Cells, Vol 10, Iss 12, p 3554 (2021)
L-Arginine, a semi-essential amino acid, was shown to delay dysfunction of motor neurons and to prolong the lifespan, upon analysis of transgenic mouse models of amyotrophic lateral sclerosis (ALS). We investigated the transport function of arginine
Externí odkaz: https://doaj.org/article/b1140d38f74348cd9df52024214423bb
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7
Akademický článek
Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)
Autor: Kyeong-Eun Lee, Young-Sook Kang
Publikováno v: Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-10 (2017)
Abstract Background L-Citrulline is a neutral amino acid and a major precursor of L-arginine in the nitric oxide (NO) cycle. Recently it has been reported that L-citrulline prevents neuronal cell death and protects cerebrovascular injury, therefore,
Externí odkaz: https://doaj.org/article/4a50d097c2fe4d7fb501f09ac03a89f3
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8
Akademický článek
The Alteration of L-Carnitine Transport and Pretreatment Effect under Glutamate Cytotoxicity on Motor Neuron-Like NSC-34 Lines
Autor: Asmita Gyawali, Seung Jae Hyeon, Hoon Ryu, Young-Sook Kang
Publikováno v: Pharmaceutics, Vol 13, Iss 4, p 551 (2021)
L-Carnitine (LC) is essential for transporting fatty acids to the mitochondria for β-oxidation. This study was performed to examine the alteration of the LC transport system in wild type (WT, NSC-34/hSOD1WT) and mutant type (MT, NSC-34/hSOD1G93A) am
Externí odkaz: https://doaj.org/article/2efa6cea00354dc0b92618a09f792b36
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9
Akademický článek
Pretreatment Effect of Inflammatory Stimuli and Characteristics of Tryptophan Transport on Brain Capillary Endothelial (TR-BBB) and Motor Neuron Like (NSC-34) Cell Lines
Autor: Asmita Gyawali, Young-Sook Kang
Publikováno v: Biomedicines, Vol 9, Iss 1, p 9 (2020)
Tryptophan plays a key role in several neurological and psychiatric disorders. In this study, we investigated the transport mechanisms of tryptophan in brain capillary endothelial (TR-BBB) cell lines and motor neuron-like (NSC-34) cell lines. The upt
Externí odkaz: https://doaj.org/article/e8f14c87e21b4ca882ba1234345e4bd9
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10
Change in Cationic Amino Acid Transport System and Effect of Lysine Pretreatment on Inflammatory State in Amyotrophic Lateral Sclerosis Cell Model
Autor: Sana Latif, Young-Sook Kang
Publikováno v: Biomolecules & Therapeutics
Amyotrophic lateral sclerosis (ALS) is a lethal neurological disorder characterized by the deterioration of motor neurons. The aim of this study was to investigate alteration of cationic amino acid transporter (CAT-1) activity in the transport of lys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6454cfaf64bf702a11db2554d033d78
https://doi.org/10.4062/biomolther.2021.037
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