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pro vyhledávání: '"Young Jung R. Kim"'
Autor:
Ja Young Kim-Muller, Jason Fan, Young Jung R. Kim, Seung-Ah Lee, Emi Ishida, William S. Blaner, Domenico Accili
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Diabetes is associated with the de-differentiation of β-cells into a more progenitor-like cell type. Here, the authors identify Aldh3 as a marker of de-differentiating β-cell in animal models of diabetes, and show Aldh3+cells have impaired insulin
Externí odkaz:
https://doaj.org/article/e17584f62b6c47f0ad9963510af7d64a
Autor:
Emi Ishida, Seung-Ah Lee, Young Jung R. Kim, William S. Blaner, Domenico Accili, Jason Fan, Ja Young Kim-Muller
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates progression from β-cell dysfunction to β-cell dedifferenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cdb12158eaaab46f3e9b520f47877b
https://doaj.org/article/e17584f62b6c47f0ad9963510af7d64a
https://doaj.org/article/e17584f62b6c47f0ad9963510af7d64a
Autor:
Shangang Zhao, Jason Fan, Alexander S. Banks, Ja Young Kim-Muller, Domenico Accili, Young Jung R. Kim, Marc Prentki
Publikováno v:
Journal of Biological Chemistry. 291:10162-10172
Pancreatic β-cell dysfunction contributes to onset and progression of type 2 diabetes. In this state β-cells become metabolically inflexible, losing the ability to select between carbohydrates and lipids as substrates for mitochondrial oxidation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4fedaddb142dd59d0ee2085379d3be
https://doi.org/10.1074/jbc.m115.705608
https://doi.org/10.1074/jbc.m115.705608