Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Young Hwa Goo"'
Autor:
Young-Hwa Goo, Janeesh Plakkal Ayyappan, Francis D. Cheeran, Sushant Bangru, Pradip K. Saha, Paula Baar, Sabine Schulz, Todd A. Lydic, Bernhard Spengler, Andreas H. Wagner, Auinash Kalsotra, Vijay K. Yechoor, Antoni Paul
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high affinity for LDs of foam cells.
Externí odkaz:
https://doaj.org/article/213b8383686e44778bff5f56edd70410
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators of lipid metabolism and inflammation, two major dr
Externí odkaz:
https://doaj.org/article/a4ef285b06464639b380b9e11c17b716
Autor:
Mariana G. Figueiro, Young‐Hwa Goo, Ryan Hogan, Barbara Plitnick, Jeong‐Kyung Lee, Kiran Jahangir, Mousumi Moulik, Vijay K. Yechoor, Antoni Paul
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 2 (2021)
Background Despite compelling epidemiological evidence that circadian disruption inherent to long‐term shift work enhances atherosclerosis progression and vascular events, the underlying mechanisms remain poorly understood. A challenge to the use o
Externí odkaz:
https://doaj.org/article/d0a4ad155eb8425c8c276b0c296eb5d0
Autor:
Todd A. Lydic, Young-Hwa Goo
Publikováno v:
Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-13 (2018)
Abstract Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quant
Externí odkaz:
https://doaj.org/article/666aed300650435792499a841d40bbc9
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon ol
Externí odkaz:
https://doaj.org/article/787be6507a3d46d9aa68b06ef232133f
Publikováno v:
Genomics Data, Vol 9, Iss C, Pp 37-39 (2016)
Hypercholesterolemia is a main risk factor for atherosclerosis development. Arterial macrophages, or foam cells, take-up and process lipoprotein particles deposited in arteries, and store much of the cholesterol carried by these particles in their cy
Externí odkaz:
https://doaj.org/article/f67423439c264e01924f5f014d41a14b
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 4 (2016)
BackgroundFoam cells are central to two major pathogenic processes in atherogenesis: cholesterol buildup in arteries and inflammation. The main underlying cause of cholesterol deposition in arteries is hypercholesterolemia. This study aimed to assess
Externí odkaz:
https://doaj.org/article/4fc06332156d4055a0d5d2a25ed6623c
Autor:
Ryan Hogan, Mousumi Moulik, Vijay Yechoor, Barbara Plitnick, Jeongkyung Lee, Young-Hwa Goo, Kiran Jahangir, Antoni Paul, Mariana G. Figueiro
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Despite compelling epidemiological evidence that circadian disruption inherent to long‐term shift work enhances atherosclerosis progression and vascular events, the underlying mechanisms remain poorly understood. A challenge to the use o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10d0b3d61ff6034949b2bf86b66331e
https://doi.org/10.1161/jaha.120.018151
https://doi.org/10.1161/jaha.120.018151
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33063 (2012)
Interventions on macrophages/foam cells to redirect intracellular cholesterol towards efflux pathways could become a very valuable addition to our therapeutic arsenal against atherosclerosis. However, certain manipulations of the cholesteryl ester cy
Externí odkaz:
https://doaj.org/article/fc05797f2e2e4e8a90d338ff38ca81cc
Autor:
Barry M. Trost, Antoni Paul, Huy Quoc Nguyen, Jan E. Carette, Young-Hwa Goo, Craig Stivala, Ramin Dubey, Rajat Rohatgi
Publikováno v:
Nature chemical biology
Genetic screens in cultured human cells represent a powerful unbiased strategy to identify cellular pathways that determine drug efficacy, providing critical information for clinical development. We used insertional mutagenesis-based screens in haplo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2e1cf02124769574f7312997f7bd4f
https://pubmed.ncbi.nlm.nih.gov/31932722
https://pubmed.ncbi.nlm.nih.gov/31932722