Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Young D. Kwon"'
Autor:
Young D. Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F. Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C. Lin, Tracy Liu, Mark K. Louder, Reda Rawi, Mateo Reveiz, Andrew J. Schaub, Chen-Hsiang Shen, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe amino-acid composition of the immunoglobulin variable region has been observed to impact antibody pharmacokinetics (PK). Here, we sought to improve the PK of the broad HIV−1-neutralizing VRC01-class antibodies, VRC07-523LS and N6LS, by
Externí odkaz:
https://doaj.org/article/404c6bcba63e47658183c99f62376df3
Autor:
Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, Peter D. Kwong
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody CAP256-VRC26.25 targets the second hypervariable region (V2) at the apex of the HIV envelope (Env) trimer with extraordinary neutralization potency, although less than optimal breadth. To improve breadth, we linked the light chain of
Externí odkaz:
https://doaj.org/article/bddbe9ec6f5b4b779bcbe4b49830cab8
Publikováno v:
IEEE Access, Vol 8, Pp 197379-197406 (2020)
Computational Politics is the study of computational methods to analyze and moderate users' behaviors related to political activities such as election campaign persuasion, political affiliation, and opinion mining. With the rapid development and ease
Externí odkaz:
https://doaj.org/article/9d7a240eaa924c45b46f47792600c323
Autor:
Francesca Curreli, Young D. Kwon, Isabella Nicolau, Giancarla Burgos, Andrea Altieri, Alexander V. Kurkin, Raffaello Verardi, Peter D. Kwong, Asim K. Debnath
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15999 (2022)
As part of our effort to discover drugs that target HIV-1 entry, we report the antiviral activity and crystal structures of two novel inhibitors in a complex with a gp120 core. NBD-14204 showed similar antiviral activity against all the clinical isol
Externí odkaz:
https://doaj.org/article/980cf339d69a440f8d9635b4804074e1
Autor:
Young D. Kwon, Mangaiarkarasi Asokan, Jason Gorman, Baoshan Zhang, Qingbo Liu, Mark K. Louder, Bob C. Lin, Krisha McKee, Amarendra Pegu, Raffaello Verardi, Eun Sung Yang, VRC Production Program, Kevin Carlton, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based de
Externí odkaz:
https://doaj.org/article/fd7ff32ab1e546deaa0798bcdf196936
Autor:
Kimmo Rantalainen, Zachary T. Berndsen, Aleksandar Antanasijevic, Torben Schiffner, Xi Zhang, Wen-Hsin Lee, Jonathan L. Torres, Lei Zhang, Adriana Irimia, Jeffrey Copps, Kenneth H. Zhou, Young D. Kwon, William H. Law, Chaim A. Schramm, Raffaello Verardi, Shelly J. Krebs, Peter D. Kwong, Nicole A. Doria-Rose, Ian A. Wilson, Michael B. Zwick, John R. Yates, III, William R. Schief, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with inherent flexibility of the molecule and the membrane-embedded hydrophobic regions. Here
Externí odkaz:
https://doaj.org/article/d9f16fbf109a4f2f9110c0d89c79dd68
Autor:
Young D. Kwon, Gwo-Yu Chuang, Baoshan Zhang, Robert T. Bailer, Nicole A. Doria-Rose, Tatyana S. Gindin, Bob Lin, Mark K. Louder, Krisha McKee, Sijy O’Dell, Amarendra Pegu, Stephen D. Schmidt, Mangaiarkarasi Asokan, Xuejun Chen, Misook Choe, Ivelin S. Georgiev, Vivian Jin, Marie Pancera, Reda Rawi, Keyun Wang, Rajoshi Chaudhuri, Lisa A. Kueltzo, Slobodanka D. Manceva, John-Paul Todd, Diana G. Scorpio, Mikyung Kim, Ellis L. Reinherz, Kshitij Wagh, Bette M. Korber, Mark Connors, Lawrence Shapiro, John R. Mascola, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1798-1809 (2018)
Summary: Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, an antibody capable of near pan-HIV-1 neutralization, we engineered 10E8-surface mutants and
Externí odkaz:
https://doaj.org/article/20803a2ba97341ed985e9c54c91c448e
Autor:
Vikas Chonira, Young D. Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G. Casner, Darcy R. Harris, Adam S. Olia, Tyler Stephens, Lawrence Shapiro, Michael F. Bender, Hannah Boyd, I-Ting Teng, Yaroslav Tsybovsky, Florian Krammer, Ningyan Zhang, Michael S. Diamond, Peter D. Kwong, Zhiqiang An, Zhilei Chen
Publikováno v:
Nature Chemical Biology. 19:284-291
A particular phenomenon of interest in Retail Economics is the spillover effect of anchor stores (specific stores with a reputable brand) to non-anchor stores in terms of customer traffic. Prior works in this area rely on small and survey-based datas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862d3422a76a8a6ed10d8f785fee5273
http://arxiv.org/abs/2210.13582
http://arxiv.org/abs/2210.13582
Publikováno v:
2022 30th European Signal Processing Conference (EUSIPCO).