Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia

Autor: Joana Pereira-Vieira, Daniela D. Weber, Sâmia Silva, Catarina Barbosa-Matos, Sara Granja, Rui Manuel Reis, Odília Queirós, Young H. Ko, Barbara Kofler, Margarida Casal, Fátima Baltazar

Publikováno v: Pharmaceutics, Vol 16, Iss 4, p 442 (2024)

Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study,

Externí odkaz: https://doaj.org/article/978b0580ff9f484ba50936c5618b828f

Genomic profiling for clinical decision making in lymphoid neoplasms

Autor: Laurence de Leval, Ash A. Alizadeh, P. Leif Bergsagel, Elias Campo, Andrew Davies, Ahmet Dogan, Jude Fitzgibbon, Steven M. Horwitz, Ari M. Melnick, William G. Morice, Ryan D. Morin, Bertrand Nadel, Stefano A. Pileri, Richard Rosenquist, Davide Rossi, Itziar Salaverria, Christian Steidl, Steven P. Treon, Andrew D. Zelenetz, Ranjana H. Advani, Carl E. Allen, Stephen M. Ansell, Wing C. Chan, James R. Cook, Lucy B. Cook, Francesco d’Amore, Stefan Dirnhofer, Martin Dreyling, Kieron Dunleavy, Andrew L. Feldman, Falko Fend, Philippe Gaulard, Paolo Ghia, John G. Gribben, Olivier Hermine, Daniel J. Hodson, Eric D. Hsi, Giorgio Inghirami, Elaine S. Jaffe, Kennosuke Karube, Keisuke Kataoka, Wolfram Klapper, Won Seog Kim, Rebecca L. King, Young H. Ko, Ann S. LaCasce, Georg Lenz, José I. Martin-Subero, Miguel A. Piris, Stefania Pittaluga, Laura Pasqualucci, Leticia Quintanilla-Martinez, Scott J. Rodig, Andreas Rosenwald, Gilles A. Salles, Jesus San-Miguel, Kerry J. Savage, Laurie H. Sehn, Gianpietro Semenzato, Louis M. Staudt, Steven H. Swerdlow, Constantine S. Tam, Judith Trotman, Julie M. Vose, Oliver Weigert, Wyndham H. Wilson, Jane N. Winter, Catherine J. Wu, Pier L. Zinzani, Emanuele Zucca, Adam Bagg, David W. Scott

Publikováno v: de Leval, L, Alizadeh, A A, Bergsagel, P L, Campo, E, Davies, A, Dogan, A, Fitzgibbon, J, Horwitz, S M, Melnick, A M, Morice, W G, Morin, R D, Nadel, B, Pileri, S A, Rosenquist, R, Rossi, D, Salaverria, I, Steidl, C, Treon, S P, Zelenetz, A D, Advani, R H, Allen, C E, Ansell, S M, Chan, W C, Cook, J R, Cook, L B, d'Amore, F, Dirnhofer, S, Dreyling, M, Dunleavy, K, Feldman, A L, Fend, F, Gaulard, P, Ghia, P, Gribben, J G, Hermine, O, Hodson, D J, Hsi, E D, Inghirami, G, Jaffe, E S, Karube, K, Kataoka, K, Klapper, W, Kim, W S, King, R L, Ko, Y H, LaCasce, A S, Lenz, G, Martin-Subero, J I, Piris, M A, Pittaluga, S, Pasqualucci, L, Quintanilla-Martinez, L, Rodig, S J, Rosenwald, A, Salles, G A, San-Miguel, J, Savage, K J, Sehn, L H, Semenzato, G, Staudt, L M, Swerdlow, S H, Tam, C S, Trotman, J, Vose, J M, Weigert, O, Wilson, W H, Winter, J N, Wu, C J, Zinzani, P L, Zucca, E, Bagg, A & Scott, D W 2022, ' Genomic profiling for clinical decision making in lymphoid neoplasms ', Blood, vol. 140, no. 21, pp. 2193-2227 . https://doi.org/10.1182/blood.2022015854

With the introduction of large-scale molecular profiling methods and high-throughput sequencing technologies, the genomic features of most lymphoid neoplasms have been characterized at an unprecedented scale. Although the principles for the classific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ba9d0f3ff13bffb02474c319326f5b
https://pubmed.ncbi.nlm.nih.gov/36001803

Abstract 1094: 3-Bromopyruvate reduces pancreatic tumor growth by damaging mitochondria and inhibiting glucose metabolism in both cell culture and mouse model

Autor: Sanjit Roy, Tijana Dukic, Binny Bhandary, Jason Molitoris, Young H Ko, Hem D Shukla

Publikováno v: Cancer Research. 83:1094-1094

Pancreatic cancer (PC) is the deadly cancer in both men and women, with a one-year relative survival rate of 20%, and a five-year relative survival rate of only 8%. Pancreatic cancer is characterized by dense fibrotic stroma that constitutes up to 90

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c46f2f7d0c6bb0f801ecbaa07475fc8
https://doi.org/10.1158/1538-7445.am2023-1094

Dysregulated metabolism contributes to oncogenesis

Autor: Matthew D. Hirschey, Ralph J. DeBerardinis, Anna Mae E. Diehl, Janice E. Drew, Christian Frezza, Michelle F. Green, Lee W. Jones, Young H. Ko, Anne Le, Michael A. Lea, Jason W. Locasale, Valter D. Longo, Costas A. Lyssiotis, Eoin McDonnell, Mahya Mehrmohamadi, Gregory Michelotti, Vinayak Muralidhar, Michael P. Murphy, Peter L. Pedersen, Brad Poore, Lizzia Raffaghello, Jeffrey C. Rathmell, Sharanya Sivanand, Matthew G. Vander Heiden, Kathryn E. Wellen

Publikováno v: Elsevier

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain growth, cancer cells undergo a complex metabolic rearrangement characterized by changes in metabolic pathways involved in energy production and biosynthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e43875a127c7fad5394756014e0dc23

Investigation on the Sound Absorption and Transmission for Aluminum Foam and its Composite

Autor: Jae Seol Lee, Hyoung Mo Kim, Jun-Hyung Kim, Jae Ik Cho, Young H. Ko, Chang Seog Kang, Ik Hyun Oh, Hyeon Taek Son

Publikováno v: Solid State Phenomena. :1825-1828

Although glass wool and polyurethane foam are the most widely used sound-absorber and insulating materials, there are some critical problems related to the environmental issues. In this reason, there is a lot of attention on the aluminum foam as a so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00260a74532c96c37cade9935c328b74
https://doi.org/10.4028/www.scientific.net/ssp.124-126.1825