Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Young Im Oh"'
1
In Vitro Structure−Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors: 5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives
Autor: Ki Wha Lee, Jin Kwan Kim, Young Im Oh, Jin Kyu Choi, Kyung Min Lim, Joo Hyun Moh, Hyun Ju Koh, Young Hoon Choi, Minsoo Noh, Jiyoung Kim, Youngjoo Byun, Yeon Su Jeong, Song Seok Shin, Young Ho Park, Shin Chung
Publikováno v: Journal of Medicinal Chemistry. 47:792-804
5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives were studied as a novel class of selective cyclooxygenase-2 inhibitors with regard to synthesis, in vitro SAR, antiinflammatory activities, pharmacokinetic considerations, and gastric safety. 1f,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda7c976afc1e64664cf2d21b32596cb
https://doi.org/10.1021/jm020545z
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2
Synthesis and anti-HIV activity of poly(cysteic acid)
Autor: Mark Cushman, Young-im Oh
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2245-2248
Poly(cysteic acid) was synthesized and found to inhibit the cytopathic effect of HIV-1 in CEM cell cultures at concentrations that were not cytotoxic to uninfected CEM cells.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8efeee62d50a11e2679a6d82ec4c1a0
https://doi.org/10.1016/s0960-894x(00)80079-7
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3
Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists
Autor: Barry S. Coller, Masakatsu Eguchi, Iwao Ojima, Clare M. Amann, Young-im Oh, Qing Dong
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1749-1754
A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ea780f836bd48bdc1a6420e141f8c49
https://doi.org/10.1016/s0960-894x(00)80374-1
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4
Development of methodology for the synthesis of stereochemically pure Phe.psi.[CH2N]Pro linkages in HIV protease inhibitors
Autor: Stuart W. Snyder, Mark Cushman, Stephen Oroszlan, Young Im Oh, Terry D. Copeland
Publikováno v: The Journal of Organic Chemistry. 56:4161-4167
One of the strategies currently being pursued for the design of potential HIV protease inhibitors involves the replacement of the cleaved amide bond in a minimum peptide substrate with an aminomethylen? unit. A commonly used method for the synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::675c96f9e8b82a2c72b443719361fa6c
https://doi.org/10.1021/jo00013a017
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6
A facile elaboration of aldehydes to 2-alkyl-3-thiophenylfurans
Autor: Young-Im Oh, Patrick G. McDougal
Publikováno v: Tetrahedron Letters. 27:139-142
A two-step procedure for the elaboration of aldehydes to 2-substituted 3-thiofurans has been developed. The key step involves a site-selective deprotonation of a substituted vinyl sulfide.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3acff05cc4e3fcdf096b2621421bb001
https://doi.org/10.1016/s0040-4039(00)83961-1
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