An RNA-centric view of transcription and genome organization.

Autor: Henninger JE; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: jhenning@andrew.cmu.edu., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu.

Publikováno v: Molecular cell [Mol Cell] 2024 Oct 03; Vol. 84 (19), pp. 3627-3643.

Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the prefrontal cortex and hippocampus.

Autor: Ding M; Graduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA., Tomsick PL; Undergraduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA.; Department of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA., Young RA; Department of Psychology, Brandeis University, Waltham, MA, 02453, USA., Jadhav SP; Graduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA.; Department of Psychology, Brandeis University, Waltham, MA, 02453, USA.; Volen National Center for Complex Systems, Brandeis University, Waltham, MA, 02453, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 10. Date of Electronic Publication: 2024 Sep 10.

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

Autor: Liu Y; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Flamier A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Bell GW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Diao AJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Whitfield TW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Wang HC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Wu Y; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Schulte F; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Friesen M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Guo R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Mitalipova M; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Liu XS; Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032, USA., Vos SM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: jaenisch@wi.mit.edu.

Publikováno v: Neuron [Neuron] 2024 Jun 19; Vol. 112 (12), pp. 1943-1958.e10. Date of Electronic Publication: 2024 May 01.

Matrine suppresses KRAS‐driven pancreatic cancer growth by inhibiting autophagy‐mediated energy metabolism

Autor: Young‐ra Cho, Ji Hyeon Lee, Ji Hye Kim, So‐Yeon Lee, Suna Yoo, Min‐kyo Jung, Su Jung Kim, Hyun Ju Yoo, Chang‐Gi Pack, Jin Kyung Rho, Jaekyoung Son

Publikováno v: Molecular Oncology, Vol 12, Iss 7, Pp 1203-1215 (2018)

Matrine is a natural compound extracted from the herb Sophora flavescens Ait which is widely used in traditional Chinese medicine for treating various diseases. Recently, matrine was reported to have antitumor effects against a variety of cancers wit

Externí odkaz: https://doaj.org/article/9e04818d4c0d4054b4cb55b765f92ee7

Patient Partnership Tools to Support Medication Safety in Community-Dwelling Older Adults: Protocol for a Nonrandomized Stepped Wedge Clinical Trial.

Autor: Xiao Y; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States.; College of Engineering, University of Texas at Arlington, Arlington, TX, United States., Fulda KG; Department of Family Medicine and Osteopathic Manipulative Medicine and North Texas Primary Care Practice-Based Research Network (NorTex), University of North Texas Health Science Center, Fort Worth, TX, United States., Young RA; Family Medicine Residency Program, John Peter Smith Health Network, Fort Worth, TX, United States., Hendrix ZN; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States., Daniel KM; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States., Chen KY; College of Business, University of Texas at Arlington, Arlington, TX, United States., Zhou Y; College of Engineering, University of Texas at Arlington, Arlington, TX, United States., Roye JL; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States., Kosmari L; College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States., Wilson J; College of Liberal Arts, University of Texas at Arlington, Arlington, TX, United States., Espinoza AM; Department of Family Medicine and Osteopathic Manipulative Medicine and North Texas Primary Care Practice-Based Research Network (NorTex), University of North Texas Health Science Center, Fort Worth, TX, United States., Sutcliffe KM; Carey Business School, Johns Hopkins University, Baltimore, MD, United States.; School of Medicine, Johns Hopkins University, Baltimore, MD, United States.; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.; School of Nursing, Johns Hopkins University, Baltimore, MD, United States., Pitts SI; School of Medicine, Johns Hopkins University, Baltimore, MD, United States., Arbaje AI; School of Medicine, Johns Hopkins University, Baltimore, MD, United States.; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Chui MA; School of Pharmacy, University of Wisconsin-Madison, Madison, WI, United States., Blair S; Office of Clinical Research, John Peter Smith Health Network, Fort Worth, TX, United States., Sloan D; Family Medicine Residency Program, John Peter Smith Health Network, Fort Worth, TX, United States., Jackson M; Family Medicine Residency Program, John Peter Smith Health Network, Fort Worth, TX, United States., Gurses AP; School of Medicine, Johns Hopkins University, Baltimore, MD, United States.; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.; Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.

Publikováno v: JMIR research protocols [JMIR Res Protoc] 2024 Apr 29; Vol. 13, pp. e57878. Date of Electronic Publication: 2024 Apr 29.