Výsledky vyhledávání - "Young K. Cheun"

New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Cross-Links and Their Use to Study Lesion Bypass by DNA Polymerases

Autor: Young K. Cheun, Arnold Groehler, Orlando D. Schärer

Publikováno v: Chemical Research in Toxicology. 34:1790-1799

Nitrogen mustards are a widely used class of antitumor agents that exert their cytotoxic effects through the formation of DNA interstrand cross-links (ICLs). Despite being among the first antitumor agents used, the biological responses to NM ICLs rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e869d1d7ed336c8c59841b3d515a2d3c
https://doi.org/10.1021/acs.chemrestox.1c00123

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Bypass of DNA interstrand crosslinks by a Rev1–DNA polymerase ζ complex

Autor: Rachel Bezalel-Buch, Young K. Cheun, Orlando D. Schärer, Upasana Roy, Peter M. J. Burgers

Publikováno v: Nucleic Acids Research

DNA polymerase ζ (Pol ζ) and Rev1 are essential for the repair of DNA interstrand crosslink (ICL) damage. We have used yeast DNA polymerases η, ζ and Rev1 to study translesion synthesis (TLS) past a nitrogen mustard-based interstrand crosslink (I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49628337bc4eb1007895ba5f0724792c
http://europepmc.org/articles/PMC7470978

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