Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Young Seomun"'
Coagulant Effect and Tolerability of Yeast-Produced Recombinant Batroxobin in Healthy Adult Subjects
Publikováno v:
Clinical Drug Investigation. 38:829-835
Batroxobin, a snake venom thrombin-like enzyme, converts fibrinogen into fibrin by cleaving fibrinopeptide A. It is used for hemostasis; however, the supply of native batroxobin is limited. Therefore, we developed a recombinant batroxobin (r-batroxob
Autor:
Mi Hee Lee, Min Ah Koo, Min Sung Kim, Gyeung Mi Seon, Jong Chul Park, Jong Tak Kim, Do Hyun Kim, Young Seomun, Byeong Ju Kwon
Publikováno v:
Acta Biomaterialia. 48:175-185
Although a number of natural materials have been used as hemostatic agents, many substances do not act quickly enough. Here, we created a novel dressings using collagen and chitosan with recombinant batroxobin (r-Bat) to promote faster and more effec
Coagulant Effect and Tolerability of Yeast-Produced Recombinant Batroxobin in Healthy Adult Subjects
Publikováno v:
Clinical drug investigation. 38(9)
Batroxobin, a snake venom thrombin-like enzyme, converts fibrinogen into fibrin by cleaving fibrinopeptide A. It is used for hemostasis; however, the supply of native batroxobin is limited. Therefore, we developed a recombinant batroxobin (r-batroxob
Autor:
Jong Chul Park, Min Ah Koo, Min Sung Kim, Jong Tak Kim, Gyeung Mi Seon, Mi Hee Lee, Young Seomun, Byeong Ju Kwon, Tae Hee Kim
Publikováno v:
International journal of biological macromolecules. 113
The choice of hemostat is determined by the situation and the degree of hemorrhage. One common hemostat, the nonwoven dressing, is easy to handled and controls severe bleeding on wider wounds. In this study, chitosan-based nonwoven dressings with rec
Publikováno v:
Food Science and Biotechnology. 24:1845-1852
Previously our research found that caffeic acid (CA) has antioxidant activity in vitro and in vivo. However, the antioxidant mechanism of CA has not been clearly demonstrated. We investigated the protective mechanism of CA on oxidative stress in HepG
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 129
Recombinant batroxobin is a thrombin-like enzyme of Bothrops atrox moojeni venom. To evaluate its toxicological effect, it was highly expressed in Pichia pastorisand successfully purified to homogeneity from culture broth supernatant following Good M
Publikováno v:
Ophthalmic Research. 40:273-278
Purpose: This study was performed to elucidate the role of nuclear factor ĸB (NF-ĸB) in lens epithelial cell proliferation in the capsular bag model for this study. Methods: Capsular bags were prepared from porcine eyes and cultured in a 5% CO2 atm
Autor:
Mi Hee Lee, Jong Tak Kim, Dae Hyung Lee, Kyung Eun You, Jong Chul Park, Min Ah Koo, Suong-Hyu Hyon, Byeong Ju Kwon, Young Seomun
Publikováno v:
Biomedical materials (Bristol, England). 9(2)
Many types of hemostatic agents have been studied for the effective control of bleeding. In this study, a powdery medical adhesive composed of aldehyded dextran and e-poly (L-lysine) was used with the recombinant batroxobin. Batroxobin is a venomous
Publikováno v:
Biochemical Journal. 358:41-48
Transforming growth factor-β (TGF-β) is known to be a causative factor in pathological fibrosis and the metastasis of cancer cells, through effects on molecules of the extracellular matrix (ECM). We evaluated the influence of TGF-β1 on the gene ex
Autor:
Choun-Ki Joo, Jeong-a Kim, Young Seomun, Sang Kyu Park, Sung-Kun Chung, Inn-Oc Han, Jongkyu Choi, Eunjoo H. Lee, Dong-Hwan Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 284:966-971
Connective tissue growth factor (CTGF) has recently been described as a fibrogenic factor and is greatly induced by various extracellular stimuli, such as transforming growth factor-beta (TGF-beta), dexamethasone, and serotonin. CTGF induces collagen