Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Young Hwan Jung"'
Autor:
Paola Oliva, Asmita Pramanik, Young-Hwan Jung, Sarah A. Lewicki, Jamie M. Mwendwa, Jong Hwan Park, Kenneth A. Jacobson
Publikováno v:
Cells, Vol 13, Iss 16, p 1366 (2024)
The P2Y6 receptor (P2Y6R), a Gq-coupled receptor, is a potential drug discovery target for various inflammatory and degenerative conditions. Antagonists have been shown to attenuate colitis, acute lung injury, etc. In the search for competitive antag
Externí odkaz:
https://doaj.org/article/b9a24a29bcbf4d588c5d7298259993dd
Autor:
Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jürgen Wess, Kenneth A. Jacobson
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels contribute to peripheral insulin resistance, which can ultimately lead to the development of T2D. F
Externí odkaz:
https://doaj.org/article/415ac4152bc74c40af64da7ddcf8b9cd
Autor:
Young-Hwan Jung, Yeo Ok Kim, Koon Mook Kang, Hyung Gon Lee, Borum Son, Xuehao Han, Eunseok Oh, Siwon Kim, Seon Hee Seo, Jong-Hyun Park, Ki Duk Park, Woong Mo Kim, Myung Ha Yoon, Yong-Chul Kim
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 407 (2022)
Neuropathic pain is a chronic and sometimes intractable condition caused by lesions or diseases of the somatosensory nervous system. Many drugs are available but unfortunately do not provide satisfactory effects in patients, producing limited analges
Externí odkaz:
https://doaj.org/article/f336e7f773a0407694da045b1a934c52
Autor:
Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v:
J Med Chem
High affinity phenyl-piperidine P2Y(14)R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556
https://pubmed.ncbi.nlm.nih.gov/35113556
Autor:
Young-Hwan, Jung, Qasim, Shah, Sarah A, Lewicki, Asmita, Pramanik, Varun, Gopinatth, Julie, Pelletier, Jean, Sévigny, Jamshed, Iqbal, Kenneth A, Jacobson
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
P2Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c9c01fbb67fa98beaaa66f6c2e04575
https://pubmed.ncbi.nlm.nih.gov/36089113
https://pubmed.ncbi.nlm.nih.gov/36089113
Autor:
Kenneth A. Jacobson, Donald N. Cook, Tadeusz P Karcz, John C R Randle, John M. Bennett, Varun Gopinatth, Zhiwei Wen, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, David I. Lieberman, Veronica Salmaso, Zhoumou Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:5099-5122
A known zwitterionic, heterocyclic P2Y14R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8619de0d7c2d74a8325f516dd55228e
https://doi.org/10.1021/acs.jmedchem.1c00164
https://doi.org/10.1021/acs.jmedchem.1c00164
Autor:
Kenneth A. Jacobson, Dilip K. Tosh, Zhan-Guo Gao, Monimoy Banerjee, Brian S. J. Blagg, Christopher M. Brackett, Young-Hwan Jung
Publikováno v:
ACS Medicinal Chemistry Letters. 12:373-379
The heat shock protein 90 kDa (Hsp90) family of chaperones is highly sought-after for the treatment of cancer and neurodegenerative diseases. Glucose regulated protein 94 (Grp94) is the endoplasmic...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d332171e57abc0f4dd57584c533c52
https://doi.org/10.1021/acsmedchemlett.0c00509
https://doi.org/10.1021/acsmedchemlett.0c00509
Autor:
Fatma Mufti, Young‐Hwan Jung, Luigino A. Giancotti, Jinha Yu, Zhoumou Chen, Ngan B. Phung, Kenneth A. Jacobson, Daniela Salvemini
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3defa1d8be263e0c4f0ba2477d633fa5
https://doi.org/10.1096/fasebj.2022.36.s1.r2874
https://doi.org/10.1096/fasebj.2022.36.s1.r2874
Publikováno v:
Clinica Chimica Acta; International Journal of Clinical Chemistry
Clinica Chimica Acta
Clinica Chimica Acta
Highlights • A synthetic positive control template system for COVID-19 diagnosis was developed. • The low detection limits of SPT were 10−12 to >10−15 M for different gene targets. • One picogram of patient RNA allowed convincing detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232da616922656dc7df5e2d52edd82c3
https://doi.org/10.1016/j.cca.2020.10.001
https://doi.org/10.1016/j.cca.2020.10.001
Autor:
Kenneth A. Jacobson, Fatma Mufti, Ngan B. Phung, Luigino Antonio Giancotti, Daniela Salvemini, Young-Hwan Jung, Jinha Yu, Zhoumou Chen
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1281-1286
Eight P2Y14R antagonists, including three newly synthesized analogues, containing a naphthalene or phenyl-triazolyl scaffold were compared in a mouse model of chronic neuropathic pain (sciatic constriction). P2Y14R antagonists rapidly (≤30 min) rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5294955a197573842d2dc091376c94e0
https://doi.org/10.1021/acsmedchemlett.0c00115
https://doi.org/10.1021/acsmedchemlett.0c00115