Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Young C Shin"'
1
Akademický článek
Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques.
Autor: Lucas Gonzalez-Nieto, Isabelle M Castro, Georg F Bischof, Young C Shin, Michael J Ricciardi, Varian K Bailey, Christine M Dang, Nuria Pedreño-Lopez, Diogo M Magnani, Keisuke Ejima, David B Allison, Hwi Min Gil, David T Evans, Eva G Rakasz, Jeffrey D Lifson, Ronald C Desrosiers, Mauricio A Martins
Publikováno v: PLoS Pathogens, Vol 15, Iss 9, p e1008015 (2019)
A prophylactic vaccine against human immunodeficiency virus (HIV) remains a top priority in biomedical research. Given the failure of conventional immunization protocols to confer robust protection against HIV, new and unconventional approaches may b
Externí odkaz: https://doaj.org/article/7e6e831fadc24404a14cf0b3646c06d4
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2
Akademický článek
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products.
Autor: Young C Shin, Georg F Bischof, William A Lauer, Lucas Gonzalez-Nieto, Eva G Rakasz, Gregory M Hendricks, David I Watkins, Mauricio A Martins, Ronald C Desrosiers
Publikováno v: PLoS Pathogens, Vol 14, Iss 6, p e1007143 (2018)
The properties of the human immunodeficiency virus (HIV) pose serious difficulties for the development of an effective prophylactic vaccine. Here we describe the construction and characterization of recombinant (r), replication-competent forms of rhe
Externí odkaz: https://doaj.org/article/46a4ad12534a4f0b9f9e81992fde32a8
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3
Akademický článek
Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.
Autor: Mauricio A Martins, Young C Shin, Lucas Gonzalez-Nieto, Aline Domingues, Martin J Gutman, Helen S Maxwell, Iris Castro, Diogo M Magnani, Michael Ricciardi, Nuria Pedreño-Lopez, Varian Bailey, Dillon Betancourt, John D Altman, Matthias Pauthner, Dennis R Burton, Benjamin von Bredow, David T Evans, Maoli Yuan, Christopher L Parks, Keisuke Ejima, David B Allison, Eva Rakasz, Glen N Barber, Saverio Capuano, Jeffrey D Lifson, Ronald C Desrosiers, David I Watkins
Publikováno v: PLoS Pathogens, Vol 13, Iss 7, p e1006529 (2017)
The ability to control lentivirus replication may be determined, in part, by the extent to which individual viral proteins are targeted by the immune system. Consequently, defining the antigens that elicit the most protective immune responses may fac
Externí odkaz: https://doaj.org/article/7f9298477dd24bad881bb9021f08cf80
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4
Akademický článek
A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein.
Autor: Pinghui Feng, Chengyu Liang, Young C Shin, E Xiaofei, Weijun Zhang, Robyn Gravel, Ting-ting Wu, Ren Sun, Edward Usherwood, Jae U Jung
Publikováno v: PLoS Pathogens, Vol 3, Iss 12, p e174 (2007)
Upon viral infection, cells undergo apoptosis as a defense against viral replication. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic processes. Here, we report that a novel viral mitochondrial anti-apoptotic protein (vMAP) o
Externí odkaz: https://doaj.org/article/3831654c5da54609999653f58f1a31ad
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5
Vaccine protection against SIVmac239 acquisition
Autor: Eva G. Rakasz, Mauricio A. Martins, Georg F. Bischof, Lucas Gonzalez-Nieto, Young C. Shin, Ronald C. Desrosiers, Jeffrey D. Lifson, David I. Watkins, William A. Lauer
Publikováno v: Proceedings of the National Academy of Sciences. 116:1739-1744
The biological characteristics of HIV pose serious difficulties for the success of a preventive vaccine. Molecularly cloned SIVmac239 is difficult for antibodies to neutralize, and a variety of vaccine approaches have had great difficulty achieving p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc69f0c19538f936f4cb7cf2765df09
https://doi.org/10.1073/pnas.1814584116
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6
Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys
Autor: Sebastian P. Fuchs, Eva G. Rakasz, Young C. Shin, José M. Martinez-Navio, William A. Lauer, Georg F. Bischof, Ronald C. Desrosiers
Publikováno v: Gene Therapy. 24:487-492
The gamma-2 herpesvirus of rhesus monkeys, rhesus monkey rhadinovirus (RRV), persists principally in B cells of its host. We constructed recombinant strains of RRV expressing the rhesus monkey-derived anti-SIV monoclonal antibodies 4L6 and 5L7 and co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6168a7323786d9e39c8937bfa45b718
https://doi.org/10.1038/gt.2017.49
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10
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products
Autor: Mauricio A. Martins, Eva G. Rakasz, Georg F. Bischof, Lucas Gonzalez-Nieto, David I. Watkins, Young C. Shin, Gregory M. Hendricks, William A. Lauer, Ronald C. Desrosiers
Publikováno v: PLoS Pathogens, Vol 14, Iss 6, p e1007143 (2018)
PLoS Pathogens
The properties of the human immunodeficiency virus (HIV) pose serious difficulties for the development of an effective prophylactic vaccine. Here we describe the construction and characterization of recombinant (r), replication-competent forms of rhe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623c1f910d768de91cd60f7cd99c9953
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/10042
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