Výsledky vyhledávání - "Young Gil Ahn"

Akademický článek

Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors

Autor: Dong Jin Hong, Seung Hyun Jung, Jisook Kim, Danbee Jung, Young Gil Ahn, Kwee Hyun Suh, Kyung Hoon Min

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 227-234 (2020)

A novel series of thieno[3,2-d]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) were assessed. cis-Isomer 17a showed potent and selective inhibitory activity against DGAT-1 in SF9

Externí odkaz: https://doaj.org/article/ada32c039eff4462af7a5b7bd0b18055

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Akademický článek

Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice.

Autor: Sang-Hyun Lee, YoungSoo Kim, Hye Yun Kim, Young Hoon Kim, Maeng Sup Kim, Jae Yang Kong, Mun-Han Lee, Dong Jin Kim, Young Gil Ahn

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95733 (2014)

Alzheimer's disease is an irreversible neurodegenerative disorder that is characterized by the abnormal aggregation of amyloid-β into neurotoxic oligomers and plaques. Although many disease-modifying molecules are currently in Alzheimer clinical tri

Externí odkaz: https://doaj.org/article/71619b57b0bf44738486e164ad55a88f

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Abstract 1625: A novel SOS1 inhibitor, HM99462 demonstrates antitumor activity against KRAS-mutant cancers

Autor: Seung Hyun Jung, Jaeyul Choi, Wongi Park, Jooyun Byun, Semi Lim, Youngjoo Lee, Yu-Yon Kim, Hyunjin Park, So-Ye Jeon, Taehun Song, Kyungjin Choi, Tae-yeon Kong, Heecheol Kim, Wook Jang, EunYoung Lee, Minhwa Kim, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh

Publikováno v: Cancer Research. 83:1625-1625

KRAS is a well-known oncogene with the highest mutation rate among various cancers. KRAS cycles between GDP-loaded ‘off’ and GTP-loaded ‘on’ states induce downstream signal transduction to promote cell proliferation and survival. Interconvers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3bd2a9486353e20d0113f2ef2eae135
https://doi.org/10.1158/1538-7445.am2023-1625

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Abstract 1614: Antitumor activity of novel and potent YAP/TAZ-TEAD inhibitorstargeting the Hippo pathway in solid tumors

Autor: Jisook Kim, Seung Hyun Jung, Seon Yeong Han, Jihee Yoon, Minjeong Kim, Jooyun Byun, Heesun Moon, Eunyoung Lee, Yu-Yon Kim, Hyunjin Park, So-Ye Jeon, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh

Publikováno v: Cancer Research. 83:1614-1614

The Hippo pathway is evolutionarily conserved and known to regulate diverse cellular processes, including cell survival, proliferation, differentiation, migration, and organ size. The key regulator of Hippo pathway is transcriptional enhanced associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dc9907eb58473b45261e2819b9d3a48
https://doi.org/10.1158/1538-7445.am2023-1614

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Abstract 6267: A novel and potent EZH1/2 dual inhibitor, HM97662 demonstrates antitumor activity in T-cell lymphoma

Autor: Jooyun Byun, Seung Hyun Jung, Yu-Yon Kim, Miyoung Lee, Gunwoo Lee, Heesun Moon, Eun Young Lee, Junghwa Park, Seon Yeong Han, Young Gil Ahn, Young Hoon Kim, Kwee Hyun Suh

Publikováno v: Cancer Research. 83:6267-6267

Chromatin remodeling is a crucial process for transcriptional regulation, of which dysregulation is often observed in various human cancers. The enhancer of zeste homology 2 (EZH2) and its homolog EZH1 are catalytic subunits of polycomb repressive co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad364aae517a4159023e4cc81d84cefe
https://doi.org/10.1158/1538-7445.am2023-6267

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Synergistic Effects of BTK Inhibitor HM71224 and Methotrexate in a Collagen-induced Arthritis Rat Model

Autor: Yu-Yon Kim, Kyung Jin Choi, Young Gil Ahn, Sun Young Jang, Young Hoon Kim, Kwee Hyun Suh, Hyung Sik Kim

Publikováno v: In Vivo

Background/Aim: Using a rat model of collagen-induced arthritis (CIA), we evaluated the therapeutic effects of HM71224 (BTKi), as well as the drug-drug interactions in combined therapy with methotrexate (MTX) based on both drugs’ pharmacological ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb624f42c59ffffb38cda6050d59b36b
https://doi.org/10.21873/invivo.12619

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Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells

Publikováno v: Investigational New Drugs. 38:1696-1706

Inhibitor of apoptosis proteins (IAPs) are overexpressed in the majority of cancers and prevent apoptosis by inhibiting caspases. IAPs have therefore attracted considerable attention as potential targets for anticancer therapy. Here, we demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c09df164e5ed9bd2d42f0dc4697713
https://doi.org/10.1007/s10637-020-00956-9

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