Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Young Dong Yoo"'
Autor:
Hyunjoo Cha-Molstad, Ji Eun Yu, Zhiwei Feng, Su Hyun Lee, Jung Gi Kim, Peng Yang, Bitnara Han, Ki Woon Sung, Young Dong Yoo, Joonsung Hwang, Terry McGuire, Sang Mi Shim, Hyun Dong Song, Srinivasrao Ganipisetti, Nuozhou Wang, Jun Min Jang, Min Jae Lee, Seung Jun Kim, Kyung Ho Lee, Jin Tae Hong, Aaron Ciechanover, Inhee Mook-Jung, Kwang Pyo Kim, Xiang-Qun Xie, Yong Tae Kwon, Bo Yeon Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin
Externí odkaz:
https://doaj.org/article/a427518b7ba242ffb3606852a4c4bba9
Autor:
Jee Young An, Euna Kim, Adriana Zakrzewska, Young Dong Yoo, Jun Min Jang, Dong Hoon Han, Min Jae Lee, Jai Wha Seo, Yong Jun Lee, Tae-You Kim, Dirk G de Rooij, Bo Yeon Kim, Yong Tae Kwon
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37414 (2012)
The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons. The RING E3 ligases UB
Externí odkaz:
https://doaj.org/article/d39895ed2bc647f1800886811d1a09d8
Autor:
Ha Hee Jin, Aeran Jung, Yoonji Lee, Timothy E. Esch, Nayeon Do, Jin Ju Jeong, Jeewoo Lee, Jisoo Baek, Peter M. Blumberg, Sunhye Hong, Dongxu Zuo, Shivaji A. Thorat, Jihyae Ann, Noe A. Turcios, Larry V. Pearce, Young Dong Yoo, Songyeon Ahn, Sun Choi
Publikováno v:
Journal of medicinal chemistry. 64(1)
Among a series of benzopyridone-based scaffolds investigated as human transient receptor potential vanilloid 1 (TRPV1) ligands, two isomeric benzopyridone scaffolds demonstrated a consistent and distinctive functional profile in which 2-oxo-1,2-dihyd
Autor:
Sun Ok Kwon, Jeewoo Lee, Hannelore Stockhausen, Bernhard Lesch, Jin Mi Kang, Jihyae Ann, Gregor Bahrenberg, Young Dong Yoo, Robert Frank-Foltyn, Thomas Christoph, Peter M. Blumberg, Hee-Jin Ha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127548
A series of 1-indazol-3-(1-phenylpyrazol-5-yl)methyl ureas were investigated as hTRPV1 antagonists. The structure–activity relationship study was conducted systematically for both the indazole A-region and the 3-trifluoromethyl/t-butyl pyrazole C-r
Autor:
Myeong Seup Kim, Songyeon Ahn, Thomas Christoph, Young Dong Yoo, Yong Soo Kim, Jeewoo Lee, Gregor Bahrenberg, Peter M. Blumberg, Jihyae Ann, Robert Frank-Foltyn, Hee-Jin Ha, Young Ho Kim, Hannelore Stockhausen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126838
A series of indane-type acetamide and propanamide analogues were investigated as TRPV1 antagonists. The analysis of structure–activity relationship indicated that indane A-region analogues exhibited better antagonism than did the corresponding 2,3-
Autor:
Hobin Lee, Young Ho Kim, Timothy E. Esch, Kwang-Hyun Hur, Songyeon Ahn, Nancy E. Lewin, Jihyae Ann, Young Dong Yoo, Larry V. Pearce, Choon-Gon Jang, Jeewoo Lee, Peter M. Blumberg, Hee-Jin Ha, Ji-Young Hwang
Publikováno v:
Eur J Med Chem
In order to discover a novel type of analgesic, we investigated dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single target
Autor:
Bo Yeon Kim, Kyung Ho Lee, Hyunjoo Cha-Molstad, Sangku Lee, Sung Tae Kim, Young Dong Yoo, Daehwan Kim, Eung Ho Choi, Hyun Jung Kim, Yong Tae Kwon, Hee Gu Lee, Mi Ja Ahn, Jin Tae Hong, Jong Seog Ahn, Goeun Han, Soo Chan Kim, Nak Kyun Soung, In Ja Ryoo, Min Jae Lee, Joonsung Hwang
Publikováno v:
Experimental dermatology. 27(11)
Atopic dermatitis (AD) is a chronic inflammatory skin disease whose prevalence is increasing worldwide. Filaggrin (FLG) is essential for the development of the skin barrier, and its genetic mutations are major predisposing factors for AD. In this stu
Autor:
Sung Tae Kim, Hyunjoo Cha-Molstad, Young Dong Yoo, Yong Tae Kwon, Bo Yeon Kim, Aaron Ciechanover, Yoon Jee Lee, Su Hyun Lee, Jung Gi Kim, Ji Eun Yu, Dae Hee Lee, Joonsung Hwang, Ki Sa Sung
Publikováno v:
Autophagy. 12:426-428
The N-end rule pathway is a proteolytic system, in which single N-terminal residues act as a determinant of a class of degrons, called N-degrons. In the ubiquitin (Ub)-proteasome system, specific recognition components, called N-recognins, recognize
Autor:
Kyung Ho Lee, Min Jae Lee, Ki Woon Sung, Hyunjoo Cha-Molstad, Nuozhou Wang, Aaron Ciechanover, Yong Tae Kwon, Sang Mi Shim, Seung Jun Kim, Inhee Mook-Jung, Jun Min Jang, Terry McGuire, Kwang Pyo Kim, Bitnara Han, Xiang-Qun Xie, Peng Yang, Young Dong Yoo, Bo Yeon Kim, Joonsung Hwang, Ganipisetti Srinivasrao, Jin Tae Hong, Jung Gi Kim, Ji Eun Yu, Hyun Dong Song, Zhiwei Feng, Su Hyun Lee
Publikováno v:
NATURE COMMUNICATIONS(8)
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents. Here, we show that the N-end rule pathway modulates macroautophagy. In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c1df87add4855d6e4ed5c4785cebed
http://open-repository.kisti.re.kr/cube/handle/open_repository/482901.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/482901.do
Autor:
Joonsung Hwang, Sang Cheul Oh, Shin Hyuk Kang, Ki Sa Sung, Dae Hee Lee, Su Ran Mun, Hyungsin Kim, Young Dong Yoo, Changhoon Ji, Seong Hye Park, Kyung Jae Park, Deric M. Park, Yong J. Lee, Seung-Ki Kim, Kim Bo Yeon, Seung Ah Choi, Aaron Ciechanover, Yong Tae Kwon, Hyunjoo Cha-Molstad
Although proteasome inhibitors (PIs) are used as anticancer drugs to treat various cancers, their relative therapeutic efficacy on stem cells vs. bulk cancers remains unknown. Here, we show that stem cells derived from gliomas, GSCs, are up to 1,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034fb9c71b3cc892afa2853f84d3f13c
https://europepmc.org/articles/PMC5210095/
https://europepmc.org/articles/PMC5210095/