Zeranol Induces Deleterious Effects on the Testes and the Prostate Gland of Mature Rats

Autor: Samuel K. Kulp, Young C. Lin, F Shidaifat

Publikováno v: Endocrine Research. 38:232-241

Endocrine disrupters have been shown to affect the male and female reproductive systems and to alter potential fertility.This study was conducted to evaluate the effect of a continuous-release pellet containing 12 mg of zeranol for 30 days on the tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7a0ba923360425ddf44f50dcbe424c
https://doi.org/10.3109/07435800.2013.774410

Liposomes Containing (-)-Gossypol-Enriched Cottonseed Oil Suppress Bcl-2 and Bcl-xL Expression in Breast Cancer Cells

Autor: Robert J. Lee, Hong Li, Young C. Lin, L. James Lee, Samuel K. Kulp, Shu-Hong Lin, Pingping Xu, Weiping Ye, Youngah Cho, Saiyi Zhong, Longzhu Piao, Yicheng Mao

Publikováno v: Pharmaceutical Research. 28:3256-3264

We have demonstrated that (-)-gossypol-enriched cottonseed oil [(-)-GPCSO] can down-regulate Bcl-2 expression in MCF-7 and primary cultured human breast cancer epithelial cells (PCHBCECs). However, this agent has not been evaluated in vivo due to its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c488cdd4b61bc6f3ca7620b006377
https://doi.org/10.1007/s11095-011-0498-2

Zeranol Down-Regulates p53 Expression in Primary Cultured Human Breast Cancer Epithelial Cells through Epigenetic Modification

Autor: Jie-Yu Liu, Pingping Xu, Hong Li, Young C. Lin, Eric Feng, Robert Jen, Saiyi Zhong, Shu-Hong Lin, Weiping Ye

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 12, Iss 3, Pp 1519-1532 (2011)
International Journal of Molecular Sciences; Volume 12; Issue 3; Pages: 1519-1532

Epidemiological studies have suggested that there are many risk factors associated with breast cancer. Silencing tumor suppressor genes through epigenetic alterations play critical roles in breast cancer initiation, promotion and progression. As a gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e657161b233bbcb6178a634e70b3a52a
http://europepmc.org/articles/PMC3111616

Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer

Autor: Robert W. Brueggemeier, Charles L. Shapiro, Yasuro Sugimoto, Edgar S. Diaz-Cruz, Young C. Lin, Pui-Kai Li

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 95:129-136

Aromatase expression and enzyme activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue. Regulation of aromatase expression in human tissues is quite complex, involving alternative promoter sit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bed660c920e3db798ab3433d690c9b2
https://doi.org/10.1016/j.jsbmb.2005.04.013

Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-γ (PTPγ) mRNA expression by estrogenically active agents

Autor: Samuel K. Kulp, Yasuro Sugimoto, Jiahua Jiang, Suling Liu, Hsiang-Lin Chang, Young C. Lin

Publikováno v: Breast Cancer Research and Treatment. 71:21-35

Protein tyrosine phosphatase gamma (PTPgamma) has been implicated as a tumor suppressor gene in kidney and lung cancers. Our previous results indicate that estradiol-17beta (E2)-induced suppression of PTPgamma may play a role in mammary tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93abd4cb233d5e2d7187bf0039b10cec
https://doi.org/10.1023/a:1013343718942