Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Young Don, Hong"'
Publikováno v:
Nuclear Medicine and Biology. 40:424-429
Introduction For the development of safe and effective protein-based radiolabeled complexes such as radioimmunotherapy (RIT), the selection of the radionuclides and the chelating agents used for the radiolabeling of tumor-targeting molecules is a cri
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 27:464-472
In this study, a novel α-melanocyte stimulating hormone (α-MSH) analogue 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) coupled [Gly3-cyclized(Dap4, d-Phe7, Asp10)-Arg11]α-MSH3–13 (DOTA-GMSH) for melanocortin-1 receptor (MC-1R)
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:10-17
Integrin ανβ3 is a receptor and is highly expressed on activated and proliferating endothelial cells during the growth and metastasis of solid tumors but not on resting endothelial cells and normal organs. Because RGD peptide binds to integrin α
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 292:203-209
The organometallic precursor of fac-[99mTc(CO)3(H2O)3]+ has attracted much attention because of the robustness and small size of Tc(I)-tricarbonyl complexes compared to Tc(V) complexes and the good labeling affinity with a variety of donor atoms. Amo
Publikováno v:
Applied Radiation and Isotopes. 67:1366-1369
In this study, we carried out a radioimmunoconjugation using 177Lu with anti-CD105 (endoglin) monoclonal antibody for an angiogenesis targeting. CD105 has been shown to be a more useful marker to identify proliferating endothelium involved in tumor a
Publikováno v:
Bulletin of the Korean Chemical Society. 30:1107-1112
The aim of this study is to develop and synthesize 5-HT 1A receptor imaging agents with WAY-100635 moiety and 99m Tc(CO) 3 core. WAY-100635 is commonly known as 5-HT 1A antagonist and its labeled compound ([ 11 C] WAY-100635) has been used as effecti
Publikováno v:
Bulletin of the Korean Chemical Society. 27:1689-1692
Publikováno v:
Bulletin of the Korean Chemical Society. 27:1194-1198
For the purpose of developing more effective chelating agents, we have synthesized a diethylene triamine pentaacetic acid(DTPA) analogue by using an amino acid. S-(N-Boc-aminophenyl)-Cys(t-Bu4-DTPA) methylester was prepared in 6 steps with total yiel
99mTc(CO)3-Labeled Histidine-Arylpiperazines as Potential Radiotracers for a Neuroreceptor Targeting
Publikováno v:
Bulletin of the Korean Chemical Society. 27:1189-1193
In order to develop radiopharmaceuticals for targeting a serotonin receptor such as 5-HT 1A , histidine-C n -arylpiperazines (AP) (C = alkyl, n = 2, 3, 4) were prepared in five steps with yields of 25%, 37% and 51%, respectively, and radiolabeled wit
Publikováno v:
Nuclear Medicine and Biology. 29:833-839
Liquid radiation sources with β emitters have advantages of accurate positioning and uniform dose distribution to the vessel walls to prevent the restenosis of coronary artery. As a liquid radiation source, 166 Ho-DTPA was prepared and evaluated its