Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Young Geun Mok"'
Autor:
Jaesuk Lee, Kayeong Lim, Annie Kim, Young Geun Mok, Eugene Chung, Sung-Ik Cho, Ji Min Lee, Jin-Soo Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Cas9 nickases (nCas9s) produce nicks or single-strand breaks in the DNA. Here the authors analyse the on- and off-target nicks generated by these nickases, and show that nCas9 (H840A) but not nCas9 (D10A) can cleave both strands and produce unwanted
Externí odkaz:
https://doaj.org/article/d4e6a4c2bb8349c89d41ddb7631ab4af
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Monomeric DdCBEs (mDdCBEs), enabling mitochondrial DNA editing with high efficiencies of up to 50%, when transiently expressed in cultured human cells and nearly homoplasmic C-to-T editing via AAV.
Externí odkaz:
https://doaj.org/article/217dabfa7f04465aa29214433432d07a
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract DNA methylation is a prominent epigenetic modification in plants and animals regulated by similar mechanisms but the process of DNA demethylation is profoundly different. Unlike vertebrates that require a series of enzymatic conversions of 5
Externí odkaz:
https://doaj.org/article/9b9a078def3d452bbdaac6589bfe3a7a
Publikováno v:
Nature Plants. 8:1378-1384
Chloroplast DNA (cpDNA) encodes up to 315 (typically, 120–130) genes1, including those for essential components in photosystems I and II and the large subunit of RuBisCo, which catalyses CO2 fixation in plants. Targeted mutagenesis in cpDNA will be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b0acb5ddf69a9658badc07e610777c
https://doi.org/10.1038/s41477-022-01279-8
https://doi.org/10.1038/s41477-022-01279-8
Autor:
Jaesuk Lee, Kayeong Lim, Annie Kim, Young Geun Mok, Eugene Chung, Sung-Ik Cho, Ji Min Lee, Jin-Soo Kim
Unlike CRISPR-Cas9 nucleases, which yield DNA double-strand breaks (DSBs), Cas9 nickases (nCas9s), which are created by replacing key catalytic amino-acid residues in one of the two nuclease domains of S. pyogenesis Cas9 (SpCas9), produce nicks or si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d074bb2c224754fe6dbb1b86508a0a41
https://doi.org/10.21203/rs.3.rs-2236723/v1
https://doi.org/10.21203/rs.3.rs-2236723/v1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1072, p 1072 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences
Volume 22
Issue 3
In higher eukaryotes DNA methylation is a prominent epigenetic mark important for chromatin structure and gene expression. Thus, profiling DNA methylation is important for predicting gene expressions associated with specific traits or diseases. DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b390faf80ce0e638e7ee80c97a190e73
https://www.mdpi.com/1422-0067/22/3/1072
https://www.mdpi.com/1422-0067/22/3/1072
Autor:
Sung-Ik Cho, Seonghyun Lee, Young Geun Mok, Kayeong Lim, Jaesuk Lee, Ji Min Lee, Eugene Chung, Jin-Soo Kim
Publikováno v:
Cell. 185:1764-1776.e12
Mitochondrial DNA (mtDNA) editing paves the way for disease modeling of mitochondrial genetic disorders in cell lines and animals and also for the treatment of these diseases in the future. Bacterial cytidine deaminase DddA-derived cytosine base edit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7147f9102db0df0fdcb3c3b9edb139f6
https://doi.org/10.1016/j.cell.2022.03.039
https://doi.org/10.1016/j.cell.2022.03.039
Publikováno v:
SCIENTIFIC REPORTS(7)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
DNA methylation is a prominent epigenetic modification in plants and animals regulated by similar mechanisms but the process of DNA demethylation is profoundly different. Unlike vertebrates that require a series of enzymatic conversions of 5-methylcy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad66c709c8c2a3b4080459e39c5ccc6
http://open-repository.kisti.re.kr/cube/handle/open_repository/476890.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/476890.do
Autor:
Jaekyung Shim, Dong Gwan Kim, Young Geun Mok, Chang Eun Lee, Seong-Ki Kim, Jong Soon Choi, Barry P. Rosen, Joohyun Lee, Young Jin Kim, Hyoung Sun Shin, Byoung-Doo Lee, Yuling Meng, Seongbin Hwang, June Seung Lee
Publikováno v:
FEBS Letters. 582:916-924
We cloned a plant gene, Ntcyc07, conferring arsenite tolerance by expressing a tobacco expression library in WT yeast (Y800). Expression of Ntcyc07 increased the tolerance to As(III) and decreased its accumulation, suggesting that the enhanced As(III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e4bae55d0c70bd8efa739d6dbdefda
https://doi.org/10.1016/j.febslet.2008.02.030
https://doi.org/10.1016/j.febslet.2008.02.030
Publikováno v:
NUCLEIC ACIDS RESEARCH(42): 18
Nucleic Acids Research
Nucleic Acids Research
DNA methylation is a primary epigenetic modification regulating gene expression and chromatin structure in many eukaryotes. Plants have a unique DNA demethylation system in that 5-methylcytosine (5mC) is directly removed by DNA demethylases, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9043698a2d0f15b58c53b291b5ac527f
http://open-repository.kisti.re.kr/cube/handle/open_repository/474975.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/474975.do