Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Young Eum Hyun"'
Autor:
Young Eum Hyun, Seungchan An, Minjae Kim, In Guk Park, Sanghee Yoon, Hafiz Muhammad Ahmad Javaid, Thi Ngoc Lan Vu, Gyudong Kim, Hongseok Choi, Hyuk Woo Lee, Minsoo Noh, Joo Young Huh, Sun Choi, Hong-Rae Kim, Lak Shin Jeong
Publikováno v:
Journal of Medicinal Chemistry. 66:4961-4978
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe91b95695d9dffb604b4ac6187c6d1a
https://doi.org/10.1021/acs.jmedchem.2c02071
https://doi.org/10.1021/acs.jmedchem.2c02071
Autor:
Young Eum Hyun, Dnyandev B. Jarhad, Minjae Kim, Ayeon Yang, Gyudong Kim, Hong-Rae Kim, Lak Shin Jeong
Publikováno v:
Organic Letters. 24:9281-9284
The conformation of the central five-membered ring of a nucleoside plays an important role in enzyme recognition. Bicyclo[3.1.0]hexane, also known as the methanocarba (MC), serves as a template that can mimic the locked forms of the two distinctive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2761d05a17ebf554f03853969b12ff8d
https://doi.org/10.1021/acs.orglett.2c03853
https://doi.org/10.1021/acs.orglett.2c03853
Autor:
Mai Nguyen, Seungchan An, Yen Nguyen, Young Eum Hyun, Hongseok Choi, Linh Pham, Jung-Ae Kim, Minsoo Noh, Gyudong Kim, Lak Shin Jeong
Publikováno v:
ACS medicinal chemistry letters. 13(7)
On the basis of the previously reported polypharmacological profile of truncated d-1'-homologated adenosine derivatives [J. Med. Chem.2020, 63, 16012], the l-nucleoside analogues were synthesized using computer-aided design and evaluated for biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8ea384761a97a07bf1daa2e054d8a7
https://pubmed.ncbi.nlm.nih.gov/35859875
https://pubmed.ncbi.nlm.nih.gov/35859875
Autor:
Anna Shiriaeva, Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B. Jarhad, Gibae Kim, Jinha Yu, Young Eum Hyun, Woomi Kim, Zhan-Guo Gao, Kenneth A. Jacobson, Gye Won Han, Raymond C. Stevens, Lak Shin Jeong, Sun Choi, Vadim Cherezov
Publikováno v:
Journal of Medicinal Chemistry. 65:11648-11657
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b6f79bf66b85c0a0487a8a2f2f7e352
https://doi.org/10.1021/acs.jmedchem.2c00462
https://doi.org/10.1021/acs.jmedchem.2c00462
Publikováno v:
The Journal of Organic Chemistry. 86:9828-9837
To determine which sugar conformation is favorable in binding to peroxisome proliferator-activated receptors, the conformationally locked south (S) and north (N) analogues were asymmetrically synthesized using a bicyclo[3.1.0]hexane template. The (S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdf7ed1a1d5f2e0c237933b483bfccb
https://doi.org/10.1021/acs.joc.1c00705
https://doi.org/10.1021/acs.joc.1c00705
Autor:
Anna, Shiriaeva, Daejin, Park, Gyudong, Kim, Yoonji, Lee, Xiyan, Hou, Dnyandev B, Jarhad, Gibae, Kim, Jinha, Yu, Young Eum, Hyun, Woomi, Kim, Zhan-Guo, Gao, Kenneth A, Jacobson, Gye Won, Han, Raymond C, Stevens, Lak Shin, Jeong, Sun, Choi, Vadim, Cherezov
Publikováno v:
Journal of medicinal chemistry. 65(17)
Modulators of the G protein-coupled A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d26e07dd4bffc072cb08435af2bc722
https://pubmed.ncbi.nlm.nih.gov/35977382
https://pubmed.ncbi.nlm.nih.gov/35977382
Publikováno v:
The Journal of organic chemistry. 86(14)
To determine which sugar conformation is favorable in binding to peroxisome proliferator-activated receptors, the conformationally locked south (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::646097d06d1ddc3dee443c4be3b71bb1
https://pubmed.ncbi.nlm.nih.gov/34184528
https://pubmed.ncbi.nlm.nih.gov/34184528
Autor:
Pramod K. Sahu, Kisu Sung, Dnyandev B. Jarhad, Lak Shin Jeong, Hong-Rae Kim, Dayoung An, Jinha Yu, Young Eum Hyun
Publikováno v:
Asian Journal of Organic Chemistry. 8:1641-1647
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6240b15151ac3e760c564afc7dec7db8
https://doi.org/10.1002/ajoc.201900350
https://doi.org/10.1002/ajoc.201900350
Autor:
Young Eum Hyun, Hong-Rae Kim, Min Hwan Jang, Young Sup Shin, Ji-seong Yoon, Gyudong Kim, Lak Shin Jeong, Dnyandev B. Jarhad
Publikováno v:
Organic Chemistry Frontiers. 6:959-966
Neplanocin A analogs have attracted attention in the fields of biological and medicinal chemistry due to their potent and broad-spectrum antiviral and antitumor activities. To further explore their potential as therapeutic agents, an alternative and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::413d38c00d5d4c5744edf7a6150681f6
https://doi.org/10.1039/c9qo00099b
https://doi.org/10.1039/c9qo00099b
Publikováno v:
Organic Chemistry Frontiers. 6:2480-2487
An efficient synthesis of MLN4924, a small molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trial as an anticancer agent, has been accomplished via regioselective α-alkoxy removal by Al(Hg) and stereoselective reduction based on the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d187bc0df974d52f470bb1b8913f81
https://doi.org/10.1039/c9qo00507b
https://doi.org/10.1039/c9qo00507b