Výsledky vyhledávání - "Young Keul Jeon"

Akademický článek

Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids

Autor: Myeongjin Song, Da Bin Choi, Jeong Suk Im, Ye Na Song, Ji Hyun Kim, Hanbyeol Lee, Jieun An, Ami Kim, Hwan Choi, Joon-Chul Kim, Choongseong Han, Young Keul Jeon, Sung Joon Kim, Dong-Hun Woo

Publikováno v: Cell Death and Disease, Vol 15, Iss 5, Pp 1-13 (2024)

Abstract Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models have been proposed as complementary approaches to non-clinical animal research. However, most

Externí odkaz: https://doaj.org/article/b2975d96d1a74e2eb82a26faa70d7b1c

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Akademický článek

Suppression of hERG K+ current and cardiac action potential prolongation by 4-hydroxynonenal via dual mechanisms

Autor: Seong Woo Choi, Si Won Choi, Young Keul Jeon, Sung-Hwan Moon, Yin-Hua Zhang, Sung Joon Kim

Publikováno v: Redox Biology, Vol 19, Iss , Pp 190-199 (2018)

Oxidative stress under pathological conditions, such as ischemia/reperfusion and inflammation, results in the production of various reactive chemicals. Of these chemicals, 4-hydroxynonenal (4-HNE), a peroxidation product of ω6-polyunsaturated fatty

Externí odkaz: https://doaj.org/article/3d543b6bc8d5413e814bedfc5d0e2c9d

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Akademický článek

Bidirectional sensitivity of CALHM1 channel to protons from both sides of plasma membrane.

Autor: Jae Won Kwon, Young Keul Jeon, Sung Joon Kim

Publikováno v: American Journal of Physiology: Cell Physiology; Jan2023, Vol. 324 Issue 1, pC98-C112, 15p

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Intramolecular Disulfide Bonds for Biogenesis of CALHM1 Ion Channel Are Dispensable for Voltage-Dependent Activation

Autor: Young Keul Jeon, Sang Jeong Kim, Jinsung Kim, Sung Joon Kim, Jae Won Kwon

Publikováno v: Molecules and Cells

Calcium homeostasis modulator 1 (CALHM1) is a membrane protein with four transmembrane helices that form an octameric ion channel with voltage-dependent activation. There are four conserved cysteine (Cys) residues in the extracellular domain that for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a874c50bfaaca5b51f1f057635df583
https://doi.org/10.14348/molcells.2021.0131

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Bidirectional sensitivity of CALHM1 channel to protons from both sides of plasma membrane

Autor: Jae Won Kwon, Young Keul Jeon, Sung Joon Kim

Publikováno v: American journal of physiology. Cell physiology. 324(1)

Calcium homeostasis modulator 1 (CALHM1), a newly discovered voltage-dependent nonselective ion channel, has drawn attention for its role in neuronal activity and taste sensation. Its sluggish voltage-dependent activation is facilitated by lowering e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8c04c8782840bc20f69fc44b585450
https://pubmed.ncbi.nlm.nih.gov/36409172

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Abstract P1104: Lower Troponin Expression In The Right Ventricle Of Rats Explains Interventricular Differences In E-c Coupling

Autor: Young Keul Jeon, Jae Won Kwon, Sung Joon Kim

Publikováno v: Circulation Research. 131

Despite distinctive functional and anatomical differences, a precise understanding of the cardiac interventricular differences in excitation-contraction (E-C) coupling mechanisms is still lacking. Here, we directly compared rat right and left cardiom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfe76a4b110df15754d10182b89ecc7b
https://doi.org/10.1161/res.131.suppl_1.p1104

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Higher expression of KCNK10 (TREK-2) K+ channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells

Autor: Kyung Sun Park, Inseong Kho, Seong Woo Choi, Hae Young Yoo, Joohan Woo, Si Won Choi, Young Keul Jeon, Juyeon Ko, Sung Joon Kim, Tae Jin Kim

Publikováno v: Pflügers Archiv - European Journal of Physiology. 473:659-671

Innate-like CD5+ B1a cells localized in serous cavities are activated by innate stimuli, such as lipopolysaccharide (LPS), leading to T cell-independent antibody responses. Although ion channels play crucial roles in the homeostasis and activation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::409b521c5859f6ca906f51ae276ee8da
https://doi.org/10.1007/s00424-021-02526-1

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Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes

Autor: Jae Boum Youm, Chae Hun Leem, Seunghee Lee, Hae Young Yoo, Young Keul Jeon, Joo Han Woo, Sung Joon Kim, Kotdaji Ha

Publikováno v: Advances in Physiology Education. 44:323-333

To understand the excitation-contraction (E-C) coupling of cardiomyocytes, including the electrophysiological mechanism of their characteristically long action potential duration, is one of the major learning goals in medical physiology. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e220aefce4094578ff2ced93bfb91e14
https://doi.org/10.1152/advan.00093.2019

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