Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Young Ho Suh"'
Autor:
Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-21 (2023)
Abstract Background There are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggreg
Externí odkaz:
https://doaj.org/article/63f416f66800494bb59e84f43141648f
Autor:
Ly Thi Huong Luu Le, Jeeyoung Lee, Dongjoon Im, Sunha Park, Kyoung‐Doo Hwang, Jung Hoon Lee, Yanxialei Jiang, Yong‐Seok Lee, Young Ho Suh, Hugh I. Kim, Min Jae Lee
Publikováno v:
Advanced Science, Vol 10, Iss 29, Pp n/a-n/a (2023)
Abstract In tauopathy conditions, such as Alzheimer's disease (AD), highly soluble and natively unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this process remain unclear. In the brains of AD patients, only a
Externí odkaz:
https://doaj.org/article/32f04ad8db1a47e1a7a3fc20a611b8b0
Publikováno v:
Animal Cells and Systems, Vol 26, Iss 6, Pp 380-387 (2022)
ABSTRACTAn active actin dynamic is a crucial feature of brain microglia. Here we report that LRRK2, a primary familial Parkinson’s disease-associated gene, negatively regulates microglia’s actin dynamics. LRRK2 depolymerized filamentous actin (F-
Externí odkaz:
https://doaj.org/article/8141f10e750f4c7197cacb75f9e61cdb
Autor:
Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/0f49e7ee9cb9412588f7f04d9182eeec
Publikováno v:
eLife, Vol 8 (2019)
The metabotropic glutamate receptor 7 (mGlu7) is a class C G protein-coupled receptor that modulates excitatory neurotransmitter release at the presynaptic active zone. Although post-translational modification of cellular proteins with ubiquitin is a
Externí odkaz:
https://doaj.org/article/d2591a502685468c9a93b7d3e3816299
Autor:
Kristyna Skrenkova, Sanghyeon Lee, Katarina Lichnerova, Martina Kaniakova, Hana Hansikova, Martin Zapotocky, Young Ho Suh, Martin Horak
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of Glu
Externí odkaz:
https://doaj.org/article/f06ed3023adf447b9d729b86bc265605
Autor:
Jong-hyeon Kim, Dong-joo Choi, Hey-kyeong Jeong, Jun Kim, Dae Won Kim, Soo Young Choi, Sang-Myun Park, Young Ho Suh, Ilo Jou, Eun-Hye Joe
Publikováno v:
Neurobiology of Disease, Vol 60, Iss , Pp 1-10 (2013)
Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder caused by the death of dopaminergic neurons in the substantia nigra. Importantly, altered astrocyte and microglial functions could contribute to neuronal death in PD. In
Externí odkaz:
https://doaj.org/article/66bf65230cea418984cf35f9329ac3c6
Autor:
Sangwook Park, Seulki Han, Insup Choi, Beomsue Kim, Seung Pyo Park, Eun-Hye Joe, Young Ho Suh
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163029 (2016)
The deposit of polyubiquitinated aggregates has been implicated in the pathophysiology of Parkinson's disease (PD), and growing evidence indicates that selective autophagy plays a critical role in the clearance of ubiquitin-positive protein aggregate
Externí odkaz:
https://doaj.org/article/ec78bc6f7b0b4b6cbacde1165de4defe
Publikováno v:
International Journal of Networked and Distributed Computing (IJNDC), Vol 3, Iss 4 (2015)
This paper proposes an efficient handover scheme considering the asymmetric characteristics of macro and pico cells in LTE-A HetNet. The proposed scheme detects a suitable target eNB for handover using a multi-criteria decision making algorithm and t
Externí odkaz:
https://doaj.org/article/a86647e38b09405c9ece0e64a181d6ba
Autor:
Young Ho Suh, Aki Yoshimoto-Furusawa, Karis A Weih, Lino Tessarollo, Katherine W Roche, Susan Mackem, Paul A Roche
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18444 (2011)
SNARE-mediated membrane fusion is a pivotal event for a wide-variety of biological processes. SNAP-25, a neuron-specific SNARE protein, has been well-characterized and mouse embryos lacking Snap25 are viable. However, the phenotype of mice lacking SN
Externí odkaz:
https://doaj.org/article/56e16382f6a64aff903d79046d179b26